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HES7 cDNA ORF clone, Homo sapiens (human)

Gene Symbol HES7
Entrez Gene ID 84667
Full Name hes family bHLH transcription factor 7
Synonyms SCDO4, bHLHb37
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17p13.1

Summary This gene encodes a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]. lac of sum
Disorder MIM:

608059

Disorder Html: Spondylocostal dysostosis 4, autosomal recessive, 613686 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_032580 NP_115969 transcription factor HES-7 isoform 2
XM_011524038 XP_011522340 transcription factor HES-7 isoform X1
XM_011524039 XP_011522341 transcription factor HES-7 isoform X2
XM_011524040 XP_011522342 transcription factor HES-7 isoform X2
XM_011524041 XP_011522343 transcription factor HES-7 isoform X3
XM_011524042 XP_011522344 transcription factor HES-7 isoform X4
NM_001165967 NP_001159439 transcription factor HES-7 isoform 1


Homo sapiens (human) HES7 NP_115969.2
Canis lupus familiaris (dog) HES7 XP_850055.2
Bos taurus (cattle) HES7 NP_001193208.1
Mus musculus (house mouse) Hes7 NP_149030.2
Rattus norvegicus (Norway rat) Hes7 NP_001099262.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100135364 NP_001107508.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following HES7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HES7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu22579 NM_032580 Homo sapiens hes family bHLH transcription factor 7 (HES7), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $188.30
$269.00
OHu73665 XM_011524038 PREDICTED: Homo sapiens hes family bHLH transcription factor 7 (HES7), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $139.30
$199.00
OHu73666 XM_011524039 PREDICTED: Homo sapiens hes family bHLH transcription factor 7 (HES7), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $139.30
$199.00
OHu73666 XM_011524040 PREDICTED: Homo sapiens hes family bHLH transcription factor 7 (HES7), transcript variant X3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $139.30
$199.00
OHu73667 XM_011524041 PREDICTED: Homo sapiens hes family bHLH transcription factor 7 (HES7), transcript variant X4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $139.30
$199.00
OHu73668 XM_011524042 PREDICTED: Homo sapiens hes family bHLH transcription factor 7 (HES7), transcript variant X5, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $139.30
$199.00
OHu22574 NM_001165967 Homo sapiens hes family bHLH transcription factor 7 (HES7), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $188.30
$269.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu22579
Clone ID Related Accession (Same CDS sequence) NM_032580
Accession Version NM_032580.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 678bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 10-MAY-2014
Organism Homo sapiens (human)
Product transcription factor HES-7 isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI259590.1, AB049064.1, AC129492.6 and BC039887.1. This sequence is a reference standard in the RefSeqGene project. On Oct 1, 2009 this sequence version replaced gi:145207993. Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (2) lacks a five amino acid segment, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB049064.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
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481
541
601
661
ATGGTCACCC GGGATCGAGC TGAGAATAGG GACGGCCCCA AGATGCTCAA GCCGCTTGTG 
GAGAAGCGGC GCCGGGACCG CATCAACCGC AGCCTGGAAG AGCTGAGGCT GCTGCTGCTG
GAGCGGACCC GGGACCAGAA CCTCCGGAAC CCGAAGCTGG AGAAAGCGGA GATATTGGAG
TTCGCCGTGG GCTACTTGAG GGAGCGAAGC CGGGTGGAGC CCCCGGGGGT TCCCCGGTCC
CCAGTCCAGG ACGCCGAGGC GCTCGCCAGC TGCTACTTGT CCGGTTTCCG CGAGTGCCTG
CTTCGCTTGG CGGCCTTCGC GCACGACGCC AGCCCGGCCG CCCGCGCCCA GCTCTTCTCC
GCGCTGCACG GCTATCTGCG CCCCAAACCG CCCCGGCCCA AGCCGGTAGA TCCGAGGCCT
CCAGCGCCGC GCCCATCCCT GGACCCCGCC GCACCGGCCC TTGGCCCTGC GCTGCACCAG
CGCCCCCCAG TGCACCAGGG CCACCCTAGC CCGCGCTGCG CATGGTCCCC ATCCCTCTGC
TCCCCGCGCG CCGGGGATTC TGGCGCGCCG GCGCCCCTCA CCGGACTGCT GCCGCCGCCA
CCGCCGCCTC ACAGACAAGA CGGGGCGCCC AAGGCCCCGC TGCCCCCGCC GCCCGCTTTC
TGGAGACCTT GGCCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_115969.2
CDS9..686
Misc Feature(1)48..227(+)
Misc Feature(2)48..173(+)
Misc Feature(3)69..71(+)
Misc Feature(4)87..227(+)
Misc Feature(5)516..518(+)
Misc Feature(6)669..680(+)
Exon (1)1..50
Gene:HES7
Gene Synonym:
Exon (2)51..146
Gene:HES7
Gene Synonym:
Exon (3)147..234
Gene:HES7
Gene Synonym:
Exon (4)235..1667
Gene:HES7
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_032580
Organism Homo sapiens (human)
Definition Homo sapiens hes family bHLH transcription factor 7 (HES7), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_032580

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGTCACCC GGGATCGAGC TGAGAATAGG GACGGCCCCA AGATGCTCAA GCCGCTTGTG 
GAGAAGCGGC GCCGGGACCG CATCAACCGC AGCCTGGAAG AGCTGAGGCT GCTGCTGCTG
GAGCGGACCC GGGACCAGAA CCTCCGGAAC CCGAAGCTGG AGAAAGCGGA GATATTGGAG
TTCGCCGTGG GCTACTTGAG GGAGCGAAGC CGGGTGGAGC CCCCGGGGGT TCCCCGGTCC
CCAGTCCAGG ACGCCGAGGC GCTCGCCAGC TGCTACTTGT CCGGTTTCCG CGAGTGCCTG
CTTCGCTTGG CGGCCTTCGC GCACGACGCC AGCCCGGCCG CCCGCGCCCA GCTCTTCTCC
GCGCTGCACG GCTATCTGCG CCCCAAACCG CCCCGGCCCA AGCCGGTAGA TCCGAGGCCT
CCAGCGCCGC GCCCATCCCT GGACCCCGCC GCACCGGCCC TTGGCCCTGC GCTGCACCAG
CGCCCCCCAG TGCACCAGGG CCACCCTAGC CCGCGCTGCG CATGGTCCCC ATCCCTCTGC
TCCCCGCGCG CCGGGGATTC TGGCGCGCCG GCGCCCCTCA CCGGACTGCT GCCGCCGCCA
CCGCCGCCTC ACAGACAAGA CGGGGCGCCC AAGGCCCCGC TGCCCCCGCC GCCCGCTTTC
TGGAGACCTT GGCCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu73665
Clone ID Related Accession (Same CDS sequence) XM_011524038
Accession Version XM_011524038.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 798bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product transcription factor HES-7 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_010718.17) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGTCGAAGG GGGCGGGGTC GGGTCCTATC CCTCCTACCC TTGGGCCGCG GAATATAAGG 
CTCCAGGCGA GCAGGGAACC GGTCCACACA GGGTCCGGAG GAGCAATGGT CACCCGGGAT
CGAGCTGAGA ATAGGGACGG CCCCAAGATG CTCAAGCCGC TTGTGGAGAA GCGGCGCCGG
GACCGCATCA ACCGCAGCCT GGAAGAGCTG AGGCTGCTGC TGCTGGAGCG GACCCGGGAC
CAGAACCTCC GGAACCCGAA GCTGGAGAAA GCGGAGATAT TGGAGTTCGC CGTGGGCTAC
TTGAGGGAGC GAAGCCGGGT GGAGCCCCCG GCCGCCGCGG CTCCAGGGGT TCCCCGGTCC
CCAGTCCAGG ACGCCGAGGC GCTCGCCAGC TGCTACTTGT CCGGTTTCCG CGAGTGCCTG
CTTCGCTTGG CGGCCTTCGC GCACGACGCC AGCCCGGCCG CCCGCGCCCA GCTCTTCTCC
GCGCTGCACG GCTATCTGCG CCCCAAACCG CCCCGGCCCA AGCCGGTAGA TCCGAGGCCT
CCAGCGCCGC GCCCATCCCT GGACCCCGCC GCACCGGCCC TTGGCCCTGC GCTGCACCAG
CGCCCCCCAG TGCACCAGGG CCACCCTAGC CCGCGCTGCG CATGGTCCCC ATCCCTCTGC
TCCCCGCGCG CCGGGGATTC TGGCGCGCCG GCGCCCCTCA CCGGACTGCT GCCGCCGCCA
CCGCCGCCTC ACAGACAAGA CGGGGCGCCC AAGGCCCCGC TGCCCCCGCC GCCCGCTTTC
TGGAGACCTT GGCCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011522340.1
CDS1071..1868
Misc Feature(1)1215..1394(+)
Misc Feature(2)1215..1340(+)
Misc Feature(3)1236..1238(+)
Misc Feature(4)1254..1394(+)
Translation

Target ORF information:

RefSeq Version XM_011524038
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens hes family bHLH transcription factor 7 (HES7), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011524038

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGTCGAAGG GGGCGGGGTC GGGTCCTATC CCTCCTACCC TTGGGCCGCG GAATATAAGG 
CTCCAGGCGA GCAGGGAACC GGTCCACACA GGGTCCGGAG GAGCAATGGT CACCCGGGAT
CGAGCTGAGA ATAGGGACGG CCCCAAGATG CTCAAGCCGC TTGTGGAGAA GCGGCGCCGG
GACCGCATCA ACCGCAGCCT GGAAGAGCTG AGGCTGCTGC TGCTGGAGCG GACCCGGGAC
CAGAACCTCC GGAACCCGAA GCTGGAGAAA GCGGAGATAT TGGAGTTCGC CGTGGGCTAC
TTGAGGGAGC GAAGCCGGGT GGAGCCCCCG GCCGCCGCGG CTCCAGGGGT TCCCCGGTCC
CCAGTCCAGG ACGCCGAGGC GCTCGCCAGC TGCTACTTGT CCGGTTTCCG CGAGTGCCTG
CTTCGCTTGG CGGCCTTCGC GCACGACGCC AGCCCGGCCG CCCGCGCCCA GCTCTTCTCC
GCGCTGCACG GCTATCTGCG CCCCAAACCG CCCCGGCCCA AGCCGGTAGA TCCGAGGCCT
CCAGCGCCGC GCCCATCCCT GGACCCCGCC GCACCGGCCC TTGGCCCTGC GCTGCACCAG
CGCCCCCCAG TGCACCAGGG CCACCCTAGC CCGCGCTGCG CATGGTCCCC ATCCCTCTGC
TCCCCGCGCG CCGGGGATTC TGGCGCGCCG GCGCCCCTCA CCGGACTGCT GCCGCCGCCA
CCGCCGCCTC ACAGACAAGA CGGGGCGCCC AAGGCCCCGC TGCCCCCGCC GCCCGCTTTC
TGGAGACCTT GGCCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu73666
Clone ID Related Accession (Same CDS sequence) XM_011524039 , XM_011524040
Accession Version XM_011524039.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 789bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product transcription factor HES-7 isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_010718.17) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

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721
781
ATGGGGCCGG CCCTAGGCAA TCTGGGGTCT TGTGGCCGGG GTGGAAGCCG GGCTCTCCCA 
GCGGCGGGAT CCGACGCCGG GGCGGCCGCA CTGAGTCTCG GTCTGGTCGG CCCGCTCTCC
TTTTCTCGCT GGTCGCAGAT GCTCAAGCCG CTTGTGGAGA AGCGGCGCCG GGACCGCATC
AACCGCAGCC TGGAAGAGCT GAGGCTGCTG CTGCTGGAGC GGACCCGGGA CCAGAACCTC
CGGAACCCGA AGCTGGAGAA AGCGGAGATA TTGGAGTTCG CCGTGGGCTA CTTGAGGGAG
CGAAGCCGGG TGGAGCCCCC GGCCGCCGCG GCTCCAGGGG TTCCCCGGTC CCCAGTCCAG
GACGCCGAGG CGCTCGCCAG CTGCTACTTG TCCGGTTTCC GCGAGTGCCT GCTTCGCTTG
GCGGCCTTCG CGCACGACGC CAGCCCGGCC GCCCGCGCCC AGCTCTTCTC CGCGCTGCAC
GGCTATCTGC GCCCCAAACC GCCCCGGCCC AAGCCGGTAG ATCCGAGGCC TCCAGCGCCG
CGCCCATCCC TGGACCCCGC CGCACCGGCC CTTGGCCCTG CGCTGCACCA GCGCCCCCCA
GTGCACCAGG GCCACCCTAG CCCGCGCTGC GCATGGTCCC CATCCCTCTG CTCCCCGCGC
GCCGGGGATT CTGGCGCGCC GGCGCCCCTC ACCGGACTGC TGCCGCCGCC ACCGCCGCCT
CACAGACAAG ACGGGGCGCC CAAGGCCCCG CTGCCCCCGC CGCCCGCTTT CTGGAGACCT
TGGCCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011522341.1
CDS1939..2727
Misc Feature(1)2083..2253(+)
Misc Feature(2)2092..2199(+)
Misc Feature(3)2095..2097(+)
Misc Feature(4)2113..2253(+)
Translation

Target ORF information:

RefSeq Version XM_011524039
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens hes family bHLH transcription factor 7 (HES7), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011524039

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGGGCCGG CCCTAGGCAA TCTGGGGTCT TGTGGCCGGG GTGGAAGCCG GGCTCTCCCA 
GCGGCGGGAT CCGACGCCGG GGCGGCCGCA CTGAGTCTCG GTCTGGTCGG CCCGCTCTCC
TTTTCTCGCT GGTCGCAGAT GCTCAAGCCG CTTGTGGAGA AGCGGCGCCG GGACCGCATC
AACCGCAGCC TGGAAGAGCT GAGGCTGCTG CTGCTGGAGC GGACCCGGGA CCAGAACCTC
CGGAACCCGA AGCTGGAGAA AGCGGAGATA TTGGAGTTCG CCGTGGGCTA CTTGAGGGAG
CGAAGCCGGG TGGAGCCCCC GGCCGCCGCG GCTCCAGGGG TTCCCCGGTC CCCAGTCCAG
GACGCCGAGG CGCTCGCCAG CTGCTACTTG TCCGGTTTCC GCGAGTGCCT GCTTCGCTTG
GCGGCCTTCG CGCACGACGC CAGCCCGGCC GCCCGCGCCC AGCTCTTCTC CGCGCTGCAC
GGCTATCTGC GCCCCAAACC GCCCCGGCCC AAGCCGGTAG ATCCGAGGCC TCCAGCGCCG
CGCCCATCCC TGGACCCCGC CGCACCGGCC CTTGGCCCTG CGCTGCACCA GCGCCCCCCA
GTGCACCAGG GCCACCCTAG CCCGCGCTGC GCATGGTCCC CATCCCTCTG CTCCCCGCGC
GCCGGGGATT CTGGCGCGCC GGCGCCCCTC ACCGGACTGC TGCCGCCGCC ACCGCCGCCT
CACAGACAAG ACGGGGCGCC CAAGGCCCCG CTGCCCCCGC CGCCCGCTTT CTGGAGACCT
TGGCCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu73666
Clone ID Related Accession (Same CDS sequence) XM_011524039 , XM_011524040
Accession Version XM_011524040.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 789bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product transcription factor HES-7 isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_010718.17) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

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61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGGGCCGG CCCTAGGCAA TCTGGGGTCT TGTGGCCGGG GTGGAAGCCG GGCTCTCCCA 
GCGGCGGGAT CCGACGCCGG GGCGGCCGCA CTGAGTCTCG GTCTGGTCGG CCCGCTCTCC
TTTTCTCGCT GGTCGCAGAT GCTCAAGCCG CTTGTGGAGA AGCGGCGCCG GGACCGCATC
AACCGCAGCC TGGAAGAGCT GAGGCTGCTG CTGCTGGAGC GGACCCGGGA CCAGAACCTC
CGGAACCCGA AGCTGGAGAA AGCGGAGATA TTGGAGTTCG CCGTGGGCTA CTTGAGGGAG
CGAAGCCGGG TGGAGCCCCC GGCCGCCGCG GCTCCAGGGG TTCCCCGGTC CCCAGTCCAG
GACGCCGAGG CGCTCGCCAG CTGCTACTTG TCCGGTTTCC GCGAGTGCCT GCTTCGCTTG
GCGGCCTTCG CGCACGACGC CAGCCCGGCC GCCCGCGCCC AGCTCTTCTC CGCGCTGCAC
GGCTATCTGC GCCCCAAACC GCCCCGGCCC AAGCCGGTAG ATCCGAGGCC TCCAGCGCCG
CGCCCATCCC TGGACCCCGC CGCACCGGCC CTTGGCCCTG CGCTGCACCA GCGCCCCCCA
GTGCACCAGG GCCACCCTAG CCCGCGCTGC GCATGGTCCC CATCCCTCTG CTCCCCGCGC
GCCGGGGATT CTGGCGCGCC GGCGCCCCTC ACCGGACTGC TGCCGCCGCC ACCGCCGCCT
CACAGACAAG ACGGGGCGCC CAAGGCCCCG CTGCCCCCGC CGCCCGCTTT CTGGAGACCT
TGGCCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011522342.1
CDS1562..2350
Misc Feature(1)1706..1876(+)
Misc Feature(2)1715..1822(+)
Misc Feature(3)1718..1720(+)
Misc Feature(4)1736..1876(+)
Translation

Target ORF information:

RefSeq Version XM_011524040
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens hes family bHLH transcription factor 7 (HES7), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011524040

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGGGCCGG CCCTAGGCAA TCTGGGGTCT TGTGGCCGGG GTGGAAGCCG GGCTCTCCCA 
GCGGCGGGAT CCGACGCCGG GGCGGCCGCA CTGAGTCTCG GTCTGGTCGG CCCGCTCTCC
TTTTCTCGCT GGTCGCAGAT GCTCAAGCCG CTTGTGGAGA AGCGGCGCCG GGACCGCATC
AACCGCAGCC TGGAAGAGCT GAGGCTGCTG CTGCTGGAGC GGACCCGGGA CCAGAACCTC
CGGAACCCGA AGCTGGAGAA AGCGGAGATA TTGGAGTTCG CCGTGGGCTA CTTGAGGGAG
CGAAGCCGGG TGGAGCCCCC GGCCGCCGCG GCTCCAGGGG TTCCCCGGTC CCCAGTCCAG
GACGCCGAGG CGCTCGCCAG CTGCTACTTG TCCGGTTTCC GCGAGTGCCT GCTTCGCTTG
GCGGCCTTCG CGCACGACGC CAGCCCGGCC GCCCGCGCCC AGCTCTTCTC CGCGCTGCAC
GGCTATCTGC GCCCCAAACC GCCCCGGCCC AAGCCGGTAG ATCCGAGGCC TCCAGCGCCG
CGCCCATCCC TGGACCCCGC CGCACCGGCC CTTGGCCCTG CGCTGCACCA GCGCCCCCCA
GTGCACCAGG GCCACCCTAG CCCGCGCTGC GCATGGTCCC CATCCCTCTG CTCCCCGCGC
GCCGGGGATT CTGGCGCGCC GGCGCCCCTC ACCGGACTGC TGCCGCCGCC ACCGCCGCCT
CACAGACAAG ACGGGGCGCC CAAGGCCCCG CTGCCCCCGC CGCCCGCTTT CTGGAGACCT
TGGCCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu73667
Clone ID Related Accession (Same CDS sequence) XM_011524041
Accession Version XM_011524041.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 780bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product transcription factor HES-7 isoform X3
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_010718.17) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGCCAGGG GCGGCCCCAC ACCCGGGTGC GAACAGCCGG GGGCCCCCAG CCTCGCGTGC 
AGACACTTTG TCCTGAAGCC CTCGAGTGGT CAGGCATCGT TCTGCGGAGG GTCATGCTCT
TGGTTTGAGA TGCTCAAGCC GCTTGTGGAG AAGCGGCGCC GGGACCGCAT CAACCGCAGC
CTGGAAGAGC TGAGGCTGCT GCTGCTGGAG CGGACCCGGG ACCAGAACCT CCGGAACCCG
AAGCTGGAGA AAGCGGAGAT ATTGGAGTTC GCCGTGGGCT ACTTGAGGGA GCGAAGCCGG
GTGGAGCCCC CGGCCGCCGC GGCTCCAGGG GTTCCCCGGT CCCCAGTCCA GGACGCCGAG
GCGCTCGCCA GCTGCTACTT GTCCGGTTTC CGCGAGTGCC TGCTTCGCTT GGCGGCCTTC
GCGCACGACG CCAGCCCGGC CGCCCGCGCC CAGCTCTTCT CCGCGCTGCA CGGCTATCTG
CGCCCCAAAC CGCCCCGGCC CAAGCCGGTA GATCCGAGGC CTCCAGCGCC GCGCCCATCC
CTGGACCCCG CCGCACCGGC CCTTGGCCCT GCGCTGCACC AGCGCCCCCC AGTGCACCAG
GGCCACCCTA GCCCGCGCTG CGCATGGTCC CCATCCCTCT GCTCCCCGCG CGCCGGGGAT
TCTGGCGCGC CGGCGCCCCT CACCGGACTG CTGCCGCCGC CACCGCCGCC TCACAGACAA
GACGGGGCGC CCAAGGCCCC GCTGCCCCCG CCGCCCGCTT TCTGGAGACC TTGGCCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011522343.1
CDS167..946
Misc Feature(1)302..472(+)
Misc Feature(2)311..418(+)
Misc Feature(3)314..316(+)
Misc Feature(4)332..472(+)
Translation

Target ORF information:

RefSeq Version XM_011524041
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens hes family bHLH transcription factor 7 (HES7), transcript variant X4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011524041

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGCCAGGG GCGGCCCCAC ACCCGGGTGC GAACAGCCGG GGGCCCCCAG CCTCGCGTGC 
AGACACTTTG TCCTGAAGCC CTCGAGTGGT CAGGCATCGT TCTGCGGAGG GTCATGCTCT
TGGTTTGAGA TGCTCAAGCC GCTTGTGGAG AAGCGGCGCC GGGACCGCAT CAACCGCAGC
CTGGAAGAGC TGAGGCTGCT GCTGCTGGAG CGGACCCGGG ACCAGAACCT CCGGAACCCG
AAGCTGGAGA AAGCGGAGAT ATTGGAGTTC GCCGTGGGCT ACTTGAGGGA GCGAAGCCGG
GTGGAGCCCC CGGCCGCCGC GGCTCCAGGG GTTCCCCGGT CCCCAGTCCA GGACGCCGAG
GCGCTCGCCA GCTGCTACTT GTCCGGTTTC CGCGAGTGCC TGCTTCGCTT GGCGGCCTTC
GCGCACGACG CCAGCCCGGC CGCCCGCGCC CAGCTCTTCT CCGCGCTGCA CGGCTATCTG
CGCCCCAAAC CGCCCCGGCC CAAGCCGGTA GATCCGAGGC CTCCAGCGCC GCGCCCATCC
CTGGACCCCG CCGCACCGGC CCTTGGCCCT GCGCTGCACC AGCGCCCCCC AGTGCACCAG
GGCCACCCTA GCCCGCGCTG CGCATGGTCC CCATCCCTCT GCTCCCCGCG CGCCGGGGAT
TCTGGCGCGC CGGCGCCCCT CACCGGACTG CTGCCGCCGC CACCGCCGCC TCACAGACAA
GACGGGGCGC CCAAGGCCCC GCTGCCCCCG CCGCCCGCTT TCTGGAGACC TTGGCCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu73668
Clone ID Related Accession (Same CDS sequence) XM_011524042
Accession Version XM_011524042.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 651bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product transcription factor HES-7 isoform X4
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_010718.17) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
ATGCTCAAGC CGCTTGTGGA GAAGCGGCGC CGGGACCGCA TCAACCGCAG CCTGGAAGAG 
CTGAGGCTGC TGCTGCTGGA GCGGACCCGG GACCAGAACC TCCGGAACCC GAAGCTGGAG
AAAGCGGAGA TATTGGAGTT CGCCGTGGGC TACTTGAGGG AGCGAAGCCG GGTGGAGCCC
CCGGCCGCCG CGGCTCCAGG GGTTCCCCGG TCCCCAGTCC AGGACGCCGA GGCGCTCGCC
AGCTGCTACT TGTCCGGTTT CCGCGAGTGC CTGCTTCGCT TGGCGGCCTT CGCGCACGAC
GCCAGCCCGG CCGCCCGCGC CCAGCTCTTC TCCGCGCTGC ACGGCTATCT GCGCCCCAAA
CCGCCCCGGC CCAAGCCGGT AGATCCGAGG CCTCCAGCGC CGCGCCCATC CCTGGACCCC
GCCGCACCGG CCCTTGGCCC TGCGCTGCAC CAGCGCCCCC CAGTGCACCA GGGCCACCCT
AGCCCGCGCT GCGCATGGTC CCCATCCCTC TGCTCCCCGC GCGCCGGGGA TTCTGGCGCG
CCGGCGCCCC TCACCGGACT GCTGCCGCCG CCACCGCCGC CTCACAGACA AGACGGGGCG
CCCAAGGCCC CGCTGCCCCC GCCGCCCGCT TTCTGGAGAC CTTGGCCCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011522344.1
CDS508..1158
Misc Feature(1)514..684(+)
Misc Feature(2)523..630(+)
Misc Feature(3)526..528(+)
Misc Feature(4)544..684(+)
Translation

Target ORF information:

RefSeq Version XM_011524042
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens hes family bHLH transcription factor 7 (HES7), transcript variant X5, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011524042

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGCTCAAGC CGCTTGTGGA GAAGCGGCGC CGGGACCGCA TCAACCGCAG CCTGGAAGAG 
CTGAGGCTGC TGCTGCTGGA GCGGACCCGG GACCAGAACC TCCGGAACCC GAAGCTGGAG
AAAGCGGAGA TATTGGAGTT CGCCGTGGGC TACTTGAGGG AGCGAAGCCG GGTGGAGCCC
CCGGCCGCCG CGGCTCCAGG GGTTCCCCGG TCCCCAGTCC AGGACGCCGA GGCGCTCGCC
AGCTGCTACT TGTCCGGTTT CCGCGAGTGC CTGCTTCGCT TGGCGGCCTT CGCGCACGAC
GCCAGCCCGG CCGCCCGCGC CCAGCTCTTC TCCGCGCTGC ACGGCTATCT GCGCCCCAAA
CCGCCCCGGC CCAAGCCGGT AGATCCGAGG CCTCCAGCGC CGCGCCCATC CCTGGACCCC
GCCGCACCGG CCCTTGGCCC TGCGCTGCAC CAGCGCCCCC CAGTGCACCA GGGCCACCCT
AGCCCGCGCT GCGCATGGTC CCCATCCCTC TGCTCCCCGC GCGCCGGGGA TTCTGGCGCG
CCGGCGCCCC TCACCGGACT GCTGCCGCCG CCACCGCCGC CTCACAGACA AGACGGGGCG
CCCAAGGCCC CGCTGCCCCC GCCGCCCGCT TTCTGGAGAC CTTGGCCCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu22574
Clone ID Related Accession (Same CDS sequence) NM_001165967
Accession Version NM_001165967.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 693bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product transcription factor HES-7 isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI259590.1, BC039887.1 and AC129492.6. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC039887.1, BI335370.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968832 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
ATGGTCACCC GGGATCGAGC TGAGAATAGG GACGGCCCCA AGATGCTCAA GCCGCTTGTG 
GAGAAGCGGC GCCGGGACCG CATCAACCGC AGCCTGGAAG AGCTGAGGCT GCTGCTGCTG
GAGCGGACCC GGGACCAGAA CCTCCGGAAC CCGAAGCTGG AGAAAGCGGA GATATTGGAG
TTCGCCGTGG GCTACTTGAG GGAGCGAAGC CGGGTGGAGC CCCCGGCCGC CGCGGCTCCA
GGGGTTCCCC GGTCCCCAGT CCAGGACGCC GAGGCGCTCG CCAGCTGCTA CTTGTCCGGT
TTCCGCGAGT GCCTGCTTCG CTTGGCGGCC TTCGCGCACG ACGCCAGCCC GGCCGCCCGC
GCCCAGCTCT TCTCCGCGCT GCACGGCTAT CTGCGCCCCA AACCGCCCCG GCCCAAGCCG
GTAGATCCGA GGCCTCCAGC GCCGCGCCCA TCCCTGGACC CCGCCGCACC GGCCCTTGGC
CCTGCGCTGC ACCAGCGCCC CCCAGTGCAC CAGGGCCACC CTAGCCCGCG CTGCGCATGG
TCCCCATCCC TCTGCTCCCC GCGCGCCGGG GATTCTGGCG CGCCGGCGCC CCTCACCGGA
CTGCTGCCGC CGCCACCGCC GCCTCACAGA CAAGACGGGG CGCCCAAGGC CCCGCTGCCC
CCGCCGCCCG CTTTCTGGAG ACCTTGGCCC TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001159439.1
CDS9..701
Misc Feature(1)48..227(+)
Misc Feature(2)48..173(+)
Misc Feature(3)69..71(+)
Misc Feature(4)87..227(+)
Exon (1)1..50
Gene:HES7
Gene Synonym:
Exon (2)51..146
Gene:HES7
Gene Synonym:
Exon (3)147..234
Gene:HES7
Gene Synonym:
Exon (4)235..1682
Gene:HES7
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001165967
Organism Homo sapiens (human)
Definition Homo sapiens hes family bHLH transcription factor 7 (HES7), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001165967

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGTCACCC GGGATCGAGC TGAGAATAGG GACGGCCCCA AGATGCTCAA GCCGCTTGTG 
GAGAAGCGGC GCCGGGACCG CATCAACCGC AGCCTGGAAG AGCTGAGGCT GCTGCTGCTG
GAGCGGACCC GGGACCAGAA CCTCCGGAAC CCGAAGCTGG AGAAAGCGGA GATATTGGAG
TTCGCCGTGG GCTACTTGAG GGAGCGAAGC CGGGTGGAGC CCCCGGCCGC CGCGGCTCCA
GGGGTTCCCC GGTCCCCAGT CCAGGACGCC GAGGCGCTCG CCAGCTGCTA CTTGTCCGGT
TTCCGCGAGT GCCTGCTTCG CTTGGCGGCC TTCGCGCACG ACGCCAGCCC GGCCGCCCGC
GCCCAGCTCT TCTCCGCGCT GCACGGCTAT CTGCGCCCCA AACCGCCCCG GCCCAAGCCG
GTAGATCCGA GGCCTCCAGC GCCGCGCCCA TCCCTGGACC CCGCCGCACC GGCCCTTGGC
CCTGCGCTGC ACCAGCGCCC CCCAGTGCAC CAGGGCCACC CTAGCCCGCG CTGCGCATGG
TCCCCATCCC TCTGCTCCCC GCGCGCCGGG GATTCTGGCG CGCCGGCGCC CCTCACCGGA
CTGCTGCCGC CGCCACCGCC GCCTCACAGA CAAGACGGGG CGCCCAAGGC CCCGCTGCCC
CCGCCGCCCG CTTTCTGGAG ACCTTGGCCC TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Mutation of HES7 in a large extended family with spondylocostal dysostosis and dextrocardia with situs inversus
Am. J. Med. Genet. A 161 (9), 2244-2249 (2013)
Sparrow DB, Faqeih EA, Sallout B, Alswaid A, Ababneh F, Al-Sayed M, Rukban H, Eyaid WM, Kageyama R, Ellard S, Turnpenny PD and Dunwoodie SL.


book

Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis
Stud Health Technol Inform 176, 52-55 (2012)
Qiu XS, Zhou S, Jiang H, Ji ML, Ding Q, Lv F, Liu Z, Tang N, Cheng JC and Qiu Y.


book

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study
Diabetes Care 33 (10), 2250-2253 (2010)
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC and Anand S.


book

Polymorphisms in innate immunity genes and risk of childhood leukemia
Hum. Immunol. 71 (7), 727-730 (2010)
Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N and Kang D.


book

Risk of meningioma and common variation in genes related to innate immunity
Cancer Epidemiol. Biomarkers Prev. 19 (5), 1356-1361 (2010)
Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ and Inskip PD.


book

Common variation in genes related to innate immunity and risk of adult glioma
Cancer Epidemiol. Biomarkers Prev. 18 (5), 1651-1658 (2009)
Rajaraman P, Brenner AV, Butler MA, Wang SS, Pfeiffer RM, Ruder AM, Linet MS, Yeager M, Wang Z, Orr N, Fine HA, Kwon D, Thomas G, Rothman N, Inskip PD and Chanock SJ.


book

Mutation of Hairy-and-Enhancer-of-Split-7 in humans causes spondylocostal dysostosis
Hum. Mol. Genet. 17 (23), 3761-3766 (2008)
Sparrow DB, Guillen-Navarro E, Fatkin D and Dunwoodie SL.


book

Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer
Int. J. Oncol. 31 (2), 461-466 (2007)
Katoh M and Katoh M.


book

Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm
Genes Cells 6 (2), 175-185 (2001)
Bessho Y, Miyoshi G, Sakata R and Kageyama R.


book

Spondylocostal Dysostosis, Autosomal Recessive
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Turnpenny,P.D., Young,E. and (International Consortium for Vertebral Anomalies and Scoliosis),I.C.V.A.S.


 
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