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HIST1H4D cDNA ORF clone, Homo sapiens (human)

Gene Symbol HIST1H4D
Entrez Gene ID 8360
Full Name histone cluster 1, H4d
Synonyms H4/b, H4FB, dJ221C16.9
General protein information
Preferred Names
histone H4
Names
histone H4
histone 1, H4d
H4 histone family, member B
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p22.2

Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]. lac of sum
Disorder MIM:

602823


mRNA and Protein(s)

mRNA Protein Name
NM_003539 NP_003530 histone H4



Homo sapiens (human) HIST1H4D NP_003530.1
Pan troglodytes (chimpanzee) LOC748513 XP_001172726.1
Macaca mulatta (Rhesus monkey) LOC704341 XP_001095996.1
Canis lupus familiaris (dog) LOC100856225 XP_003640212.1
Bos taurus (cattle) LOC100337407 XP_005226918.1
Mus musculus (house mouse) Hist1h4m NP_001182350.1
Rattus norvegicus (Norway rat) Hist2h4a XP_578415.2
Gallus gallus (chicken) HIST1H46L2 XP_003640416.1
Danio rerio (zebrafish) LOC100002181 XP_001336407.1
Drosophila melanogaster (fruit fly) His4:CG33891 NP_001027327.1
Caenorhabditis elegans his-60 NP_501203.2
Xenopus (Silurana) tropicalis (western clawed frog) LOC100495739 XP_002933940.1

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following HIST1H4D gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HIST1H4D cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu30175
NM_003539 Homo sapiens histone cluster 1, H4d (HIST1H4D), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
Starting from $49.50
$99.00

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu30175
Clone ID Related Accession (Same CDS sequence) NM_003539
Accession Version NM_003539.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 312bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-AUG-2015
Organism Homo sapiens (human)
Product histone H4
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X60482.1. On May 22, 2002 this sequence version replaced gi:5579463. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: CA406688.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
ATGTCTGGCC GCGGTAAGGG CGGAAAGGGT CTAGGTAAGG GTGGCGCCAA GCGTCACCGT 
AAGGTATTGC GTGACAATAT CCAAGGAATC ACCAAGCCCG CTATCCGCCG CCTGGCTCGC
CGCGGCGGCG TCAAGCGTAT TTCTGGCCTC ATTTATGAGG AAACTCGCGG AGTGCTGAAA
GTTTTCCTGG AAAATGTAAT CCGCGATGCT GTCACCTACA CGGAACACGC CAAACGCAAG
ACAGTCACAG CCATGGACGT GGTGTACGCG CTCAAGCGCC AGGGACGCAC TCTTTATGGC
TTCGGCGGCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_003530.1
CDS1..312
Misc Feature(1)1..309(+)
Misc Feature(2)4..6(+)
Misc Feature(3)4..6(+)
Misc Feature(4)10..12(+)
Misc Feature(5)10..12(+)
Misc Feature(6)16..18(+)
Misc Feature(7)16..18(+)
Misc Feature(8)25..27(+)
Misc Feature(9)25..27(+)
Misc Feature(10)37..39(+)
Misc Feature(11)37..39(+)
Misc Feature(12)49..51(+)
Misc Feature(13)49..51(+)
Misc Feature(14)52..303(+)
Misc Feature(15)61..63(+)
Misc Feature(16)94..96(+)
Misc Feature(17)100..273(+)
Misc Feature(18)121..135(+)
Misc Feature(19)133..291(+)
Misc Feature(20)142..144(+)
Misc Feature(21)154..156(+)
Misc Feature(22)205..279(+)
Misc Feature(23)265..267(+)
Misc Feature(24)274..276(+)
Misc Feature(25)274..276(+)
Misc Feature(26)289..303(+)
Exon (1)1..367
Gene:HIST1H4D
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_003539
Organism Homo sapiens (human)
Definition Homo sapiens histone cluster 1, H4d (HIST1H4D), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003539

ORF Insert Sequence:

1
61
121
181
241
301
ATGTCTGGCC GCGGTAAGGG CGGAAAGGGT CTAGGTAAGG GTGGCGCCAA GCGTCACCGT 
AAGGTATTGC GTGACAATAT CCAAGGAATC ACCAAGCCCG CTATCCGCCG CCTGGCTCGC
CGCGGCGGCG TCAAGCGTAT TTCTGGCCTC ATTTATGAGG AAACTCGCGG AGTGCTGAAA
GTTTTCCTGG AAAATGTAAT CCGCGATGCT GTCACCTACA CGGAACACGC CAAACGCAAG
ACAGTCACAG CCATGGACGT GGTGTACGCG CTCAAGCGCC AGGGACGCAC TCTTTATGGC
TTCGGCGGCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Human tNASP promotes in vitro nucleosome assembly with histone H3.3
Biochemistry 54 (5), 1171-1179 (2015)
Kato D, Osakabe A, Tachiwana H, Tanaka H and Kurumizaka H.


book

A proteome-scale map of the human interactome network
Cell 159 (5), 1212-1226 (2014)
Rolland T, Tasan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Trigg SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barabasi AL, Iakoucheva LM, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP and Vidal M.


book

Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain
FEBS Lett. 588 (21), 3844-3854 (2014)
Lubula MY, Eckenroth BE, Carlson S, Poplawski A, Chruszcz M and Glass KC.


book

Molecular functions of the TLE tetramerization domain in Wnt target gene repression
EMBO J. 33 (7), 719-731 (2014)
Chodaparambil JV, Pate KT, Hepler MR, Tsai BP, Muthurajan UM, Luger K, Waterman ML and Weis WI.


book

Structure of human nucleosome containing the testis-specific histone variant TSH2B
Acta Crystallogr F Struct Biol Commun 70 (PT 4), 444-449 (2014)
Urahama T, Horikoshi N, Osakabe A, Tachiwana H and Kurumizaka H.


book

The human and mouse replication-dependent histone genes
Genomics 80 (5), 487-498 (2002)
Marzluff WF, Gongidi P, Woods KR, Jin J and Maltais LJ.


book

The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes
Mol. Biol. Rep. 25 (1), 1-12 (1998)
Aziz F, van Wijnen AJ, Vaughan PS, Wu S, Shakoori AR, Lian JB, Soprano KJ, Stein JL and Stein GS.


book

The human histone gene cluster at the D6S105 locus
Hum. Genet. 101 (3), 284-294 (1997)
Albig W and Doenecke D.


book

Human histone gene organization: nonregular arrangement within a large cluster
Genomics 40 (2), 314-322 (1997)
Albig W, Kioschis P, Poustka A, Meergans K and Doenecke D.


book

Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene
Science 236 (4806), 1308-1311 (1987)
Pauli,U., Chrysogelos,S., Stein,G., Stein,J. and Nick,H.


 
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