The following PHOX2B gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PHOX2B gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 945bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||paired mesoderm homeobox protein 2B
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from D82344.1, BC017199.2,
AC105389.3 and AI266171.1.
This sequence is a reference standard in the RefSeqGene project.
On Apr 4, 2008 this sequence version replaced gi:12707579.
Summary: The DNA-associated protein encoded by this gene is a
member of the paired family of homeobox proteins localized to the
nucleus. The protein functions as a transcription factor involved
in the development of several major noradrenergic neuron
populations and the determination of neurotransmitter phenotype.
The gene product is linked to enhancement of second
messenger-mediated activation of the dopamine beta-hydroylase,
c-fos promoters and several enhancers, including cyclic
amp-response element and serum-response element. [provided by
RefSeq, Jul 2008].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because no single transcript was available
for the full length of the gene. The extent of this transcript is
supported by transcript alignments and orthologous data.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: D82344.1, BC017199.2 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.