||ORF Nucleotide Sequence (Length: 699bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC015724.9.
This sequence is a reference standard in the RefSeqGene project.
On Jun 4, 2008 this sequence version replaced gi:169881243.
Summary: The secreted polypeptide, encoded by this gene, binds and
inactivates members of the transforming growth factor-beta
(TGF-beta) superfamily signaling proteins, such as bone
morphogenetic protein-4 (BMP4). By diffusing through extracellular
matrices more efficiently than members of the TGF-beta superfamily,
this protein may have a principal role in creating morphogenic
gradients. The protein appears to have pleiotropic effect, both
early in development as well as in later stages. It was originally
isolated from Xenopus based on its ability to restore normal
dorsal-ventral body axis in embryos that had been artificially
ventralized by UV treatment. The results of the mouse knockout of
the ortholog suggest that it is involved in numerous developmental
processes, such as neural tube fusion and joint formation.
Recently, several dominant human NOG mutations in unrelated
families with proximal symphalangism (SYM1) and multiple synostoses
syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple
joint fusion as their principal feature, and map to the same region
(17q22) as this gene. All of these mutations altered evolutionarily
conserved amino acid residues. The amino acid sequence of this
human gene is highly homologous to that of Xenopus, rat and mouse.
[provided by RefSeq, Jul 2008].
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
COMPLETENESS: complete on the 3' end.