||ORF Nucleotide Sequence (Length: 1584bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK291585.1, AL035079.14 and
This sequence is a reference standard in the RefSeqGene project.
On Oct 3, 2009 this sequence version replaced gi:60302919.
Summary: This gene encodes catalase, a key antioxidant enzyme in
the bodies defense against oxidative stress. Catalase is a heme
enzyme that is present in the peroxisome of nearly all aerobic
cells. Catalase converts the reactive oxygen species hydrogen
peroxide to water and oxygen and thereby mitigates the toxic
effects of hydrogen peroxide. Oxidative stress is hypothesized to
play a role in the development of many chronic or late-onset
diseases such as diabetes, asthma, Alzheimer's disease, systemic
lupus erythematosus, rheumatoid arthritis, and cancers.
Polymorphisms in this gene have been associated with decreases in
catalase activity but, to date, acatalasemia is the only disease
known to be caused by this gene. [provided by RefSeq, Oct 2009].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: AK291585.1, X04076.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.