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HIST1H3D cDNA ORF clone, Homo sapiens (human)

Gene Symbol HIST1H3D
Entrez Gene ID 8351
Full Name histone cluster 1, H3d
Synonyms H3/b, H3FB
General protein information
Preferred Names
histone H3.1
Names
histone H3.1
histone H3/b
histone 1, H3d
H3 histone family, member B
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p22.1

Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]. lac of sum
Disorder MIM:

602811


mRNA and Protein(s)

mRNA Protein Name
NM_003530 NP_003521 histone H3.1



Homo sapiens (human) HIST1H3D NP_003521.2
Pan troglodytes (chimpanzee) LOC462506 XP_003950810.1
Macaca mulatta (Rhesus monkey) LOC698731 XP_001088393.1
Canis lupus familiaris (dog) LOC100684574 XP_005640156.1
Bos taurus (cattle) LOC525511 XP_005223856.1
Mus musculus (house mouse) Hist1h3a NP_038578.2
Rattus norvegicus (Norway rat) LOC691496 NP_001103112.1
Danio rerio (zebrafish) LOC100329422 XP_002666952.2
Drosophila melanogaster (fruit fly) His3:CG33848 NP_001027358.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100487139 XP_002944966.1

The following HIST1H3D gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HIST1H3D cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu16779
NM_003530 Homo sapiens histone cluster 1, H3d (HIST1H3D), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
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30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu16779
Clone ID Related Accession (Same CDS sequence) NM_003530
Accession Version NM_003530.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 411bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 18-AUG-2015
Organism Homo sapiens (human)
Product histone H3.1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB242999.1 and BC031333.1. On Feb 5, 2013 this sequence version replaced gi:39812261. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK316611.1, BQ051491.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
ATGGCTCGTA CCAAGCAGAC TGCTCGCAAG TCCACGGGTG GGAAAGCGCC ACGCAAGCAG 
CTGGCCACCA AGGCTGCTCG AAAGAGCGCT CCAGCCACCG GCGGCGTGAA GAAGCCCCAC
CGTTACCGGC CCGGCACGGT GGCTCTGCGC GAGATCCGCC GCTACCAGAA GTCGACCGAG
CTGCTGATTC GCAAACTGCC ATTCCAGCGT CTAGTCCGTG AGATCGCGCA GGACTTCAAG
ACTGATCTGC GTTTTCAGAG CTCGGCGGTG ATGGCGCTGC AGGAGGCCTG CGAGGCCTAC
CTGGTGGGGC TGTTTGAGGA CACCAACCTA TGCGCCATTC ACGCCAAGCG AGTGACTATC
ATGCCCAAGG ACATCCAGCT TGCTCGCCGC ATTCGTGGGG AGAGGGCGTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_003521.2
CDS455..865
Misc Feature(1)443..445(+)
Misc Feature(2)455..862(+)
Misc Feature(3)455..853(+)
Misc Feature(4)461..463(+)
Misc Feature(5)461..463(+)
Misc Feature(6)464..466(+)
Misc Feature(7)467..469(+)
Misc Feature(8)467..469(+)
Misc Feature(9)467..469(+)
Misc Feature(10)473..475(+)
Misc Feature(11)479..481(+)
Misc Feature(12)479..481(+)
Misc Feature(13)482..484(+)
Misc Feature(14)482..484(+)
Misc Feature(15)482..484(+)
Misc Feature(16)485..487(+)
Misc Feature(17)488..490(+)
Misc Feature(18)497..499(+)
Misc Feature(19)506..508(+)
Misc Feature(20)506..508(+)
Misc Feature(21)509..511(+)
Misc Feature(22)509..511(+)
Misc Feature(23)509..511(+)
Misc Feature(24)524..526(+)
Misc Feature(25)524..526(+)
Misc Feature(26)524..526(+)
Misc Feature(27)533..535(+)
Misc Feature(28)536..538(+)
Misc Feature(29)536..538(+)
Misc Feature(30)536..538(+)
Misc Feature(31)539..541(+)
Misc Feature(32)563..565(+)
Misc Feature(33)563..565(+)
Misc Feature(34)566..568(+)
Misc Feature(35)578..580(+)
Misc Feature(36)623..625(+)
Misc Feature(37)623..625(+)
Misc Feature(38)623..625(+)
Misc Feature(39)626..628(+)
Misc Feature(40)647..649(+)
Misc Feature(41)692..694(+)
Misc Feature(42)692..694(+)
Misc Feature(43)695..697(+)
Misc Feature(44)713..715(+)
Misc Feature(45)776..778(+)
Misc Feature(46)800..802(+)
Misc Feature(47)821..823(+)
Misc Feature(48)821..823(+)
Exon (1)1..435
Gene:HIST1H3D
Gene Synonym:
Exon (2)436..921
Gene:HIST1H3D
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_003530
Organism Homo sapiens (human)
Definition Homo sapiens histone cluster 1, H3d (HIST1H3D), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003530

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGGCTCGTA CCAAGCAGAC TGCTCGCAAG TCCACGGGTG GGAAAGCGCC ACGCAAGCAG 
CTGGCCACCA AGGCTGCTCG AAAGAGCGCT CCAGCCACCG GCGGCGTGAA GAAGCCCCAC
CGTTACCGGC CCGGCACGGT GGCTCTGCGC GAGATCCGCC GCTACCAGAA GTCGACCGAG
CTGCTGATTC GCAAACTGCC ATTCCAGCGT CTAGTCCGTG AGATCGCGCA GGACTTCAAG
ACTGATCTGC GTTTTCAGAG CTCGGCGGTG ATGGCGCTGC AGGAGGCCTG CGAGGCCTAC
CTGGTGGGGC TGTTTGAGGA CACCAACCTA TGCGCCATTC ACGCCAAGCG AGTGACTATC
ATGCCCAAGG ACATCCAGCT TGCTCGCCGC ATTCGTGGGG AGAGGGCGTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci
Hum. Mol. Genet. 24 (6), 1791-1800 (2015)
He M, Xu M, Zhang B, Liang J, Chen P, Lee JY, Johnson TA, Li H, Yang X, Dai J, Liang L, Gui L, Qi Q, Huang J, Li Y, Adair LS, Aung T, Cai Q, Cheng CY, Cho MC, Cho YS, Chu M, Cui B, Gao YT, Go MJ, Gu D, Gu W, Guo H, Hao Y, Hong J, Hu Z, Hu Y, Huang J, Hwang JY, Ikram MK, Jin G, Kang DH, Khor CC, Kim BJ, Kim HT, Kubo M, Lee J, Lee J, Lee NR, Li R, Li J, Liu J, Longe J, Lu W, Lu X, Miao X, Okada Y, Ong RT, Qiu G, Seielstad M, Sim X, Song H, Takeuchi F, Tanaka T, Taylor PR, Wang L, Wang W, Wang Y, Wu C, Wu Y, Xiang YB, Yamamoto K, Yang H, Liao M, Yokota M, Young T, Zhang X, Kato N, Wang QK, Zheng W, Hu FB, Lin D, Shen H, Teo YY, Mo Z, Wong TY, Lin X, Mohlke KL, Ning G, Tsunoda T, Han BG, Shu XO, Tai ES, Wu T and Qi L.


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Human tNASP promotes in vitro nucleosome assembly with histone H3.3
Biochemistry 54 (5), 1171-1179 (2015)
Kato D, Osakabe A, Tachiwana H, Tanaka H and Kurumizaka H.


book

A proteome-scale map of the human interactome network
Cell 159 (5), 1212-1226 (2014)
Rolland T, Tasan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Trigg SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barabasi AL, Iakoucheva LM, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP and Vidal M.


book

Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex
Genes Dev. 28 (9), 929-942 (2014)
Dias J, Van Nguyen N, Georgiev P, Gaub A, Brettschneider J, Cusack S, Kadlec J and Akhtar A.


book

Structure of human nucleosome containing the testis-specific histone variant TSH2B
Acta Crystallogr F Struct Biol Commun 70 (PT 4), 444-449 (2014)
Urahama T, Horikoshi N, Osakabe A, Tachiwana H and Kurumizaka H.


book

The human and mouse replication-dependent histone genes
Genomics 80 (5), 487-498 (2002)
Marzluff WF, Gongidi P, Woods KR, Jin J and Maltais LJ.


book

Regulation of chromatin structure by site-specific histone H3 methyltransferases
Nature 406 (6796), 593-599 (2000)
Rea S, Eisenhaber F, O'Carroll D, Strahl BD, Sun ZW, Schmid M, Opravil S, Mechtler K, Ponting CP, Allis CD and Jenuwein T.


book

Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter
Mol. Cell. Biol. 18 (5), 2535-2544 (1998)
El Kharroubi A, Piras G, Zensen R and Martin MA.


book

The human histone gene cluster at the D6S105 locus
Hum. Genet. 101 (3), 284-294 (1997)
Albig W and Doenecke D.


book

Human histone gene organization: nonregular arrangement within a large cluster
Genomics 40 (2), 314-322 (1997)
Albig W, Kioschis P, Poustka A, Meergans K and Doenecke D.


 
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