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NOG cDNA ORF clone, Homo sapiens (human)

Gene Symbol NOG
Entrez Gene ID 9241
Full Name noggin
Synonyms SYM1, SYNS1
General protein information
Preferred Names
noggin
Names
noggin
symphalangism 1 (proximal)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q22

Summary The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

602991

Disorder Html: Symphalangism, proximal, 185800 (3); Synostoses syndrome, multiple,

mRNA and Protein(s)

mRNA Protein Name
NM_005450 NP_005441 noggin precursor



Homo sapiens (human) NOG NP_005441.1
Pan troglodytes (chimpanzee) NOG XP_523802.2
Macaca mulatta (Rhesus monkey) NOG XP_001104355.1
Canis lupus familiaris (dog) NOG XP_005625045.1
Bos taurus (cattle) NOG XP_002695600.1
Mus musculus (house mouse) Nog NP_032737.1
Rattus norvegicus (Norway rat) Nog NP_037122.1
Gallus gallus (chicken) NOG NP_989454.1
Danio rerio (zebrafish) LOC100333103 XP_002664025.1
Danio rerio (zebrafish) nog3 NP_571057.1
Danio rerio (zebrafish) nog1 NP_571058.2
Xenopus (Silurana) tropicalis (western clawed frog) nog NP_001165369.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following NOG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NOG cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu19429
NM_005450 Homo sapiens noggin (NOG), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19429
Clone ID Related Accession (Same CDS sequence) NM_005450
Accession Version NM_005450.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 699bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 03-MAY-2014
Organism Homo sapiens (human)
Product noggin precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC015724.9. This sequence is a reference standard in the RefSeqGene project. On Jun 4, 2008 this sequence version replaced gi:169881243. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
ATGGAGCGCT GCCCCAGCCT AGGGGTCACC CTCTACGCCC TGGTGGTGGT CCTGGGGCTG 
CGGGCGACAC CGGCCGGCGG CCAGCACTAT CTCCACATCC GCCCGGCACC CAGCGACAAC
CTGCCCCTGG TGGACCTCAT CGAACACCCA GACCCTATCT TTGACCCCAA GGAAAAGGAT
CTGAACGAGA CGCTGCTGCG CTCGCTGCTC GGGGGCCACT ACGACCCAGG CTTCATGGCC
ACCTCGCCCC CCGAGGACCG GCCCGGCGGG GGCGGGGGTG CAGCTGGGGG CGCGGAGGAC
CTGGCGGAGC TGGACCAGCT GCTGCGGCAG CGGCCGTCGG GGGCCATGCC GAGCGAGATC
AAAGGGCTAG AGTTCTCCGA GGGCTTGGCC CAGGGCAAGA AGCAGCGCCT AAGCAAGAAG
CTGCGGAGGA AGTTACAGAT GTGGCTGTGG TCGCAGACAT TCTGCCCCGT GCTGTACGCG
TGGAACGACC TGGGCAGCCG CTTTTGGCCG CGCTACGTGA AGGTGGGCAG CTGCTTCAGT
AAGCGCTCGT GCTCCGTGCC CGAGGGCATG GTGTGCAAGC CGTCCAAGTC CGTGCACCTC
ACGGTGCTGC GGTGGCGCTG TCAGCGGCGC GGGGGCCAGC GCTGCGGCTG GATTCCCATC
CAGTACCCCA TCATTTCCGA GTGCAAGTGC TCGTGCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_005441.1
CDS526..1224
Misc Feature(1)103..105(+)
Misc Feature(2)550..1221(+)
Misc Feature(3)709..711(+)
Misc Feature(4)1144..1170(+)
Exon (1)1..1892
Gene:NOG
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_005450
Organism Homo sapiens (human)
Definition Homo sapiens noggin (NOG), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005450

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGAGCGCT GCCCCAGCCT AGGGGTCACC CTCTACGCCC TGGTGGTGGT CCTGGGGCTG 
CGGGCGACAC CGGCCGGCGG CCAGCACTAT CTCCACATCC GCCCGGCACC CAGCGACAAC
CTGCCCCTGG TGGACCTCAT CGAACACCCA GACCCTATCT TTGACCCCAA GGAAAAGGAT
CTGAACGAGA CGCTGCTGCG CTCGCTGCTC GGGGGCCACT ACGACCCAGG CTTCATGGCC
ACCTCGCCCC CCGAGGACCG GCCCGGCGGG GGCGGGGGTG CAGCTGGGGG CGCGGAGGAC
CTGGCGGAGC TGGACCAGCT GCTGCGGCAG CGGCCGTCGG GGGCCATGCC GAGCGAGATC
AAAGGGCTAG AGTTCTCCGA GGGCTTGGCC CAGGGCAAGA AGCAGCGCCT AAGCAAGAAG
CTGCGGAGGA AGTTACAGAT GTGGCTGTGG TCGCAGACAT TCTGCCCCGT GCTGTACGCG
TGGAACGACC TGGGCAGCCG CTTTTGGCCG CGCTACGTGA AGGTGGGCAG CTGCTTCAGT
AAGCGCTCGT GCTCCGTGCC CGAGGGCATG GTGTGCAAGC CGTCCAAGTC CGTGCACCTC
ACGGTGCTGC GGTGGCGCTG TCAGCGGCGC GGGGGCCAGC GCTGCGGCTG GATTCCCATC
CAGTACCCCA TCATTTCCGA GTGCAAGTGC TCGTGCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

An introduction of genetics in otosclerosis: a systematic review
Otolaryngol Head Neck Surg 150 (1), 34-39 (2014)
Bittermann AJ, Wegner I, Noordman BJ, Vincent R, van der Heijden GJ and Grolman W.


book

Multiple synostoses syndrome in three members of a family displaying a novel mutation in NOGGIN gene
J Plast Reconstr Aesthet Surg 66 (10), E287-E289 (2013)
Aydin,H.U., Altunoglu,U., Uyguner,Z.O., Ozkan,T. and Kayserili,H.


book

A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease
PLoS ONE 8 (8), E70174 (2013)
Ostensson M, Monten C, Bacelis J, Gudjonsdottir AH, Adamovic S, Ek J, Ascher H, Pollak E, Arnell H, Browaldh L, Agardh D, Wahlstrom J, Nilsson S and Torinsson-Naluai A.


book

The expression patterns of gremlin 1 and noggin in normal adult and tumor tissues
Int J Clin Exp Pathol 6 (7), 1400-1408 (2013)
Laurila R, Parkkila S, Isola J, Kallioniemi A and Alarmo EL.


book

Noggin attenuates the osteogenic activation of human valve interstitial cells in aortic valve sclerosis
Cardiovasc. Res. 98 (3), 402-410 (2013)
Poggio P, Sainger R, Branchetti E, Grau JB, Lai EK, Gorman RC, Sacks MS, Parolari A, Bavaria JE and Ferrari G.


book

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite
Genes Dev. 12 (10), 1438-1452 (1998)
McMahon JA, Takada S, Zimmerman LB, Fan CM, Harland RM and McMahon AP.


book

The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4
Cell 86 (4), 599-606 (1996)
Zimmerman LB, De Jesus-Escobar JM and Harland RM.


book

Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern
Development 121 (11), 3627-3636 (1995)
Lamb TM and Harland RM.


book

Identification of mammalian noggin and its expression in the adult nervous system
J. Neurosci. 15 (9), 6077-6084 (1995)
Valenzuela DM, Economides AN, Rojas E, Lamb TM, Nunez L, Jones P, Lp NY, Espinosa R 3rd, Brannan CI and Gilbert DJ.


book

Localization of the gene (SYM1) for proximal symphalangism to human chromosome 17q21-q22
Genomics 27 (2), 225-229 (1995)
Polymeropoulos MH, Poush J, Rubenstein JR and Francomano CA.


 
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