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NOG cDNA ORF clone, Homo sapiens (human)

Gene Symbol NOG
Entrez Gene ID 9241
Full Name noggin
Synonyms SYM1, SYNS1
General protein information
Preferred Names
noggin
Names
noggin
symphalangism 1 (proximal)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q22

Summary The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

602991

Disorder Html: Symphalangism, proximal, 185800 (3); Synostoses syndrome, multiple,





The following NOG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NOG cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu19429 NM_005450 Homo sapiens noggin (NOG), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$69.30
$99.00

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**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu19429
Accession Version NM_005450.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 699bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 03-MAY-2014
Organism Homo sapiens (human)
Product noggin precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC015724.9. This sequence is a reference standard in the RefSeqGene project. On Jun 4, 2008 this sequence version replaced gi:169881243. Summary: The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
ATGGAGCGCT GCCCCAGCCT AGGGGTCACC CTCTACGCCC TGGTGGTGGT CCTGGGGCTG 
CGGGCGACAC CGGCCGGCGG CCAGCACTAT CTCCACATCC GCCCGGCACC CAGCGACAAC
CTGCCCCTGG TGGACCTCAT CGAACACCCA GACCCTATCT TTGACCCCAA GGAAAAGGAT
CTGAACGAGA CGCTGCTGCG CTCGCTGCTC GGGGGCCACT ACGACCCAGG CTTCATGGCC
ACCTCGCCCC CCGAGGACCG GCCCGGCGGG GGCGGGGGTG CAGCTGGGGG CGCGGAGGAC
CTGGCGGAGC TGGACCAGCT GCTGCGGCAG CGGCCGTCGG GGGCCATGCC GAGCGAGATC
AAAGGGCTAG AGTTCTCCGA GGGCTTGGCC CAGGGCAAGA AGCAGCGCCT AAGCAAGAAG
CTGCGGAGGA AGTTACAGAT GTGGCTGTGG TCGCAGACAT TCTGCCCCGT GCTGTACGCG
TGGAACGACC TGGGCAGCCG CTTTTGGCCG CGCTACGTGA AGGTGGGCAG CTGCTTCAGT
AAGCGCTCGT GCTCCGTGCC CGAGGGCATG GTGTGCAAGC CGTCCAAGTC CGTGCACCTC
ACGGTGCTGC GGTGGCGCTG TCAGCGGCGC GGGGGCCAGC GCTGCGGCTG GATTCCCATC
CAGTACCCCA TCATTTCCGA GTGCAAGTGC TCGTGCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_005441.1
CDS526..1224
Misc Feature(1)103..105(+)
Misc Feature(2)550..1221(+)
Misc Feature(3)709..711(+)
Misc Feature(4)1144..1170(+)
Exon (1)1..1892
Gene:NOG
Gene Synonym:
Translation
Position Chain Variation Link
11 11 c, t dbSNP:768384296
23 23 -, cgc dbSNP:544678481
23 23 a, t dbSNP:761094923
68 68 a, c dbSNP:555144319
90 90 a, t dbSNP:572549428
117 117 c, t dbSNP:368706409
141 141 a, c dbSNP:117249328
142 142 c, g dbSNP:564728991
168 168 a, g dbSNP:531962500
179 179 a, c dbSNP:544092623
180 180 c, g dbSNP:576500971
197 197 c, g dbSNP:562377763
279 279 a, g dbSNP:528847079
281 281 a, g dbSNP:547461915
307 307 a, g dbSNP:540767778
353 353 a, g dbSNP:533084238
401 401 a, g dbSNP:551265826
453 453 a, g dbSNP:183274390
477 477 c, t dbSNP:755737643
480 480 c, t dbSNP:777801026
490 490 c, g dbSNP:753855182
505 505 c, t dbSNP:757043228
511 511 a, g dbSNP:778581661
512 512 c, t dbSNP:745733505
517 517 a, g dbSNP:772179196
523 523 a, g dbSNP:780362050
536 536 a, g dbSNP:747066445
542 542 c, g dbSNP:768756623
544 544 -, c dbSNP:34711886
545 545 g, t dbSNP:377157982
554 554 c, t dbSNP:762322014
555 555 c, t dbSNP:770391317
558 558 c, t dbSNP:773447794
561 561 c, t dbSNP:763418887
564 564 a, c, g dbSNP:767056711
565 565 c, g dbSNP:760219464
567 567 a, g dbSNP:763699646
570 570 g, t dbSNP:753766781
573 573 c, g dbSNP:757125599
583 583 c, g, t dbSNP:778974686
593 593 c, t dbSNP:138776675
595 595 c, t dbSNP:200253265
596 596 a, c dbSNP:747237879
600 600 c, t dbSNP:768664842
603 603 c, t dbSNP:781237616
618 618 a, c dbSNP:748297297
619 619 c, t dbSNP:770174138
621 621 c, t dbSNP:773820340
626 626 g, t dbSNP:763181672
628 628 c, g, t dbSNP:28937580
629 629 c, g dbSNP:104894611
632 632 c, t dbSNP:771355844
646 646 c, t dbSNP:772317007
652 652 c, g dbSNP:372535983
653 653 c, t dbSNP:763894353
659 659 a, g dbSNP:373452045
682 682 a, g dbSNP:761426737
690 690 c, t dbSNP:765062428
693 693 c, g dbSNP:750395838
695 695 a, g dbSNP:758063548
698 698 a, g dbSNP:766177414
702 702 a, g dbSNP:751414234
703 703 a, g dbSNP:117165670
708 708 c, g dbSNP:535456033
711 711 c, t dbSNP:748158680
719 719 c, t dbSNP:756242702
726 726 c, t dbSNP:778105304
733 733 c, t dbSNP:200290354
739 739 a, g dbSNP:147499492
740 740 a, g dbSNP:774839053
744 744 c, g dbSNP:746297352
750 750 c, g dbSNP:554180514
752 752 c, t dbSNP:776472075
754 754 c, g dbSNP:761177860
771 771 -, c dbSNP:749247710
771 771 a, g dbSNP:764833488
772 772 c, g dbSNP:772966707
773 773 a, c dbSNP:762937185
776 776 a, c, g, t dbSNP:138481449
777 777 c, g dbSNP:539891840
781 781 a, g dbSNP:760706732
788 788 a, c dbSNP:752998662
789 789 c, t dbSNP:756078666
790 790 a, g dbSNP:777919828
791 791 a, g dbSNP:749381932
792 792 a, c dbSNP:376069726
797 797 a, c, g dbSNP:375026622
800 800 a, g dbSNP:199566527
802 802 a, g dbSNP:776106273
803 803 g, t dbSNP:747852410
805 805 a, g dbSNP:777064118
812 812 c, g dbSNP:769391519
818 818 c, t dbSNP:772774248
826 826 c, t dbSNP:762410741
828 828 a, g dbSNP:770837708
830 830 c, g dbSNP:774298541
832 832 c, g dbSNP:759290193
833 833 a, t dbSNP:373305050
842 842 a, g dbSNP:576666126
847 847 c, t dbSNP:760935394
850 850 c, t dbSNP:764285839
853 853 c, t dbSNP:104894614
863 863 c, t dbSNP:371150691
864 864 c, g dbSNP:757461366
868 868 g, t dbSNP:779513643
875 875 c, g dbSNP:750997261
878 878 a, g dbSNP:544032242
883 883 a, c, g dbSNP:780454130
888 888 a, g dbSNP:769458009
892 892 c, t dbSNP:777342652
900 900 c, t dbSNP:748751127
906 906 a, g dbSNP:770461784
907 907 a, g dbSNP:774210447
909 909 c, t dbSNP:562364308
911 911 a, t dbSNP:104894613
915 915 c, t dbSNP:771958576
918 918 a, g dbSNP:775347315
929 929 a, g dbSNP:375219346
934 934 c, t dbSNP:764354713
946 946 c, t dbSNP:754029476
950 950 a, g dbSNP:369585713
973 973 g, t dbSNP:200203403
976 976 g, t dbSNP:750589581
977 977 c, g dbSNP:758969125
981 981 a, g dbSNP:780467799
984 984 a, g dbSNP:751932364
985 985 a, t dbSNP:755324318
1002 1002 c, t dbSNP:777444621
1021 1021 a, g dbSNP:773442175
1024 1024 c, g dbSNP:121908949
1042 1042 a, g dbSNP:748947432
1053 1053 c, t dbSNP:770373876
1060 1060 c, t dbSNP:778378498
1064 1064 a, g dbSNP:574424465
1074 1074 a, g dbSNP:772012301
1076 1076 a, g dbSNP:104894612
1081 1081 g, t dbSNP:372604336
1084 1084 -, c dbSNP:771054134
1086 1086 c, g, t dbSNP:202015803
1090 1090 g, t dbSNP:104894609
1101 1101 c, t dbSNP:375586586
1107 1107 a, g dbSNP:76347008
1109 1109 a, c dbSNP:765623058
1116 1116 c, g dbSNP:147334594
1117 1117 a, g dbSNP:763176857
1127 1127 c, t dbSNP:766861857
1128 1128 c, g dbSNP:752039942
1129 1129 c, g dbSNP:755307202
1136 1136 g, t dbSNP:104894610
1140 1140 c, g dbSNP:104894615
1143 1143 c, t dbSNP:370397639
1153 1153 a, c dbSNP:753114116
1156 1156 a, g dbSNP:756895131
1164 1164 g, t dbSNP:778574790
1174 1174 g, t dbSNP:104894603
1189 1189 g, t dbSNP:121908948
1190 1190 a, g dbSNP:104894602
1191 1191 c, t dbSNP:745356934
1193 1193 c, t dbSNP:104894608
1211 1211 a, g dbSNP:757867236
1221 1221 c, g, t dbSNP:387906844
1229 1229 c, t dbSNP:374850006
1232 1232 a, g dbSNP:532812087
1247 1247 a, t dbSNP:776564234
1272 1272 c, g dbSNP:747997574
1281 1281 c, t dbSNP:551421772
1285 1285 a, t dbSNP:760807689
1297 1297 c, g dbSNP:765020258
1304 1304 a, c dbSNP:1442829
1320 1320 a, g dbSNP:563056868
1334 1334 -, ttt dbSNP:765860967
1334 1334 -, tt dbSNP:541076214
1334 1334 c, t dbSNP:1236187
1335 1335 -, tt dbSNP:759111937
1358 1358 -, tt dbSNP:71139919
1362 1362 c, g dbSNP:199614572
1377 1377 a, g dbSNP:74256715
1402 1402 a, g dbSNP:752525475
1409 1409 c, t dbSNP:761700266
1428 1428 a, g dbSNP:548814783
1430 1430 a, g dbSNP:139325910
1434 1434 a, g dbSNP:534628693
1467 1467 a, g dbSNP:755091513
1513 1513 a, t dbSNP:546597764
1527 1527 a, c dbSNP:1348322
1532 1532 -, a dbSNP:144715174
1618 1618 a, g dbSNP:565308173
1639 1639 g, t dbSNP:566027663
1679 1679 c, t dbSNP:367951499
1725 1725 g, t dbSNP:558184389
1791 1791 c, g dbSNP:116716909
1830 1830 a, g dbSNP:187913874
1867 1867 a, c dbSNP:556028914
1888 1888 a, g dbSNP:561923410
1889 1889 a, g dbSNP:529295636

Target ORF information:

RefSeq Version NM_005450
Organism Homo sapiens (human)
Definition Homo sapiens noggin (NOG), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005450

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGAGCGCT GCCCCAGCCT AGGGGTCACC CTCTACGCCC TGGTGGTGGT CCTGGGGCTG 
CGGGCGACAC CGGCCGGCGG CCAGCACTAT CTCCACATCC GCCCGGCACC CAGCGACAAC
CTGCCCCTGG TGGACCTCAT CGAACACCCA GACCCTATCT TTGACCCCAA GGAAAAGGAT
CTGAACGAGA CGCTGCTGCG CTCGCTGCTC GGGGGCCACT ACGACCCAGG CTTCATGGCC
ACCTCGCCCC CCGAGGACCG GCCCGGCGGG GGCGGGGGTG CAGCTGGGGG CGCGGAGGAC
CTGGCGGAGC TGGACCAGCT GCTGCGGCAG CGGCCGTCGG GGGCCATGCC GAGCGAGATC
AAAGGGCTAG AGTTCTCCGA GGGCTTGGCC CAGGGCAAGA AGCAGCGCCT AAGCAAGAAG
CTGCGGAGGA AGTTACAGAT GTGGCTGTGG TCGCAGACAT TCTGCCCCGT GCTGTACGCG
TGGAACGACC TGGGCAGCCG CTTTTGGCCG CGCTACGTGA AGGTGGGCAG CTGCTTCAGT
AAGCGCTCGT GCTCCGTGCC CGAGGGCATG GTGTGCAAGC CGTCCAAGTC CGTGCACCTC
ACGGTGCTGC GGTGGCGCTG TCAGCGGCGC GGGGGCCAGC GCTGCGGCTG GATTCCCATC
CAGTACCCCA TCATTTCCGA GTGCAAGTGC TCGTGCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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