×

CAV3 cDNA ORF clone, Homo sapiens (human)

Gene Symbol CAV3
Entrez Gene ID 859
Full Name caveolin 3
Synonyms LGMD1C, LQT9, VIP-21, VIP21
General protein information
Preferred Names
caveolin-3
Names
caveolin-3
M-caveolin
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3p25

Summary This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

601253

Disorder Html: Muscular dystrophy, limb-girdle, type IC, 607801 (3); Rippling

mRNA and Protein(s)

mRNA Protein Name
NM_033337 NP_203123 caveolin-3
NM_001234 NP_001225 caveolin-3



Homo sapiens (human) CAV3 NP_203123.1
Pan troglodytes (chimpanzee) CAV3 XP_001144093.2
Macaca mulatta (Rhesus monkey) CAV3 XP_001097615.1
Canis lupus familiaris (dog) CAV3 XP_541786.2
Bos taurus (cattle) CAV3 NP_001040023.1
Mus musculus (house mouse) Cav3 NP_031643.1
Rattus norvegicus (Norway rat) Cav3 NP_062028.1
Gallus gallus (chicken) CAV3 NP_989701.1
Danio rerio (zebrafish) cav3 NP_991301.1
Xenopus (Silurana) tropicalis (western clawed frog) cav3.1 NP_001096498.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CAV3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CAV3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu21738
NM_033337 Homo sapiens caveolin 3 (CAV3), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu21738
NM_001234 Homo sapiens caveolin 3 (CAV3), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu21738
Clone ID Related Accession (Same CDS sequence) NM_001234 , NM_033337
Accession Version NM_033337.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 456bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product caveolin-3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK291892.1, BC102033.1, BX114193.1 and AA993189.1. This sequence is a reference standard in the RefSeqGene project. On Jun 23, 2010 this sequence version replaced gi:15451859. Transcript Variant: This variant (1) is longer than variant 2, since it includes a differentially spliced intron located in the 3' UTR, but both transcripts encode identical proteins. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA897474.1, AF043101.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2146236 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
ATGATGGCAG AAGAGCACAC AGATCTCGAG GCCCAGATCG TCAAGGATAT CCACTGCAAG 
GAGATTGACC TGGTGAACCG AGACCCCAAG AACATTAACG AGGACATAGT CAAGGTGGAT
TTTGAAGACG TGATCGCAGA GCCTGTGGGC ACCTACAGCT TTGACGGCGT GTGGAAGGTG
AGCTACACCA CCTTCACTGT CTCCAAGTAC TGGTGCTACC GTCTGTTGTC CACGCTGCTG
GGCGTCCCAC TGGCCCTGCT CTGGGGCTTC CTGTTCGCCT GCATCTCCTT CTGCCACATC
TGGGCGGTGG TGCCATGCAT TAAGAGCTAC CTGATCGAGA TCCAGTGCAT CAGCCACATC
TACTCACTCT GCATCCGCAC CTTCTGCAAC CCACTCTTCG CGGCCCTGGG CCAGGTCTGC
AGCAGCATCA AGGTGGTGCT GCGGAAGGAG GTCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_203123.1
CDS78..533
Misc Feature(1)81..527(+)
Misc Feature(2)267..419(+)
Exon (1)1..191
Gene:CAV3
Gene Synonym:
Exon (2)192..1431
Gene:CAV3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_033337
Organism Homo sapiens (human)
Definition Homo sapiens caveolin 3 (CAV3), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_033337

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGATGGCAG AAGAGCACAC AGATCTCGAG GCCCAGATCG TCAAGGATAT CCACTGCAAG 
GAGATTGACC TGGTGAACCG AGACCCCAAG AACATTAACG AGGACATAGT CAAGGTGGAT
TTTGAAGACG TGATCGCAGA GCCTGTGGGC ACCTACAGCT TTGACGGCGT GTGGAAGGTG
AGCTACACCA CCTTCACTGT CTCCAAGTAC TGGTGCTACC GTCTGTTGTC CACGCTGCTG
GGCGTCCCAC TGGCCCTGCT CTGGGGCTTC CTGTTCGCCT GCATCTCCTT CTGCCACATC
TGGGCGGTGG TGCCATGCAT TAAGAGCTAC CTGATCGAGA TCCAGTGCAT CAGCCACATC
TACTCACTCT GCATCCGCAC CTTCTGCAAC CCACTCTTCG CGGCCCTGGG CCAGGTCTGC
AGCAGCATCA AGGTGGTGCT GCGGAAGGAG GTCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu21738
Clone ID Related Accession (Same CDS sequence) NM_001234 , NM_033337
Accession Version NM_001234.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 456bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product caveolin-3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK291892.1, Y14747.1, AC068312.5 and AA993189.1. On Nov 9, 2011 this sequence version replaced gi:15451858. Transcript Variant: This variant (2) is shorter than variant 1, since it lacks a differentially spliced intron located in the 3' UTR, but both transcripts encode identical proteins. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y14747.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149178, SAMEA2154361 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
ATGATGGCAG AAGAGCACAC AGATCTCGAG GCCCAGATCG TCAAGGATAT CCACTGCAAG 
GAGATTGACC TGGTGAACCG AGACCCCAAG AACATTAACG AGGACATAGT CAAGGTGGAT
TTTGAAGACG TGATCGCAGA GCCTGTGGGC ACCTACAGCT TTGACGGCGT GTGGAAGGTG
AGCTACACCA CCTTCACTGT CTCCAAGTAC TGGTGCTACC GTCTGTTGTC CACGCTGCTG
GGCGTCCCAC TGGCCCTGCT CTGGGGCTTC CTGTTCGCCT GCATCTCCTT CTGCCACATC
TGGGCGGTGG TGCCATGCAT TAAGAGCTAC CTGATCGAGA TCCAGTGCAT CAGCCACATC
TACTCACTCT GCATCCGCAC CTTCTGCAAC CCACTCTTCG CGGCCCTGGG CCAGGTCTGC
AGCAGCATCA AGGTGGTGCT GCGGAAGGAG GTCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001225.1
CDS78..533
Misc Feature(1)81..527(+)
Misc Feature(2)267..419(+)
Exon (1)1..191
Gene:CAV3
Gene Synonym:
Exon (2)192..539
Gene:CAV3
Gene Synonym:
Exon (3)540..1335
Gene:CAV3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001234
Organism Homo sapiens (human)
Definition Homo sapiens caveolin 3 (CAV3), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001234

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGATGGCAG AAGAGCACAC AGATCTCGAG GCCCAGATCG TCAAGGATAT CCACTGCAAG 
GAGATTGACC TGGTGAACCG AGACCCCAAG AACATTAACG AGGACATAGT CAAGGTGGAT
TTTGAAGACG TGATCGCAGA GCCTGTGGGC ACCTACAGCT TTGACGGCGT GTGGAAGGTG
AGCTACACCA CCTTCACTGT CTCCAAGTAC TGGTGCTACC GTCTGTTGTC CACGCTGCTG
GGCGTCCCAC TGGCCCTGCT CTGGGGCTTC CTGTTCGCCT GCATCTCCTT CTGCCACATC
TGGGCGGTGG TGCCATGCAT TAAGAGCTAC CTGATCGAGA TCCAGTGCAT CAGCCACATC
TACTCACTCT GCATCCGCAC CTTCTGCAAC CCACTCTTCG CGGCCCTGGG CCAGGTCTGC
AGCAGCATCA AGGTGGTGCT GCGGAAGGAG GTCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

The role of CAV3 in long-QT syndrome: clinical and functional assessment of a caveolin-3/Kv11.1 double heterozygote versus caveolin-3 single heterozygote
Circ Cardiovasc Genet 6 (5), 452-461 (2013)
Hedley PL, Kanters JK, Dembic M, Jespersen T, Skibsbye L, Aidt FH, Eschen O, Graff C, Behr ER, Schlamowitz S, Corfield V, McKenna WJ and Christiansen M.


book

Mutations in genes encoding cardiac ion channels previously associated with sudden infant death syndrome (SIDS) are present with high frequency in new exome data
Can J Cardiol 29 (9), 1104-1109 (2013)
Andreasen C, Refsgaard L, Nielsen JB, Sajadieh A, Winkel BG, Tfelt-Hansen J, Haunso S, Holst AG, Svendsen JH and Olesen MS.


book

Caveolin-3 suppresses late sodium current by inhibiting nNOS-dependent S-nitrosylation of SCN5A
J. Mol. Cell. Cardiol. 61, 102-110 (2013)
Cheng J, Valdivia CR, Vaidyanathan R, Balijepalli RC, Ackerman MJ and Makielski JC.


book

The interaction of caveolin 3 protein with the potassium inward rectifier channel Kir2.1: physiology and pathology related to long qt syndrome 9 (LQT9)
J. Biol. Chem. 288 (24), 17472-17480 (2013)
Vaidyanathan R, Vega AL, Song C, Zhou Q, Tan BH, Berger S, Makielski JC and Eckhardt LL.


book

Interaction of neuronal nitric-oxide synthase with caveolin-3 in skeletal muscle. Identification of a novel caveolin scaffolding/inhibitory domain
J. Biol. Chem. 272 (45), 28187-28190 (1997)
Venema VJ, Ju H, Zou R and Venema RC.


book

Association of phosphofructokinase-M with caveolin-3 in differentiated skeletal myotubes. Dynamic regulation by extracellular glucose and intracellular metabolites
J. Biol. Chem. 272 (33), 20698-20705 (1997)
Scherer PE and Lisanti MP.


book

Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle
J. Biol. Chem. 271 (4), 2255-2261 (1996)
Tang Z, Scherer PE, Okamoto T, Song K, Chu C, Kohtz DS, Nishimoto I, Lodish HF and Lisanti MP.


book

Evidence for a regulated interaction between heterotrimeric G proteins and caveolin
J. Biol. Chem. 270 (26), 15693-15701 (1995)
Li S, Okamoto T, Chun M, Sargiacomo M, Casanova JE, Hansen SH, Nishimoto I and Lisanti MP.


book

Caveolinopathies
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Bruno,C., Sotgia,F., Gazzerro,E., Minetti,C. and Lisanti,M.P.


book

Romano-Ward Syndrome
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Alders,M. and Mannens,M.M.A.M.


 
*
*
*
*