×

TCAP cDNA ORF clone, Homo sapiens (human)

Gene Symbol TCAP
Entrez Gene ID 8557
Full Name titin-cap
Synonyms CMD1N, CMH25, LGMD2G, T-cap, TELE, telethonin
General protein information
Preferred Names
telethonin
Names
telethonin
titin cap protein
19 kDa sarcomeric protein
limb girdle muscular dystrophy 2G (autosomal recessive)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q12

Summary Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

604488

Disorder Html: Muscular dystrophy, limb-girdle, type 2G, 601954 (3);





The following TCAP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TCAP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu18837 NM_003673 Homo sapiens titin-cap (TCAP), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$69.30
$99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu18837
Accession Version NM_003673.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 504bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product telethonin
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA899335.1 and AJ000491.1. This sequence is a reference standard in the RefSeqGene project. On Oct 21, 2008 this sequence version replaced gi:19924299. Summary: Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ000491.1, BC012628.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
ATGGCTACCT CAGAGCTGAG CTGCGAGGTG TCGGAGGAGA ACTGTGAGCG CCGGGAGGCC 
TTCTGGGCAG AATGGAAGGA TCTGACACTG TCCACACGGC CCGAGGAGGG CTGCTCCCTG
CATGAGGAGG ACACCCAGAG ACATGAGACC TACCACCAGC AGGGGCAGTG CCAGGTGCTG
GTGCAGCGCT CGCCCTGGCT GATGATGCGG ATGGGCATCC TCGGCCGTGG GCTGCAGGAG
TACCAGCTGC CCTACCAGCG GGTACTGCCG CTGCCCATCT TCACCCCTGC CAAGATGGGC
GCCACCAAGG AGGAGCGTGA GGACACCCCC ATCCAGCTTC AGGAGCTGCT GGCGCTGGAG
ACAGCCCTGG GTGGCCAGTG TGTGGACCGC CAGGAGGTGG CTGAGATCAC AAAGCAGCTG
CCCCCTGTGG TGCCTGTCAG CAAGCCCGGT GCACTTCGTC GCTCCCTGTC CCGCTCCATG
TCCCAGGAAG CACAGAGAGG CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_003664.1
CDS15..518
Misc Feature(1)3..5(+)
Misc Feature(2)15..515(+)
Misc Feature(3)483..485(+)
Misc Feature(4)483..485(+)
Exon (1)1..124
Gene:TCAP
Gene Synonym:
Exon (2)125..963
Gene:TCAP
Gene Synonym:
Translation
Position Chain Variation Link
2 2 a, g dbSNP:368175926
3 3 a, g, t dbSNP:77831798
19 19 c, t dbSNP:769455424
22 22 a, c dbSNP:775080606
26 26 -, ag dbSNP:757082868
30 30 a, c dbSNP:201664428
37 37 -, cgaggtgt dbSNP:778568339
38 38 c, t dbSNP:756548785
46 46 a, c, g, t dbSNP:45495192
47 47 -, gga dbSNP:537595753
47 47 a, g dbSNP:762224660
51 51 -, gag dbSNP:397516862
57 57 -, tg dbSNP:758142728
57 57 a, c, t dbSNP:764350236
64 64 a, c, g dbSNP:750796201
67 67 a, g dbSNP:45614536
68 68 c, g dbSNP:754054712
74 74 c, g dbSNP:146502276
80 80 a, g dbSNP:141019458
89 89 a, g dbSNP:778851652
96 96 c, t dbSNP:747005525
99 99 a, t dbSNP:757117448
101 101 a, c, g dbSNP:144741021
111 111 c, t dbSNP:145524909
117 117 a, g dbSNP:779699520
122 122 a, g dbSNP:748882218
123 123 -, gg dbSNP:786205076
127 127 a, g, t dbSNP:375310569
131 131 c, t dbSNP:759893644
146 146 c, t dbSNP:397516861
153 153 a, c dbSNP:752894436
157 157 a, g dbSNP:763037167
159 159 a, g dbSNP:45513698
160 160 a, g dbSNP:773342153
165 165 c, t dbSNP:750429579
166 166 a, t dbSNP:756017005
167 167 a, c dbSNP:779949893
168 168 c, g dbSNP:753599743
171 171 c, t dbSNP:104894655
184 184 a, g dbSNP:754762491
185 185 a, c, g dbSNP:369447207
192 192 c, t dbSNP:549769566
201 201 c, t dbSNP:758048577
202 202 a, g dbSNP:777384494
205 205 c, t dbSNP:45458802
206 206 a, g dbSNP:771585295
209 209 c, g dbSNP:370118201
212 212 c, g dbSNP:777153450
213 213 c, t dbSNP:746219012
216 216 a, t dbSNP:770133993
222 222 c, t dbSNP:775636212
223 223 a, g dbSNP:552865793
225 225 a, g dbSNP:764200782
226 226 c, t dbSNP:143465226
232 232 c, t dbSNP:761833243
235 235 a, t dbSNP:17851031
236 236 c, t dbSNP:766260041
237 237 a, g dbSNP:753744791
239 239 c, t dbSNP:754744780
240 240 c, t dbSNP:572836774
241 241 a, g dbSNP:752435787
254 254 g, t dbSNP:758101613
273 273 c, t dbSNP:777518512
274 274 a, g dbSNP:121434298
275 275 g, t dbSNP:375389509
276 276 g, t dbSNP:756715463
278 278 a, t dbSNP:781560443
283 283 c, t dbSNP:727504427
284 284 a, g dbSNP:372538567
290 290 a, c, t dbSNP:147979713
291 291 a, c dbSNP:76130885
293 293 c, t dbSNP:144149447
296 296 c, t dbSNP:749565002
299 299 c, t dbSNP:768889521
304 304 c, t dbSNP:774516749
308 308 a, g dbSNP:761888264
309 309 a, g dbSNP:767577344
314 314 a, c, t dbSNP:187261074
315 315 a, g dbSNP:727503455
322 322 -, agg dbSNP:748506107
327 327 a, c, g dbSNP:146906267
330 330 a, c, t dbSNP:45578741
331 331 a, g dbSNP:576098128
337 337 a, g dbSNP:751842310
339 339 a, g dbSNP:780752425
345 345 -, t dbSNP:770194856
351 351 c, t dbSNP:372312912
367 367 c, t dbSNP:143233087
391 391 a, g dbSNP:558480997
392 392 c, g dbSNP:749685550
401 401 c, g dbSNP:768942598
402 402 a, c, t dbSNP:374886575
403 403 a, g dbSNP:147503632
408 408 a, g dbSNP:748358368
415 415 a, c dbSNP:786205287
416 416 g, t dbSNP:772083153
424 424 a, c, t dbSNP:773317399
435 435 c, g dbSNP:45509691
450 450 g, t dbSNP:769800632
461 461 c, t dbSNP:45614332
462 462 a, g dbSNP:762850913
466 466 c, t dbSNP:763965899
467 467 a, c dbSNP:1053651
471 471 a, c, t dbSNP:761498487
472 472 a, g dbSNP:149585781
474 474 c, t dbSNP:755539784
475 475 a, g dbSNP:780544264
486 486 a, c dbSNP:397516863
487 487 a, g dbSNP:397516864
494 494 a, g dbSNP:755395354
507 507 c, g dbSNP:397516865
511 511 a, g dbSNP:779217085
521 521 a, g dbSNP:748365337
534 534 a, g dbSNP:45495400
540 540 c, t dbSNP:200333339
547 547 -, c dbSNP:759564316
548 548 a, c dbSNP:777817968
550 550 a, g dbSNP:375843419
551 551 c, t dbSNP:771072422
552 552 c, g dbSNP:775624321
569 569 c, g dbSNP:762976588
572 572 a, g dbSNP:45592941
594 594 g, t dbSNP:45506294
717 717 g, t dbSNP:45503594
729 729 -, g dbSNP:779158527
810 810 a, g dbSNP:185210946
815 815 c, t dbSNP:772638575
823 823 a, g dbSNP:45521334
838 838 a, g dbSNP:571366329
846 846 a, c dbSNP:532000115
863 863 a, c dbSNP:372376824
876 876 a, g dbSNP:188530675
895 895 a, c, g dbSNP:3194794
913 913 c, t dbSNP:45540732
916 916 c, t dbSNP:554308696
926 926 c, t dbSNP:569522916
936 936 c, t dbSNP:45500896
937 937 a, g, t dbSNP:558774503
943 943 a, g dbSNP:577303207
954 954 -, at dbSNP:45459794

Target ORF information:

RefSeq Version NM_003673
Organism Homo sapiens (human)
Definition Homo sapiens titin-cap (TCAP), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003673

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGCTACCT CAGAGCTGAG CTGCGAGGTG TCGGAGGAGA ACTGTGAGCG CCGGGAGGCC 
TTCTGGGCAG AATGGAAGGA TCTGACACTG TCCACACGGC CCGAGGAGGG CTGCTCCCTG
CATGAGGAGG ACACCCAGAG ACATGAGACC TACCACCAGC AGGGGCAGTG CCAGGTGCTG
GTGCAGCGCT CGCCCTGGCT GATGATGCGG ATGGGCATCC TCGGCCGTGG GCTGCAGGAG
TACCAGCTGC CCTACCAGCG GGTACTGCCG CTGCCCATCT TCACCCCTGC CAAGATGGGC
GCCACCAAGG AGGAGCGTGA GGACACCCCC ATCCAGCTTC AGGAGCTGCT GGCGCTGGAG
ACAGCCCTGG GTGGCCAGTG TGTGGACCGC CAGGAGGTGG CTGAGATCAC AAAGCAGCTG
CCCCCTGTGG TGCCTGTCAG CAAGCCCGGT GCACTTCGTC GCTCCCTGTC CCGCTCCATG
TCCCAGGAAG CACAGAGAGG CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
*
*
*
*