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HIST1H4L cDNA ORF clone, Homo sapiens (human)

Gene Symbol HIST1H4L
Entrez Gene ID 8368
Full Name histone cluster 1, H4l
Synonyms H4.k, H4/k, H4FK
General protein information
Preferred Names
histone H4
Names
histone H4
histone 1, H4l
H4 histone family, member K
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p22.1

Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]. lac of sum
Disorder MIM:

602831

Disorder Html:

mRNA and Protein(s)

mRNA Protein Name
NM_003546 NP_003537 histone H4

KEGG
hsa05322 Systemic lupus erythematosus
hsa05203 Viral carcinogenesis
hsa05034 Alcoholism
Reactome
R-HSA-1643685 Disease
R-HSA-977225 Amyloid formation
R-HSA-162582 Signal Transduction
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-195721 Signaling by Wnt
R-HSA-74160 Gene Expression
R-HSA-73728 RNA Polymerase I Promoter Opening
R-HSA-504046 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
R-HSA-73777 RNA Polymerase I Chain Elongation
R-HSA-73854 RNA Polymerase I Promoter Clearance
R-HSA-73864 RNA Polymerase I Transcription
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-1640170 Cell Cycle
R-HSA-211000 Gene Silencing by RNA
R-HSA-212165 Epigenetic regulation of gene expression
R-HSA-5250941 Negative epigenetic regulation of rRNA expression
R-HSA-427359 SIRT1 negatively regulates rRNA Expression
R-HSA-5334118 DNA methylation
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-68875 Mitotic Prophase
R-HSA-68886 M Phase
R-HSA-2299718 Condensation of Prophase Chromosomes
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-212300 PRC2 methylates histones and DNA
R-HSA-69481 G2/M Checkpoints
R-HSA-69473 G2/M DNA damage checkpoint
R-HSA-1500620 Meiosis
R-HSA-1221632 Meiotic synapsis
R-HSA-157579 Telomere Maintenance
R-HSA-912446 Meiotic recombination
R-HSA-171306 Packaging Of Telomere Ends
R-HSA-73886 Chromosome Maintenance
R-HSA-774815 Nucleosome assembly
R-HSA-2262752 Cellular responses to stress
R-HSA-4839726 Chromatin organization
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-3214847 HATs acetylate histones
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559583 Cellular Senescence
R-HSA-3214842 HDMs demethylate histones
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-3214815 HDACs deacetylate histones
R-HSA-3214858 RMTs methylate histone arginines
Pathway Interaction Database
hdac_classiii_pathway Signaling events mediated by HDAC Class III
WikiPathways
WP619 Type II interferon signaling (IFNG)
WP2361 Gastric cancer network 1


Homo sapiens (human) HIST1H4L NP_003537.1
Pan troglodytes (chimpanzee) LOC735611 XP_001134995.1
Macaca mulatta (Rhesus monkey) LOC698354 XP_001087948.1
Canis lupus familiaris (dog) LOC488260 XP_005640157.1
Bos taurus (cattle) LOC530773 NP_001139343.1
Mus musculus (house mouse) Hist1h4n NP_783588.1
Rattus norvegicus (Norway rat) LOC100912290 XP_003749898.1
Danio rerio (zebrafish) LOC101882398 XP_005163249.1
Drosophila melanogaster (fruit fly) His4r NP_001262576.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100485962 XP_002944234.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following HIST1H4L gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HIST1H4L cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu30263 NM_003546 Homo sapiens histone cluster 1, H4l (HIST1H4L), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu30263
Accession Version NM_003546.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 312bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 18-AUG-2015
Organism Homo sapiens (human)
Product histone H4
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X83548.1. On Sep 21, 2001 this sequence version replaced gi:4504316. Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC069392.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
ATGTCTGGGC GCGGCAAAGG CGGGAAGGGT CTGGGCAAAG GAGGCGCTAA GCGCCACCGC 
AAAGTTCTGC GCGACAACAT TCAGGGCATC ACCAAGCCCG CCATCCGACG CCTGGCACGG
CGTGGAGGCG TTAAGCGCAT CTCAGGCCTT ATATACGAGG AGACACGCGG AGTTCTTAAA
GTGTTTTTGG AGAATGTAAT CCGCGATGCA GTTACCTACA CGGAGCACGC CAAACGCAAG
ACAGTCACAG CCATGGACGT GGTTTACGCG CTCAAGCGCC AGGGCCGCAC CCTGTATGGC
TTTGGCGGCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_003537.1
CDS2..313
Misc Feature(1)2..310(+)
Misc Feature(2)5..7(+)
Misc Feature(3)5..7(+)
Misc Feature(4)11..13(+)
Misc Feature(5)11..13(+)
Misc Feature(6)17..19(+)
Misc Feature(7)17..19(+)
Misc Feature(8)26..28(+)
Misc Feature(9)26..28(+)
Misc Feature(10)38..40(+)
Misc Feature(11)38..40(+)
Misc Feature(12)50..52(+)
Misc Feature(13)50..52(+)
Misc Feature(14)53..304(+)
Misc Feature(15)62..64(+)
Misc Feature(16)95..97(+)
Misc Feature(17)101..274(+)
Misc Feature(18)122..136(+)
Misc Feature(19)134..292(+)
Misc Feature(20)143..145(+)
Misc Feature(21)155..157(+)
Misc Feature(22)206..280(+)
Misc Feature(23)266..268(+)
Misc Feature(24)275..277(+)
Misc Feature(25)275..277(+)
Misc Feature(26)290..304(+)
Exon (1)1..364
Gene:HIST1H4L
Gene Synonym:
Translation
Position Chain Variation Link
1 1 c, t dbSNP:767523621
2 2 a, g dbSNP:374170402
3 3 c, t dbSNP:773941586
5 5 c, t dbSNP:768207393
6 6 c, t dbSNP:754542034
7 7 c, t dbSNP:762408618
8 8 g, t dbSNP:775183683
9 9 g, t dbSNP:769352299
12 12 g, t dbSNP:747356743
13 13 c, t dbSNP:543992847
14 14 a, g dbSNP:751027005
20 20 a, g dbSNP:748644823
21 21 a, g dbSNP:779467968
28 28 a, g dbSNP:370191129
32 32 c, t dbSNP:372118009
42 42 c, g dbSNP:749379914
49 49 c, t dbSNP:780276110
52 52 c, g dbSNP:756323099
55 55 c, t dbSNP:146951768
62 62 a, t dbSNP:45510393
77 77 a, g dbSNP:767433753
79 79 c, t dbSNP:757185863
81 81 c, t dbSNP:558322685
82 82 g, t dbSNP:751510110
83 83 c, t dbSNP:763986779
84 84 a, t dbSNP:141965015
85 85 a, g dbSNP:765956793
86 86 a, g dbSNP:774891674
88 88 c, t dbSNP:764874592
90 90 c, t dbSNP:148131091
91 91 c, t dbSNP:759196470
93 93 a, c dbSNP:776319064
97 97 a, g dbSNP:772425723
97 97 -, g dbSNP:777038299
101 101 a, g, t dbSNP:774821045
103 103 c, t dbSNP:769068386
107 107 a, c dbSNP:749350646
108 108 g, t dbSNP:200857174
109 109 a, g dbSNP:756302249
111 111 a, g dbSNP:746075343
113 113 c, t dbSNP:781605592
115 115 a, g dbSNP:757095954
118 118 a, g dbSNP:751420095
121 121 a, g dbSNP:764049508
141 141 a, t dbSNP:758269902
142 142 c, t dbSNP:143831887
147 147 a, g dbSNP:764635508
148 148 a, c dbSNP:759118398
153 153 c, t dbSNP:776239022
157 157 c, t dbSNP:572718363
161 161 a, g dbSNP:148995564
168 168 g, t dbSNP:774611745
169 169 c, t dbSNP:769141476
170 170 a, g dbSNP:146790408
173 173 c, g dbSNP:552991432
177 177 c, t dbSNP:769963455
178 178 c, t dbSNP:375181706
180 180 -, aa dbSNP:771098943
181 181 a, c, g dbSNP:771307672
183 183 g, t dbSNP:746732358
184 184 g, t dbSNP:777439995
196 196 a, c, t dbSNP:752569046
202 202 c, t dbSNP:371094647
208 208 c, t dbSNP:200165469
215 215 -, aa dbSNP:747104571
218 218 g, t dbSNP:567954872
220 220 c, t dbSNP:765978826
221 221 a, g dbSNP:374614068
222 222 c, t dbSNP:751895604
223 223 a, g dbSNP:557626056
229 229 -, c dbSNP:772960759
236 236 c, g dbSNP:537599294
237 237 c, g dbSNP:775836737
238 238 c, t dbSNP:770446787
240 240 a, g dbSNP:759646590
241 241 a, g dbSNP:761113259
246 246 c, t dbSNP:776852434
249 249 c, t dbSNP:571715805
253 253 c, t dbSNP:776193225
255 255 c, t dbSNP:145023904
258 258 a, g dbSNP:201833445
259 259 c, t dbSNP:771737600
267 267 -, a dbSNP:772049023
270 270 c, t dbSNP:748028918
271 271 a, g dbSNP:778775510
271 271 -, g dbSNP:748098076
274 274 c, t dbSNP:754943535
278 278 c, g dbSNP:753279577
279 279 a, g dbSNP:200412707
287 287 c, t dbSNP:779555905
291 291 a, c dbSNP:755679155
295 295 a, g dbSNP:750041069
301 301 c, t dbSNP:199627146
306 306 a, g dbSNP:763177767
308 308 a, g dbSNP:45526033
322 322 c, t dbSNP:146526966
323 323 c, t dbSNP:372443028
324 324 c, t dbSNP:539846229
327 327 -, ttac dbSNP:535818107
333 333 c, g dbSNP:766557945
338 338 c, t dbSNP:760845310
342 342 -, aa dbSNP:754775900
348 348 c, t dbSNP:773288079
349 349 c, t dbSNP:772365722
351 351 c, g, t dbSNP:199543389
354 354 a, g dbSNP:749571809
359 359 c, t dbSNP:768523794
362 362 c, t dbSNP:749211973
364 364 a, g dbSNP:45509595

Target ORF information:

RefSeq Version NM_003546
Organism Homo sapiens (human)
Definition Homo sapiens histone cluster 1, H4l (HIST1H4L), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003546

ORF Insert Sequence:

1
61
121
181
241
301
ATGTCTGGGC GCGGCAAAGG CGGGAAGGGT CTGGGCAAAG GAGGCGCTAA GCGCCACCGC 
AAAGTTCTGC GCGACAACAT TCAGGGCATC ACCAAGCCCG CCATCCGACG CCTGGCACGG
CGTGGAGGCG TTAAGCGCAT CTCAGGCCTT ATATACGAGG AGACACGCGG AGTTCTTAAA
GTGTTTTTGG AGAATGTAAT CCGCGATGCA GTTACCTACA CGGAGCACGC CAAACGCAAG
ACAGTCACAG CCATGGACGT GGTTTACGCG CTCAAGCGCC AGGGCCGCAC CCTGTATGGC
TTTGGCGGCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Human tNASP promotes in vitro nucleosome assembly with histone H3.3
Biochemistry 54 (5), 1171-1179 (2015)
Kato D, Osakabe A, Tachiwana H, Tanaka H and Kurumizaka H.


book

A proteome-scale map of the human interactome network
Cell 159 (5), 1212-1226 (2014)
Rolland T, Tasan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Trigg SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barabasi AL, Iakoucheva LM, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP and Vidal M.


book

Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain
FEBS Lett. 588 (21), 3844-3854 (2014)
Lubula MY, Eckenroth BE, Carlson S, Poplawski A, Chruszcz M and Glass KC.


book

Molecular functions of the TLE tetramerization domain in Wnt target gene repression
EMBO J. 33 (7), 719-731 (2014)
Chodaparambil JV, Pate KT, Hepler MR, Tsai BP, Muthurajan UM, Luger K, Waterman ML and Weis WI.


book

Structure of human nucleosome containing the testis-specific histone variant TSH2B
Acta Crystallogr F Struct Biol Commun 70 (PT 4), 444-449 (2014)
Urahama T, Horikoshi N, Osakabe A, Tachiwana H and Kurumizaka H.


book

The human and mouse replication-dependent histone genes
Genomics 80 (5), 487-498 (2002)
Marzluff WF, Gongidi P, Woods KR, Jin J and Maltais LJ.


book

The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes
Mol. Biol. Rep. 25 (1), 1-12 (1998)
Aziz F, van Wijnen AJ, Vaughan PS, Wu S, Shakoori AR, Lian JB, Soprano KJ, Stein JL and Stein GS.


book

The human histone gene cluster at the D6S105 locus
Hum. Genet. 101 (3), 284-294 (1997)
Albig W and Doenecke D.


book

Characterization of the H1.5 gene completes the set of human H1 subtype genes
Gene 184 (2), 141-148 (1997)
Albig W, Meergans T and Doenecke D.


book

Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene
Science 236 (4806), 1308-1311 (1987)
Pauli,U., Chrysogelos,S., Stein,G., Stein,J. and Nick,H.


 
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