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MAF1 MAF1 homolog, negative regulator of RNA polymerase III [Homo sapiens (human)]

Gene Symbol MAF1
Entrez Gene ID 84232
Full Name MAF1 homolog, negative regulator of RNA polymerase III
Synonyms
General protein information
Preferred Names
repressor of RNA polymerase III transcription MAF1 homolog
Names
repressor of RNA polymerase III transcription MAF1 homolog
homolog of yeast MAF1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8q24.3

Summary This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

610210

Disorder Html:





The following MAF1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAF1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu30790 NM_032272 Homo sapiens MAF1 homolog, negative regulator of RNA polymerase III (MAF1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $199

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu30790
Accession Version NM_032272.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 771bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 16-JUL-2015
Organism Homo sapiens (human)
Product repressor of RNA polymerase III transcription MAF1 homolog
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DN997000.1, BM721318.1, BE093055.1, BC031273.1, BF339064.1 and BC018714.1. On Jul 14, 2006 this sequence version replaced gi:51243066. Summary: This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC018714.1, BC031273.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGAAGCTAT TGGAGAACTC GAGCTTTGAA GCCATCAACT CACAGCTGAC TGTGGAGACT 
GGAGATGCCC ACATCATTGG CAGGATTGAG AGCTACTCAT GTAAGATGGC AGGAGACGAC
AAACACATGT TCAAGCAGTT CTGCCAGGAG GGCCAGCCCC ACGTGCTGGA GGCACTTTCT
CCACCCCAGA CTTCAGGACT GAGCCCCAGC AGACTCAGCA AAAGCCAAGG CGGTGAGGAG
GAGGGCCCCC TCAGTGACAA GTGCAGCCGC AAGACCCTCT TCTACCTGAT TGCCACGCTC
AATGAGTCCT TCAGGCCTGA CTATGACTTC AGCACAGCCC GCAGCCATGA GTTCAGCCGG
GAGCCCAGCC TTAGCTGGGT GGTGAATGCA GTCAACTGCA GTCTGTTCTC AGCTGTGCGG
GAGGACTTCA AGGATCTGAA ACCACAGCTG TGGAACGCGG TGGACGAGGA GATCTGCCTG
GCTGAATGTG ACATCTACAG CTATAACCCA GACTTGGACT CAGATCCCTT CGGGGAGGAT
GGTAGCCTCT GGTCCTTCAA CTACTTCTTC TACAACAAGC GGCTCAAGCG AATCGTCTTC
TTTAGCTGCC GTTCCATCAG TGGCTCCACC TACACACCCT CAGAGGCAGG CAACGAGCTG
GACATGGAGC TGGGGGAGGA GGAGGTGGAG GAAGAAAGCA GAAGCGGGGG CAGTGGGGCC
GAGGAGACCA GCACCATGGA GGAGGACAGG GTCCCAGTGA TCTGTATTTG A
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_115648.2
CDS502..1272
Misc Feature(1)442..444(+)
Misc Feature(2)571..1107(+)
Misc Feature(3)679..681(+)
Misc Feature(4)691..693(+)
Misc Feature(5)694..696(+)
Misc Feature(6)703..705(+)
Misc Feature(7)709..711(+)
Misc Feature(8)724..726(+)
Misc Feature(9)724..726(+)
Misc Feature(10)1135..1137(+)
Misc Feature(11)1141..1143(+)
Exon (1)1..457
Gene:MAF1
Gene Synonym:
Exon (2)458..584
Gene:MAF1
Gene Synonym:
Exon (3)585..713
Gene:MAF1
Gene Synonym:
Exon (4)714..879
Gene:MAF1
Gene Synonym:
Exon (5)880..1001
Gene:MAF1
Gene Synonym:
Exon (6)1002..1121
Gene:MAF1
Gene Synonym:
Exon (7)1122..1250
Gene:MAF1
Gene Synonym:
Exon (8)1251..1775
Gene:MAF1
Gene Synonym:
Translation
Position Chain Variation Link
75 75 a, g dbSNP:550621520
88 88 a, g dbSNP:368359275
90 90 a, c dbSNP:568863338
106 106 a, g dbSNP:537612147
110 110 c, g dbSNP:552537225
122 122 -, tcgc dbSNP:555221400
129 129 a, g dbSNP:570807510
130 130 -, c dbSNP:572312403
180 180 a, g dbSNP:371792980
186 186 a, c dbSNP:753085683
218 218 a, g dbSNP:535014036
229 229 a, g dbSNP:552935234
247 247 a, g dbSNP:570005869
248 248 g, t dbSNP:574460041
269 269 a, g dbSNP:535559043
289 289 c, t dbSNP:535505993
312 312 c, t dbSNP:11546145
387 387 a, g dbSNP:557382381
399 399 c, g dbSNP:575686517
404 404 -, a dbSNP:540931816
405 405 -, c dbSNP:11335429
407 407 -, c dbSNP:398010158
423 423 a, g dbSNP:778417144
447 447 a, c dbSNP:545973264
458 458 a, g, t dbSNP:200240443
461 461 a, g dbSNP:368088636
462 462 c, t dbSNP:148781318
463 463 a, t dbSNP:779040465
468 468 c, t dbSNP:528632290
469 469 c, t dbSNP:546802723
471 471 a, c dbSNP:777628570
473 473 c, t dbSNP:746723710
477 477 a, g dbSNP:770685421
482 482 a, g dbSNP:373954379
483 483 a, g dbSNP:745434380
484 484 a, c dbSNP:769318482
485 485 a, g dbSNP:771239652
491 491 g, t dbSNP:774943933
492 492 c, t dbSNP:368474715
494 494 c, t dbSNP:764455366
495 495 c, t dbSNP:568718279
497 497 a, g dbSNP:762075429
499 499 a, g dbSNP:371970645
510 510 a, g dbSNP:750648890
519 519 c, t dbSNP:376757668
522 522 a, g dbSNP:17852938
526 526 c, t dbSNP:766596518
528 528 c, t dbSNP:753900511
535 535 a, g dbSNP:368525413
540 540 c, t dbSNP:139701481
547 547 c, t dbSNP:774447183
561 561 c, t dbSNP:11136256
576 576 c, t dbSNP:182918416
585 585 a, g dbSNP:750288637
586 586 a, c dbSNP:755875968
594 594 c, t dbSNP:369907286
600 600 a, g dbSNP:753452002
610 610 g, t dbSNP:754615366
615 615 a, g dbSNP:778287529
618 618 c, t dbSNP:747634446
619 619 a, g dbSNP:759030326
621 621 c, t dbSNP:373024962
632 632 a, t dbSNP:747427525
654 654 c, t dbSNP:771446311
660 660 c, g dbSNP:777016306
663 663 c, t dbSNP:144735402
664 664 a, g dbSNP:770003038
682 682 c, t dbSNP:140042949
687 687 c, t dbSNP:763020536
700 700 c, t dbSNP:764984315
701 701 c, t dbSNP:767486499
705 705 c, t dbSNP:773106949
713 713 a, g dbSNP:760553615
718 718 a, c, g dbSNP:200075787
720 720 c, t dbSNP:555628524
725 725 c, g dbSNP:774370156
726 726 c, g dbSNP:760606899
729 729 -, a dbSNP:71516044
732 732 c, t dbSNP:766279310
741 741 a, g dbSNP:776345138
745 745 a, g dbSNP:759369208
754 754 a, g dbSNP:764837171
755 755 a, g dbSNP:375767637
759 759 c, t dbSNP:758085288
775 775 a, t dbSNP:763703723
780 780 c, t dbSNP:751058075
786 786 c, t dbSNP:757765007
787 787 c, t dbSNP:781721737
795 795 c, t dbSNP:750797394
798 798 a, g dbSNP:370144263
803 803 a, g dbSNP:78648437
814 814 a, g dbSNP:573875084
822 822 c, t dbSNP:749540271
842 842 a, g dbSNP:374116632
845 845 a, g dbSNP:778975473
857 857 c, g dbSNP:748211287
860 860 a, g dbSNP:770838568
891 891 a, c dbSNP:774129056
892 892 a, g dbSNP:761327196
894 894 c, t dbSNP:372405558
906 906 c, g dbSNP:749832709
909 909 c, t dbSNP:761255121
911 911 c, t dbSNP:766854897
915 915 c, t dbSNP:544624562
919 919 c, t dbSNP:755303502
920 920 a, g dbSNP:765491765
921 921 a, g dbSNP:376029022
951 951 a, g dbSNP:758483079
953 953 a, g dbSNP:777923769
957 957 c, t dbSNP:747044841
960 960 a, g dbSNP:756185139
965 965 a, g dbSNP:780105616
966 966 c, t dbSNP:145544925
978 978 c, t dbSNP:768590561
979 979 c, t dbSNP:774244100
993 993 c, t dbSNP:747844696
1002 1002 c, t dbSNP:760956377
1008 1008 c, t dbSNP:755026749
1018 1018 g, t dbSNP:778714544
1027 1027 c, t dbSNP:752579869
1032 1032 c, t dbSNP:147311762
1041 1041 c, t dbSNP:777577350
1047 1047 c, t dbSNP:746696579
1050 1050 c, t dbSNP:770504705
1065 1065 -, ctt dbSNP:770705355
1068 1068 c, t dbSNP:780738426
1077 1077 c, g, t dbSNP:376422932
1091 1091 a, g dbSNP:775836372
1095 1095 c, t dbSNP:763465594
1096 1096 a, g dbSNP:768929438
1098 1098 a, c, t dbSNP:141000732
1099 1099 g, t dbSNP:767842852
1104 1104 c, t dbSNP:750601581
1111 1111 c, t dbSNP:760808237
1138 1138 c, t dbSNP:549151505
1146 1146 a, g dbSNP:748822013
1154 1154 a, g dbSNP:567306961
1155 1155 c, g, t dbSNP:538046198
1156 1156 a, g dbSNP:772589555
1161 1161 a, g dbSNP:191280172
1171 1171 c, t dbSNP:747201956
1174 1174 a, g dbSNP:771127212
1182 1182 a, g dbSNP:57433624
1183 1183 a, g dbSNP:759630462
1187 1187 a, t dbSNP:151135525
1189 1189 a, g dbSNP:774292444
1191 1191 a, g dbSNP:761696023
1192 1192 a, g dbSNP:376804374
1199 1199 c, g dbSNP:376042229
1206 1206 c, g, t dbSNP:755776322
1207 1207 a, g dbSNP:11546144
1210 1210 a, g dbSNP:370409437
1213 1213 a, c dbSNP:373891300
1221 1221 a, c, t dbSNP:201941465
1222 1222 a, g dbSNP:748697004
1224 1224 g, t dbSNP:758910975
1231 1231 a, g dbSNP:778296329
1233 1233 c, g dbSNP:747387473
1237 1237 a, g dbSNP:771097973
1245 1245 a, g dbSNP:571800975
1256 1256 c, g dbSNP:550003173
1263 1263 c, g, t dbSNP:746104535
1274 1274 -, gag dbSNP:768016869
1275 1275 a, t dbSNP:780161210
1280 1280 a, g dbSNP:749362476
1284 1284 c, t dbSNP:772041685
1288 1288 a, g dbSNP:369535345
1298 1298 c, t dbSNP:760483411
1314 1314 a, g dbSNP:373113184
1316 1316 a, g dbSNP:201456256
1329 1329 c, t dbSNP:759276773
1332 1332 c, g dbSNP:764969808
1334 1334 a, g dbSNP:752323297
1360 1360 a, g dbSNP:560510445
1377 1377 a, g dbSNP:541297986
1387 1387 a, c, t dbSNP:527694821
1391 1391 a, g dbSNP:781627770
1395 1395 c, t dbSNP:750769711
1404 1404 a, g dbSNP:77842182
1414 1414 c, t dbSNP:774009411
1419 1419 c, t dbSNP:567767009
1425 1425 a, g dbSNP:768748374
1434 1434 c, t dbSNP:778820985
1463 1463 c, t dbSNP:537607571
1481 1481 c, g dbSNP:549979534
1482 1482 c, t dbSNP:571208432
1495 1495 a, g dbSNP:538591281
1500 1500 g, t dbSNP:553661443
1506 1506 c, t dbSNP:187722340
1517 1517 a, g dbSNP:11546143
1525 1525 a, g dbSNP:536267537
1528 1528 a, c dbSNP:200779609
1545 1545 a, c dbSNP:73381311
1560 1560 c, t dbSNP:755695152
1561 1561 a, g dbSNP:576121474
1566 1566 a, g dbSNP:548964574
1584 1584 a, g dbSNP:764592105
1590 1590 c, t dbSNP:146555852
1616 1616 a, g dbSNP:556762710
1622 1622 a, g dbSNP:369586633
1625 1625 g, t dbSNP:774081164
1629 1629 c, t dbSNP:754328218
1632 1632 c, t dbSNP:6685
1647 1647 a, g dbSNP:372815387
1654 1654 g, t dbSNP:545675042
1664 1664 g, t dbSNP:560768540
1671 1671 a, g dbSNP:377586016
1672 1672 a, g dbSNP:377033875
1721 1721 -, tgag dbSNP:750483885
1729 1729 a, g dbSNP:543020466
1733 1733 c, t dbSNP:561208098

Target ORF information:

RefSeq Version NM_032272
Organism Homo sapiens (human)
Definition Homo sapiens MAF1 homolog, negative regulator of RNA polymerase III (MAF1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_032272

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGAAGCTAT TGGAGAACTC GAGCTTTGAA GCCATCAACT CACAGCTGAC TGTGGAGACT 
GGAGATGCCC ACATCATTGG CAGGATTGAG AGCTACTCAT GTAAGATGGC AGGAGACGAC
AAACACATGT TCAAGCAGTT CTGCCAGGAG GGCCAGCCCC ACGTGCTGGA GGCACTTTCT
CCACCCCAGA CTTCAGGACT GAGCCCCAGC AGACTCAGCA AAAGCCAAGG CGGTGAGGAG
GAGGGCCCCC TCAGTGACAA GTGCAGCCGC AAGACCCTCT TCTACCTGAT TGCCACGCTC
AATGAGTCCT TCAGGCCTGA CTATGACTTC AGCACAGCCC GCAGCCATGA GTTCAGCCGG
GAGCCCAGCC TTAGCTGGGT GGTGAATGCA GTCAACTGCA GTCTGTTCTC AGCTGTGCGG
GAGGACTTCA AGGATCTGAA ACCACAGCTG TGGAACGCGG TGGACGAGGA GATCTGCCTG
GCTGAATGTG ACATCTACAG CTATAACCCA GACTTGGACT CAGATCCCTT CGGGGAGGAT
GGTAGCCTCT GGTCCTTCAA CTACTTCTTC TACAACAAGC GGCTCAAGCG AATCGTCTTC
TTTAGCTGCC GTTCCATCAG TGGCTCCACC TACACACCCT CAGAGGCAGG CAACGAGCTG
GACATGGAGC TGGGGGAGGA GGAGGTGGAG GAAGAAAGCA GAAGCGGGGG CAGTGGGGCC
GAGGAGACCA GCACCATGGA GGAGGACAGG GTCCCAGTGA TCTGTATTTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.