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HIST1H4L cDNA ORF clone, Homo sapiens (human)

Gene Symbol HIST1H4L
Entrez Gene ID 8368
Full Name histone cluster 1, H4l
Synonyms H4.k, H4/k, H4FK
General protein information
Preferred Names
histone H4
Names
histone H4
histone 1, H4l
H4 histone family, member K
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p22.1

Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]. lac of sum
Disorder MIM:

602831


mRNA and Protein(s)

mRNA Protein Name
NM_003546 NP_003537 histone H4



Homo sapiens (human) HIST1H4L NP_003537.1
Pan troglodytes (chimpanzee) LOC735611 XP_001134995.1
Macaca mulatta (Rhesus monkey) LOC698354 XP_001087948.1
Canis lupus familiaris (dog) LOC488260 XP_005640157.1
Bos taurus (cattle) LOC530773 NP_001139343.1
Mus musculus (house mouse) Hist1h4n NP_783588.1
Rattus norvegicus (Norway rat) LOC100912290 XP_003749898.1
Danio rerio (zebrafish) LOC101882398 XP_005163249.1
Drosophila melanogaster (fruit fly) His4r NP_001262576.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100485962 XP_002944234.1

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following HIST1H4L gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HIST1H4L cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu30263
NM_003546 Homo sapiens histone cluster 1, H4l (HIST1H4L), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu30263
Clone ID Related Accession (Same CDS sequence) NM_003546
Accession Version NM_003546.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 312bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 18-AUG-2015
Organism Homo sapiens (human)
Product histone H4
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X83548.1. On Sep 21, 2001 this sequence version replaced gi:4504316. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC069392.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
ATGTCTGGGC GCGGCAAAGG CGGGAAGGGT CTGGGCAAAG GAGGCGCTAA GCGCCACCGC 
AAAGTTCTGC GCGACAACAT TCAGGGCATC ACCAAGCCCG CCATCCGACG CCTGGCACGG
CGTGGAGGCG TTAAGCGCAT CTCAGGCCTT ATATACGAGG AGACACGCGG AGTTCTTAAA
GTGTTTTTGG AGAATGTAAT CCGCGATGCA GTTACCTACA CGGAGCACGC CAAACGCAAG
ACAGTCACAG CCATGGACGT GGTTTACGCG CTCAAGCGCC AGGGCCGCAC CCTGTATGGC
TTTGGCGGCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_003537.1
CDS2..313
Misc Feature(1)2..310(+)
Misc Feature(2)5..7(+)
Misc Feature(3)5..7(+)
Misc Feature(4)11..13(+)
Misc Feature(5)11..13(+)
Misc Feature(6)17..19(+)
Misc Feature(7)17..19(+)
Misc Feature(8)26..28(+)
Misc Feature(9)26..28(+)
Misc Feature(10)38..40(+)
Misc Feature(11)38..40(+)
Misc Feature(12)50..52(+)
Misc Feature(13)50..52(+)
Misc Feature(14)53..304(+)
Misc Feature(15)62..64(+)
Misc Feature(16)95..97(+)
Misc Feature(17)101..274(+)
Misc Feature(18)122..136(+)
Misc Feature(19)134..292(+)
Misc Feature(20)143..145(+)
Misc Feature(21)155..157(+)
Misc Feature(22)206..280(+)
Misc Feature(23)266..268(+)
Misc Feature(24)275..277(+)
Misc Feature(25)275..277(+)
Misc Feature(26)290..304(+)
Exon (1)1..364
Gene:HIST1H4L
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_003546
Organism Homo sapiens (human)
Definition Homo sapiens histone cluster 1, H4l (HIST1H4L), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003546

ORF Insert Sequence:

1
61
121
181
241
301
ATGTCTGGGC GCGGCAAAGG CGGGAAGGGT CTGGGCAAAG GAGGCGCTAA GCGCCACCGC 
AAAGTTCTGC GCGACAACAT TCAGGGCATC ACCAAGCCCG CCATCCGACG CCTGGCACGG
CGTGGAGGCG TTAAGCGCAT CTCAGGCCTT ATATACGAGG AGACACGCGG AGTTCTTAAA
GTGTTTTTGG AGAATGTAAT CCGCGATGCA GTTACCTACA CGGAGCACGC CAAACGCAAG
ACAGTCACAG CCATGGACGT GGTTTACGCG CTCAAGCGCC AGGGCCGCAC CCTGTATGGC
TTTGGCGGCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Human tNASP promotes in vitro nucleosome assembly with histone H3.3
Biochemistry 54 (5), 1171-1179 (2015)
Kato D, Osakabe A, Tachiwana H, Tanaka H and Kurumizaka H.


book

A proteome-scale map of the human interactome network
Cell 159 (5), 1212-1226 (2014)
Rolland T, Tasan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Trigg SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barabasi AL, Iakoucheva LM, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP and Vidal M.


book

Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain
FEBS Lett. 588 (21), 3844-3854 (2014)
Lubula MY, Eckenroth BE, Carlson S, Poplawski A, Chruszcz M and Glass KC.


book

Molecular functions of the TLE tetramerization domain in Wnt target gene repression
EMBO J. 33 (7), 719-731 (2014)
Chodaparambil JV, Pate KT, Hepler MR, Tsai BP, Muthurajan UM, Luger K, Waterman ML and Weis WI.


book

Structure of human nucleosome containing the testis-specific histone variant TSH2B
Acta Crystallogr F Struct Biol Commun 70 (PT 4), 444-449 (2014)
Urahama T, Horikoshi N, Osakabe A, Tachiwana H and Kurumizaka H.


book

The human and mouse replication-dependent histone genes
Genomics 80 (5), 487-498 (2002)
Marzluff WF, Gongidi P, Woods KR, Jin J and Maltais LJ.


book

The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes
Mol. Biol. Rep. 25 (1), 1-12 (1998)
Aziz F, van Wijnen AJ, Vaughan PS, Wu S, Shakoori AR, Lian JB, Soprano KJ, Stein JL and Stein GS.


book

The human histone gene cluster at the D6S105 locus
Hum. Genet. 101 (3), 284-294 (1997)
Albig W and Doenecke D.


book

Characterization of the H1.5 gene completes the set of human H1 subtype genes
Gene 184 (2), 141-148 (1997)
Albig W, Meergans T and Doenecke D.


book

Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene
Science 236 (4806), 1308-1311 (1987)
Pauli,U., Chrysogelos,S., Stein,G., Stein,J. and Nick,H.


 
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