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PHOX2B cDNA ORF clone, Homo sapiens (human)

Gene Symbol PHOX2B
Entrez Gene ID 8929
Full Name paired-like homeobox 2b
Synonyms NBLST2, NBPhox, PMX2B
General protein information
Preferred Names
paired mesoderm homeobox protein 2B
Names
paired mesoderm homeobox protein 2B
neuroblastoma Phox
PHOX2B homeodomain protein
paired mesoderm homeobox 2b
neuroblastoma paired-type homeobox protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4p12

Summary The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

603851

Disorder Html: Central hypoventilation syndrome, congenital, 209880 (3);

mRNA and Protein(s)

mRNA Protein Name
NM_003924 NP_003915 paired mesoderm homeobox protein 2B



Homo sapiens (human) PHOX2B NP_003915.2
Pan troglodytes (chimpanzee) PHOX2B XP_001149518.1
Macaca mulatta (Rhesus monkey) PHOX2B XP_001098028.1
Canis lupus familiaris (dog) PHOX2B XP_852840.1
Mus musculus (house mouse) Phox2b NP_032914.1
Gallus gallus (chicken) PHOX2B XP_001234151.2
Danio rerio (zebrafish) phox2bb NP_001014818.1
Danio rerio (zebrafish) LOC101885818 XP_005157278.1
Xenopus (Silurana) tropicalis (western clawed frog) phox2b NP_001116492.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PHOX2B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PHOX2B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu26329 NM_003924 Homo sapiens paired-like homeobox 2b (PHOX2B), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $216.30
$309.00
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu26329
Clone ID Related Accession (Same CDS sequence) NM_003924
Accession Version NM_003924.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 945bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product paired mesoderm homeobox protein 2B
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D82344.1, BC017199.2, AC105389.3 and AI266171.1. This sequence is a reference standard in the RefSeqGene project. On Apr 4, 2008 this sequence version replaced gi:12707579. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D82344.1, BC017199.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145544 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGTATAAAA TGGAATATTC TTACCTCAAT TCCTCTGCCT ACGAGTCCTG TATGGCTGGG 
ATGGACACCT CGAGCCTGGC TTCAGCCTAT GCTGACTTCA GTTCCTGCAG CCAGGCCAGT
GGCTTCCAGT ATAACCCGAT AAGGACCACT TTTGGGGCCA CGTCCGGCTG CCCTTCCCTC
ACGCCGGGAT CCTGCAGCCT GGGCACCCTC AGGGACCACC AGAGCAGTCC GTACGCCGCA
GTTCCTTACA AACTCTTCAC GGACCACGGC GGCCTCAACG AGAAGCGCAA GCAGCGGCGC
ATCCGCACCA CTTTCACCAG TGCCCAGCTC AAAGAGCTGG AAAGGGTCTT CGCGGAGACT
CACTACCCCG ACATCTACAC TCGGGAGGAG CTGGCCCTGA AGATCGACCT CACAGAGGCG
CGAGTCCAGG TGTGGTTCCA GAACCGCCGC GCCAAGTTTC GCAAGCAGGA GCGCGCAGCG
GCAGCCGCAG CGGCCGCGGC CAAGAACGGC TCCTCGGGCA AAAAGTCTGA CTCTTCCAGG
GACGACGAGA GCAAAGAGGC CAAGAGCACT GACCCGGACA GCACTGGGGG CCCAGGTCCC
AATCCCAACC CCACCCCCAG CTGCGGGGCG AATGGAGGCG GCGGCGGCGG GCCCAGCCCG
GCTGGAGCTC CGGGGGCGGC GGGGCCCGGG GGCCCGGGAG GCGAACCCGG CAAGGGCGGC
GCAGCAGCAG CGGCGGCGGC CGCGGCAGCG GCGGCGGCGG CAGCGGCAGC GGCGGCAGCT
GGAGGCCTGG CTGCGGCTGG GGGCCCTGGA CAAGGCTGGG CTCCCGGCCC CGGCCCCATC
ACCTCCATCC CGGATTCGCT TGGGGGTCCC TTCGCCAGCG TCCTATCTTC GCTCCAAAGA
CCCAACGGTG CCAAAGCCGC CTTAGTGAAG AGCAGTATGT TCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_003915.2
CDS361..1305
Misc Feature(1)268..270(+)
Misc Feature(2)655..831(+)
Misc Feature(3)655..825(+)
Misc Feature(4)661..813(+)
Exon (1)1..601
Gene:PHOX2B
Gene Synonym:
Exon (2)602..789
Gene:PHOX2B
Gene Synonym:
Exon (3)790..3030
Gene:PHOX2B
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_003924
Organism Homo sapiens (human)
Definition Homo sapiens paired-like homeobox 2b (PHOX2B), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003924

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGTATAAAA TGGAATATTC TTACCTCAAT TCCTCTGCCT ACGAGTCCTG TATGGCTGGG 
ATGGACACCT CGAGCCTGGC TTCAGCCTAT GCTGACTTCA GTTCCTGCAG CCAGGCCAGT
GGCTTCCAGT ATAACCCGAT AAGGACCACT TTTGGGGCCA CGTCCGGCTG CCCTTCCCTC
ACGCCGGGAT CCTGCAGCCT GGGCACCCTC AGGGACCACC AGAGCAGTCC GTACGCCGCA
GTTCCTTACA AACTCTTCAC GGACCACGGC GGCCTCAACG AGAAGCGCAA GCAGCGGCGC
ATCCGCACCA CTTTCACCAG TGCCCAGCTC AAAGAGCTGG AAAGGGTCTT CGCGGAGACT
CACTACCCCG ACATCTACAC TCGGGAGGAG CTGGCCCTGA AGATCGACCT CACAGAGGCG
CGAGTCCAGG TGTGGTTCCA GAACCGCCGC GCCAAGTTTC GCAAGCAGGA GCGCGCAGCG
GCAGCCGCAG CGGCCGCGGC CAAGAACGGC TCCTCGGGCA AAAAGTCTGA CTCTTCCAGG
GACGACGAGA GCAAAGAGGC CAAGAGCACT GACCCGGACA GCACTGGGGG CCCAGGTCCC
AATCCCAACC CCACCCCCAG CTGCGGGGCG AATGGAGGCG GCGGCGGCGG GCCCAGCCCG
GCTGGAGCTC CGGGGGCGGC GGGGCCCGGG GGCCCGGGAG GCGAACCCGG CAAGGGCGGC
GCAGCAGCAG CGGCGGCGGC CGCGGCAGCG GCGGCGGCGG CAGCGGCAGC GGCGGCAGCT
GGAGGCCTGG CTGCGGCTGG GGGCCCTGGA CAAGGCTGGG CTCCCGGCCC CGGCCCCATC
ACCTCCATCC CGGATTCGCT TGGGGGTCCC TTCGCCAGCG TCCTATCTTC GCTCCAAAGA
CCCAACGGTG CCAAAGCCGC CTTAGTGAAG AGCAGTATGT TCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

[Congenital central hypoventilation syndrome: paradigm shifts and future prospects]
Nippon Rinsho 72 (2), 363-370 (2014)
Hayasaka K and Sasaki A.


book

A study of gata3 and phox2b expression in tumors of the autonomic nervous system
Am. J. Surg. Pathol. 37 (8), 1236-1241 (2013)
Nonaka D, Wang BY, Edmondson D, Beckett E and Sun CC.


book

Contributions of PHOX2B in the pathogenesis of Hirschsprung disease
PLoS ONE 8 (1), E54043 (2013)
Fernandez RM, Mathieu Y, Luzon-Toro B, Nunez-Torres R, Gonzalez-Meneses A, Antinolo G, Amiel J and Borrego S.


book

Congenital central hypoventilation syndrome with hirschsprung's disease due to PHOX2B gene mutation in a Turkish infant
Turk. J. Pediatr. 54 (5), 519-522 (2012)
Kaymakci A, Narter F, Yazar AS and Yilmaz MS.


book

Genomic structure and functional characterization of NBPhox (PMX2B), a homeodomain protein specific to catecholaminergic cells that is involved in second messenger-mediated transcriptional activation
Genomics 59 (1), 40-50 (1999)
Yokoyama M, Watanabe H and Nakamura M.


book

The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives
Nature 399 (6734), 366-370 (1999)
Pattyn A, Morin X, Cremer H, Goridis C and Brunet JF.


book

Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis
Development 124 (20), 4065-4075 (1997)
Pattyn A, Morin X, Cremer H, Goridis C and Brunet JF.


book

Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles
DNA Res. 3 (5), 311-320 (1996)
Yokoyama M, Nishi Y, Yoshii J, Okubo K and Matsubara K.


book

Hirschsprung Disease Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Parisi,M.A.


book

Congenital Central Hypoventilation Syndrome
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Weese-Mayer,D.E., Marazita,M.L., Rand,C.M. and Berry-Kravis,E.M.


 
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