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RNASEH2C ribonuclease H2, subunit C [Homo sapiens (human)]

Gene Symbol RNASEH2C
Entrez Gene ID 84153
Full Name ribonuclease H2, subunit C
Synonyms AGS3, AYP1
General protein information
Preferred Names
ribonuclease H2 subunit C
Names
ribonuclease H2 subunit C
RNase H2 subunit C
RNase H1 small subunit
ribonuclease HI subunit C
aicardi-Goutieres syndrome 3 protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q13.1

Summary This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

610330

Disorder Html: Aicardi-Goutieres syndrome 3, 610329 (3)





The following RNASEH2C gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RNASEH2C gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu20612 NM_032193 Homo sapiens ribonuclease H2, subunit C (RNASEH2C), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $99

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu20612
Accession Version NM_032193.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 495bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product ribonuclease H2 subunit C
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF346606.1, BC023588.2, AP001266.4 and BC000831.1. This sequence is a reference standard in the RefSeqGene project. On Aug 25, 2006 this sequence version replaced gi:38176284. Summary: This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AF346606.1, BX353248.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
ATGGAGAGCG GCGACGAAGC GGCCATCGAG AGGCACCGCG TCCACTTGCG CTCCGCCACA 
TTGCGCGACG CCGTACCCGC CACACTGCAT CTGCTGCCCT GCGAGGTTGC GGTGGACGGG
CCCGCCCCGG TGGGGCGCTT CTTCACGCCC GCCATCCGCC AGGGCCCCGA GGGACTCGAA
GTGTCGTTTC GGGGCCGCTG TCTACGGGGA GAGGAGGTGG CGGTGCCGCC TGGCCTCGTG
GGATACGTGA TGGTGACAGA AGAGAAGAAG GTGTCGATGG GGAAGCCAGA CCCCTTGCGG
GATTCCGGGA CTGACGACCA AGAGGAGGAG CCGCTGGAGC GGGACTTCGA CCGCTTCATT
GGAGCCACTG CCAACTTCAG CCGCTTCACC CTGTGGGGTC TGGAGACCAT CCCTGGCCCG
GATGCCAAAG TGCGTGGGGC CTTAACTTGG CCCAGCCTTG CGGCAGCGAT TCACGCACAG
GTGCCCGAGG ACTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_115569.2
CDS181..675
Misc Feature(1)64..66(+)
Misc Feature(2)181..183(+)
Misc Feature(3)268..585(+)
Misc Feature(4)268..432(+)
Exon (1)1..352
Gene:RNASEH2C
Gene Synonym:
Exon (2)353..528
Gene:RNASEH2C
Gene Synonym:
Exon (3)529..648
Gene:RNASEH2C
Gene Synonym:
Exon (4)649..2785
Gene:RNASEH2C
Gene Synonym:
Translation
Position Chain Variation Link
15 15 a, g dbSNP:558099940
24 24 a, c dbSNP:535406222
43 43 a, g dbSNP:569699587
132 132 c, g dbSNP:775918910
137 137 c, t dbSNP:375056059
143 143 c, t dbSNP:769979857
148 148 a, g dbSNP:759699476
152 152 c, g dbSNP:777126717
154 154 a, g, t dbSNP:549471118
157 157 c, t dbSNP:777972070
162 162 c, g dbSNP:772496571
167 167 g, t dbSNP:201160941
168 168 c, t dbSNP:778552316
170 170 c, t dbSNP:370728253
171 171 a, g dbSNP:77371161
172 172 a, g dbSNP:779993198
186 186 a, g dbSNP:755982930
198 198 a, g dbSNP:750414368
200 200 c, t dbSNP:767413437
201 201 a, g, t dbSNP:752906159
215 215 a, g dbSNP:765558776
217 217 -, c dbSNP:773063301
218 218 a, g dbSNP:75328625
223 223 c, t dbSNP:759644653
227 227 g, t dbSNP:776593619
228 228 -, g dbSNP:772074076
228 228 g, t dbSNP:771086438
232 232 c, t dbSNP:77213730
234 234 c, t dbSNP:761086146
236 236 c, g dbSNP:773830258
241 241 c, t dbSNP:376140250
245 245 a, g dbSNP:748517989
247 247 a, g dbSNP:778499260
248 248 a, g dbSNP:768320493
249 249 c, t dbSNP:749020058
251 251 c, t dbSNP:779399624
252 252 c, t dbSNP:755716409
255 255 a, c dbSNP:750312611
265 265 c, t dbSNP:781290873
267 267 c, g dbSNP:757043364
268 268 c, t dbSNP:751428290
278 278 c, t dbSNP:11557810
284 284 a, g dbSNP:374512840
285 285 a, g dbSNP:759651650
291 291 g, t dbSNP:754159872
293 293 c, t dbSNP:766360075
295 295 a, g, t dbSNP:773527127
302 302 c, t dbSNP:768044949
309 309 a, g, t dbSNP:774676282
313 313 a, g dbSNP:527618427
327 327 g, t dbSNP:565075244
343 343 c, g dbSNP:748888378
347 347 c, g dbSNP:775269637
349 349 a, g dbSNP:769127379
352 352 a, g dbSNP:544915618
353 353 c, g dbSNP:753125608
354 354 a, c dbSNP:765566693
355 355 a, c dbSNP:764887792
356 356 c, t dbSNP:776487895
358 358 -, g dbSNP:772940104
370 370 a, c, t dbSNP:760270515
372 372 g, t dbSNP:772987116
374 374 a, g dbSNP:554234154
375 375 a, c dbSNP:748085204
378 378 c, t dbSNP:200792226
385 385 c, t dbSNP:78635798
387 387 c, g dbSNP:540910513
391 391 a, g dbSNP:781404325
393 393 a, g dbSNP:372999020
395 395 a, t dbSNP:751668441
398 398 c, t dbSNP:778089123
407 407 c, t dbSNP:76091978
408 408 c, g dbSNP:753182283
411 411 c, t dbSNP:765627576
413 413 c, g dbSNP:558325124
418 418 a, c, g dbSNP:766165208
426 426 c, t dbSNP:760217364
427 427 a, g dbSNP:772757667
439 439 a, g dbSNP:771525032
443 443 -, aga dbSNP:376387465
448 448 -, aag dbSNP:141875736
448 448 a, g dbSNP:200659526
449 449 a, c, t dbSNP:772347588
457 457 a, t dbSNP:749085392
460 460 a, g dbSNP:781351230
469 469 g, t dbSNP:771160923
472 472 c, g, t dbSNP:148186114
473 473 c, t dbSNP:758470933
481 481 g, t dbSNP:753193179
485 485 c, t dbSNP:779295406
486 486 c, t dbSNP:369078297
487 487 a, c, g dbSNP:766900205
489 489 c, g dbSNP:755797271
506 506 a, g dbSNP:750112149
508 508 -, gag dbSNP:757678258
508 508 a, c, g dbSNP:759057632
509 509 a, c dbSNP:774276399
512 512 c, t dbSNP:113396656
514 514 c, t dbSNP:764049021
516 516 a, g dbSNP:762686846
517 517 c, g dbSNP:753752195
520 520 a, c dbSNP:775240118
523 523 a, g dbSNP:769612292
529 529 g, t dbSNP:768923856
532 532 c, g dbSNP:749800813
533 533 c, g dbSNP:375915791
538 538 a, g dbSNP:145783593
539 539 c, t dbSNP:547025312
542 542 a, g dbSNP:780848408
547 547 a, t dbSNP:756837367
548 548 c, t dbSNP:548212597
551 551 c, t dbSNP:751248914
554 554 a, g dbSNP:143452727
561 561 c, t dbSNP:777256233
573 573 a, g dbSNP:138181714
579 579 a, t dbSNP:752570194
585 585 a, g dbSNP:765193046
592 592 c, t dbSNP:77834781
597 597 c, g dbSNP:147021687
606 606 c, t dbSNP:753557040
608 608 a, t dbSNP:75146158
613 613 c, t dbSNP:761938235
614 614 g, t dbSNP:774773395
615 615 c, t dbSNP:768800996
617 617 a, g dbSNP:763128012
618 618 a, g dbSNP:776098553
628 628 c, t dbSNP:770225181
631 631 c, t dbSNP:78464826
635 635 a, g dbSNP:781376271
636 636 c, t dbSNP:551663637
637 637 c, g dbSNP:3178149
639 639 c, t dbSNP:771390677
641 641 c, t dbSNP:746647905
642 642 g, t dbSNP:777413965
643 643 a, g dbSNP:757866333
648 648 g, t dbSNP:61736590
650 650 c, t dbSNP:769367289
652 652 c, t dbSNP:759118175
654 654 c, t dbSNP:776668184
656 656 c, t dbSNP:560684217
658 658 a, c dbSNP:771013055
663 663 a, g dbSNP:746962853
664 664 c, t dbSNP:751182876
669 669 a, g dbSNP:373524507
671 671 a, g dbSNP:771823743
675 675 a, c dbSNP:749473518
684 684 a, g dbSNP:780260172
689 689 a, c dbSNP:756147712
699 699 c, t dbSNP:750525397
706 706 c, t dbSNP:781300192
708 708 c, t dbSNP:757749372
717 717 -, ttg dbSNP:767413227
717 717 a, t dbSNP:752072296
719 719 -, ta dbSNP:761736416
727 727 c, t dbSNP:377308428
729 729 a, c, t dbSNP:752329713
735 735 a, g dbSNP:765012427
738 738 c, t dbSNP:759066849
739 739 g, t dbSNP:776252408
796 796 c, g dbSNP:770268649
802 802 c, t dbSNP:535928573
830 830 c, t dbSNP:749853881
851 851 c, t dbSNP:573443484
853 853 c, t dbSNP:3180585
855 855 a, g dbSNP:563118937
859 859 c, t dbSNP:553350030
863 863 a, g dbSNP:3177082
878 878 a, c dbSNP:533513209
881 881 c, g dbSNP:571237955
889 889 a, g dbSNP:746356096
891 891 a, g dbSNP:543443105
930 930 a, c dbSNP:199982885
933 933 c, g dbSNP:554051
943 943 c, g dbSNP:551357593
962 962 c, t dbSNP:533998697
970 970 c, t dbSNP:538167829
985 985 c, t dbSNP:190723966
992 992 c, t dbSNP:549238084
1007 1007 c, t dbSNP:529399711
1035 1035 c, t dbSNP:560522377
1038 1038 c, t dbSNP:547082810
1046 1046 c, t dbSNP:375782368
1049 1049 g, t dbSNP:533143132
1060 1060 a, c dbSNP:757672652
1083 1083 c, t dbSNP:564528337
1101 1101 c, t dbSNP:532874020
1115 1115 c, g dbSNP:544558074
1127 1127 a, g dbSNP:575568290
1131 1131 a, g dbSNP:561937926
1199 1199 a, g dbSNP:542065582
1203 1203 a, g dbSNP:564250796
1210 1210 c, t dbSNP:573105388
1216 1216 c, t dbSNP:756513194
1217 1217 a, g dbSNP:186106053
1227 1227 a, g dbSNP:370375120
1230 1230 a, g dbSNP:760648317
1237 1237 a, g dbSNP:773038059
1239 1239 a, c dbSNP:771838298
1245 1245 a, g dbSNP:201309659
1247 1247 c, t dbSNP:200332583
1248 1248 a, g dbSNP:199779470
1249 1249 c, t dbSNP:769984873
1261 1261 a, g dbSNP:746126549
1263 1263 c, t dbSNP:781241858
1276 1276 -, g dbSNP:774405578
1278 1278 c, t dbSNP:757335339
1304 1304 c, t dbSNP:747487385
1319 1319 c, t dbSNP:778146398
1321 1321 c, g dbSNP:537738482
1323 1323 c, t dbSNP:758749497
1331 1331 a, g, t dbSNP:11385
1333 1333 c, t dbSNP:199674306
1338 1338 c, t dbSNP:766235454
1339 1339 a, g dbSNP:753132884
1348 1348 a, g dbSNP:765743840
1352 1352 c, g dbSNP:754675864
1354 1354 a, g dbSNP:555699888
1356 1356 a, g dbSNP:145568166
1378 1378 c, t dbSNP:760107601
1379 1379 a, g dbSNP:773165524
1400 1400 g, t dbSNP:767381478
1415 1415 g, t dbSNP:761790368
1418 1418 a, g dbSNP:372541825
1422 1422 a, g dbSNP:201326733
1426 1426 c, t dbSNP:746073066
1441 1441 a, g dbSNP:200340458
1456 1456 a, t dbSNP:770976093
1459 1459 c, g dbSNP:747089650
1472 1472 -, c dbSNP:768739861
1479 1479 c, g dbSNP:760736986
1519 1519 a, g dbSNP:750349906
1523 1523 c, t dbSNP:200625753
1540 1540 a, g dbSNP:779408582
1590 1590 a, g dbSNP:755408654
1591 1591 a, g dbSNP:373553703
1594 1594 a, g dbSNP:369678311
1601 1601 c, g dbSNP:755605852
1610 1610 c, g dbSNP:749881907
1615 1615 a, g dbSNP:767097041
1623 1623 -, t dbSNP:142614068
1634 1634 a, g dbSNP:376685881
1643 1643 -, gaga dbSNP:369903559
1647 1647 -, gaga dbSNP:775646061
1656 1656 c, g dbSNP:774327054
1659 1659 a, g dbSNP:763815597
1660 1660 a, t dbSNP:372421554
1666 1666 a, c dbSNP:762736227
1673 1673 c, t dbSNP:776873216
1678 1678 c, g, t dbSNP:761005723
1680 1680 c, t dbSNP:773132471
1682 1682 c, g dbSNP:112903919
1683 1683 a, c dbSNP:748609095
1688 1688 a, g dbSNP:779568720
1690 1690 c, t dbSNP:201467701
1692 1692 a, g dbSNP:4645938
1698 1698 a, g dbSNP:375354165
1700 1700 c, t dbSNP:371125154
1703 1703 a, g dbSNP:768861396
1717 1717 c, g dbSNP:368492530
1735 1735 a, g dbSNP:114460328
1736 1736 a, c dbSNP:375524599
1737 1737 a, t dbSNP:780551642
1741 1741 c, t dbSNP:756770552
1742 1742 a, g dbSNP:751428495
1747 1747 c, t dbSNP:150212692
1753 1753 c, t dbSNP:762943848
1767 1767 a, g dbSNP:370970433
1781 1781 c, t dbSNP:752411616
1784 1784 c, t dbSNP:765118347
1791 1791 a, g dbSNP:760797089
1792 1792 a, g dbSNP:773497425
1810 1810 a, g dbSNP:772212913
1831 1831 a, g dbSNP:762014707
1837 1837 c, t dbSNP:11227272
1843 1843 c, t dbSNP:769267207
1855 1855 c, g dbSNP:749844512
1867 1867 a, g dbSNP:555206742
1874 1874 a, g dbSNP:376447456
1875 1875 c, t dbSNP:770248485
1878 1878 c, t dbSNP:745451443
1880 1880 -, g dbSNP:769854027
1882 1882 a, g dbSNP:531106902
1884 1884 a, g dbSNP:780822604
1885 1885 a, g dbSNP:756711910
1891 1891 a, g dbSNP:751091381
1895 1895 a, g dbSNP:561998272
1896 1896 c, g dbSNP:758299499
1898 1898 a, t dbSNP:752745337
1900 1900 a, g dbSNP:542132990
1903 1903 a, g dbSNP:759381325
1906 1906 a, g dbSNP:750571826
1909 1909 a, g dbSNP:767875510
1910 1910 a, g dbSNP:762179959
1911 1911 g, t dbSNP:774544891
1956 1956 c, t dbSNP:528634366
1970 1970 c, t dbSNP:4645937
2053 2053 a, g dbSNP:746434462
2057 2057 a, g dbSNP:539934831
2060 2060 a, g dbSNP:568311009
2073 2073 a, g dbSNP:777099295
2080 2080 c, g dbSNP:777245010
2113 2113 a, g dbSNP:557463955
2149 2149 g, t dbSNP:544178067
2175 2175 a, c dbSNP:575319291
2178 2178 a, g dbSNP:11542655
2197 2197 a, t dbSNP:189914247
2202 2202 -, a dbSNP:111942442
2202 2202 a, c dbSNP:521678
2207 2207 a, g dbSNP:376966597
2231 2231 -, g dbSNP:551349019
2257 2257 a, t dbSNP:553169571
2264 2264 c, t dbSNP:752366293
2269 2269 a, g dbSNP:761492773
2277 2277 a, g dbSNP:765170112
2296 2296 a, g dbSNP:373799308
2331 2331 c, t dbSNP:570973055
2344 2344 c, t dbSNP:550799723
2346 2346 a, g dbSNP:754592896
2355 2355 a, t dbSNP:145210355
2359 2359 a, g dbSNP:754804969
2369 2369 c, g dbSNP:530774610
2374 2374 c, g dbSNP:149989742
2395 2395 a, t dbSNP:779676428
2396 2396 c, g dbSNP:548451585
2399 2399 a, g dbSNP:186500846
2404 2404 a, g dbSNP:374457617
2422 2422 c, t dbSNP:750403211
2451 2451 c, t dbSNP:4645936
2459 2459 c, t dbSNP:757055361
2486 2486 c, t dbSNP:559681426
2494 2494 g, t dbSNP:751285332
2517 2517 a, g dbSNP:766342524
2542 2542 a, g dbSNP:763788370
2572 2572 a, c dbSNP:546422369
2588 2588 c, t dbSNP:532599256
2591 2591 c, g dbSNP:775550491
2592 2592 c, t dbSNP:535111
2634 2634 c, t dbSNP:549790841
2655 2655 c, t dbSNP:4645935
2666 2666 -, tctg dbSNP:773360162
2669 2669 c, g dbSNP:575287669
2710 2710 c, t dbSNP:397839539
2711 2711 c, t dbSNP:3372
2725 2725 c, g dbSNP:542132027
2738 2738 a, c dbSNP:771507716
2748 2748 c, t dbSNP:140429628
2758 2758 c, g dbSNP:762076103
2761 2761 a, g dbSNP:773697307
2772 2772 c, t dbSNP:4645934

Target ORF information:

RefSeq Version NM_032193
Organism Homo sapiens (human)
Definition Homo sapiens ribonuclease H2, subunit C (RNASEH2C), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_032193

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGAGAGCG GCGACGAAGC GGCCATCGAG AGGCACCGCG TCCACTTGCG CTCCGCCACA 
TTGCGCGACG CCGTACCCGC CACACTGCAT CTGCTGCCCT GCGAGGTTGC GGTGGACGGG
CCCGCCCCGG TGGGGCGCTT CTTCACGCCC GCCATCCGCC AGGGCCCCGA GGGACTCGAA
GTGTCGTTTC GGGGCCGCTG TCTACGGGGA GAGGAGGTGG CGGTGCCGCC TGGCCTCGTG
GGATACGTGA TGGTGACAGA AGAGAAGAAG GTGTCGATGG GGAAGCCAGA CCCCTTGCGG
GATTCCGGGA CTGACGACCA AGAGGAGGAG CCGCTGGAGC GGGACTTCGA CCGCTTCATT
GGAGCCACTG CCAACTTCAG CCGCTTCACC CTGTGGGGTC TGGAGACCAT CCCTGGCCCG
GATGCCAAAG TGCGTGGGGC CTTAACTTGG CCCAGCCTTG CGGCAGCGAT TCACGCACAG
GTGCCCGAGG ACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.