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MS4A1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol MS4A1
Entrez Gene ID 931
Full Name membrane-spanning 4-domains, subfamily A, member 1
Synonyms B1, Bp35, CD20, CVID5, LEU-16, MS4A2, S7
General protein information
Preferred Names
B-lymphocyte antigen CD20
Names
B-lymphocyte antigen CD20
CD20 antigen
CD20 receptor
leukocyte surface antigen Leu-16
B-lymphocyte cell-surface antigen B1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q12

Summary This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

112210

Disorder Html: Immunodeficiency, common variable, 5, 613495 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_152866 NP_690605 B-lymphocyte antigen CD20
NM_021950 NP_068769 B-lymphocyte antigen CD20



Homo sapiens (human) MS4A1 NP_690605.1
Pan troglodytes (chimpanzee) MS4A1 XP_508461.2
Macaca mulatta (Rhesus monkey) MS4A1 XP_001086364.1
Canis lupus familiaris (dog) MS4A1 NP_001041493.1
Bos taurus (cattle) MS4A1 NP_001071322.1
Mus musculus (house mouse) Ms4a1 NP_031667.1
Rattus norvegicus (Norway rat) Ms4a1 NP_001101048.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MS4A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MS4A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu00965
NM_152866 Homo sapiens membrane-spanning 4-domains, subfamily A, member 1 (MS4A1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu00965
NM_021950 Homo sapiens membrane-spanning 4-domains, subfamily A, member 1 (MS4A1), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu00965
Clone ID Related Accession (Same CDS sequence) NM_021950 , NM_152866
Accession Version NM_152866.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 894bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product B-lymphocyte antigen CD20
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD691924.1, AW504475.1, BC002807.2 and AP001034.5. This sequence is a reference standard in the RefSeqGene project. On Jun 30, 2005 this sequence version replaced gi:23110988. Transcript Variant: This variant (1) represents the longer transcript variant. Variants 1 and 3 both encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AK292168.1, X07203.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGACAACAC CCAGAAATTC AGTAAATGGG ACTTTCCCGG CAGAGCCAAT GAAAGGCCCT 
ATTGCTATGC AATCTGGTCC AAAACCACTC TTCAGGAGGA TGTCTTCACT GGTGGGCCCC
ACGCAAAGCT TCTTCATGAG GGAATCTAAG ACTTTGGGGG CTGTCCAGAT TATGAATGGG
CTCTTCCACA TTGCCCTGGG GGGTCTTCTG ATGATCCCAG CAGGGATCTA TGCACCCATC
TGTGTGACTG TGTGGTACCC TCTCTGGGGA GGCATTATGT ATATTATTTC CGGATCACTC
CTGGCAGCAA CGGAGAAAAA CTCCAGGAAG TGTTTGGTCA AAGGAAAAAT GATAATGAAT
TCATTGAGCC TCTTTGCTGC CATTTCTGGA ATGATTCTTT CAATCATGGA CATACTTAAT
ATTAAAATTT CCCATTTTTT AAAAATGGAG AGTCTGAATT TTATTAGAGC TCACACACCA
TATATTAACA TATACAACTG TGAACCAGCT AATCCCTCTG AGAAAAACTC CCCATCTACC
CAATACTGTT ACAGCATACA ATCTCTGTTC TTGGGCATTT TGTCAGTGAT GCTGATCTTT
GCCTTCTTCC AGGAACTTGT AATAGCTGGC ATCGTTGAGA ATGAATGGAA AAGAACGTGC
TCCAGACCCA AATCTAACAT AGTTCTCCTG TCAGCAGAAG AAAAAAAAGA ACAGACTATT
GAAATAAAAG AAGAAGTGGT TGGGCTAACT GAAACATCTT CCCAACCAAA GAATGAAGAA
GACATTGAAA TTATTCCAAT CCAAGAAGAG GAAGAAGAAG AAACAGAGAC GAACTTTCCA
GAACCTCCCC AAGATCAGGA ATCCTCACCA ATAGAAAATG ACAGCTCTCC TTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_690605.1
CDS417..1310
Misc Feature(1)342..344(+)
Misc Feature(2)567..1064(+)
Misc Feature(3)585..650(+)
Misc Feature(4)636..656(+)
Misc Feature(5)669..731(+)
Misc Feature(6)777..839(+)
Misc Feature(7)852..896(+)
Misc Feature(8)918..941(+)
Misc Feature(9)981..1043(+)
Misc Feature(10)1107..1109(+)
Misc Feature(11)1107..1109(+)
Misc Feature(12)1164..1166(+)
Misc Feature(13)1164..1166(+)
Misc Feature(14)1281..1283(+)
Misc Feature(15)1281..1283(+)
Exon (1)1..137
Gene:MS4A1
Gene Synonym:
Exon (2)138..226
Gene:MS4A1
Gene Synonym:
Exon (3)227..575
Gene:MS4A1
Gene Synonym:
Exon (4)576..695
Gene:MS4A1
Gene Synonym:
Exon (5)696..752
Gene:MS4A1
Gene Synonym:
Exon (6)753..989
Gene:MS4A1
Gene Synonym:
Exon (7)990..1091
Gene:MS4A1
Gene Synonym:
Exon (8)1092..3594
Gene:MS4A1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_152866
Organism Homo sapiens (human)
Definition Homo sapiens membrane-spanning 4-domains, subfamily A, member 1 (MS4A1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_152866

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGACAACAC CCAGAAATTC AGTAAATGGG ACTTTCCCGG CAGAGCCAAT GAAAGGCCCT 
ATTGCTATGC AATCTGGTCC AAAACCACTC TTCAGGAGGA TGTCTTCACT GGTGGGCCCC
ACGCAAAGCT TCTTCATGAG GGAATCTAAG ACTTTGGGGG CTGTCCAGAT TATGAATGGG
CTCTTCCACA TTGCCCTGGG GGGTCTTCTG ATGATCCCAG CAGGGATCTA TGCACCCATC
TGTGTGACTG TGTGGTACCC TCTCTGGGGA GGCATTATGT ATATTATTTC CGGATCACTC
CTGGCAGCAA CGGAGAAAAA CTCCAGGAAG TGTTTGGTCA AAGGAAAAAT GATAATGAAT
TCATTGAGCC TCTTTGCTGC CATTTCTGGA ATGATTCTTT CAATCATGGA CATACTTAAT
ATTAAAATTT CCCATTTTTT AAAAATGGAG AGTCTGAATT TTATTAGAGC TCACACACCA
TATATTAACA TATACAACTG TGAACCAGCT AATCCCTCTG AGAAAAACTC CCCATCTACC
CAATACTGTT ACAGCATACA ATCTCTGTTC TTGGGCATTT TGTCAGTGAT GCTGATCTTT
GCCTTCTTCC AGGAACTTGT AATAGCTGGC ATCGTTGAGA ATGAATGGAA AAGAACGTGC
TCCAGACCCA AATCTAACAT AGTTCTCCTG TCAGCAGAAG AAAAAAAAGA ACAGACTATT
GAAATAAAAG AAGAAGTGGT TGGGCTAACT GAAACATCTT CCCAACCAAA GAATGAAGAA
GACATTGAAA TTATTCCAAT CCAAGAAGAG GAAGAAGAAG AAACAGAGAC GAACTTTCCA
GAACCTCCCC AAGATCAGGA ATCCTCACCA ATAGAAAATG ACAGCTCTCC TTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu00965
Clone ID Related Accession (Same CDS sequence) NM_021950 , NM_152866
Accession Version NM_021950.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 894bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product B-lymphocyte antigen CD20
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD691924.1, BC002807.2 and AP001034.5. On Jun 30, 2005 this sequence version replaced gi:23110986. Transcript Variant: This variant (3) lacks a portion of the 5' UTR, compared to variant 1, but encodes the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X07203.1, BC002807.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGACAACAC CCAGAAATTC AGTAAATGGG ACTTTCCCGG CAGAGCCAAT GAAAGGCCCT 
ATTGCTATGC AATCTGGTCC AAAACCACTC TTCAGGAGGA TGTCTTCACT GGTGGGCCCC
ACGCAAAGCT TCTTCATGAG GGAATCTAAG ACTTTGGGGG CTGTCCAGAT TATGAATGGG
CTCTTCCACA TTGCCCTGGG GGGTCTTCTG ATGATCCCAG CAGGGATCTA TGCACCCATC
TGTGTGACTG TGTGGTACCC TCTCTGGGGA GGCATTATGT ATATTATTTC CGGATCACTC
CTGGCAGCAA CGGAGAAAAA CTCCAGGAAG TGTTTGGTCA AAGGAAAAAT GATAATGAAT
TCATTGAGCC TCTTTGCTGC CATTTCTGGA ATGATTCTTT CAATCATGGA CATACTTAAT
ATTAAAATTT CCCATTTTTT AAAAATGGAG AGTCTGAATT TTATTAGAGC TCACACACCA
TATATTAACA TATACAACTG TGAACCAGCT AATCCCTCTG AGAAAAACTC CCCATCTACC
CAATACTGTT ACAGCATACA ATCTCTGTTC TTGGGCATTT TGTCAGTGAT GCTGATCTTT
GCCTTCTTCC AGGAACTTGT AATAGCTGGC ATCGTTGAGA ATGAATGGAA AAGAACGTGC
TCCAGACCCA AATCTAACAT AGTTCTCCTG TCAGCAGAAG AAAAAAAAGA ACAGACTATT
GAAATAAAAG AAGAAGTGGT TGGGCTAACT GAAACATCTT CCCAACCAAA GAATGAAGAA
GACATTGAAA TTATTCCAAT CCAAGAAGAG GAAGAAGAAG AAACAGAGAC GAACTTTCCA
GAACCTCCCC AAGATCAGGA ATCCTCACCA ATAGAAAATG ACAGCTCTCC TTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_068769.2
CDS154..1047
Misc Feature(1)112..114(+)
Misc Feature(2)304..801(+)
Misc Feature(3)322..387(+)
Misc Feature(4)373..393(+)
Misc Feature(5)406..468(+)
Misc Feature(6)514..576(+)
Misc Feature(7)589..633(+)
Misc Feature(8)655..678(+)
Misc Feature(9)718..780(+)
Misc Feature(10)844..846(+)
Misc Feature(11)844..846(+)
Misc Feature(12)901..903(+)
Misc Feature(13)901..903(+)
Misc Feature(14)1018..1020(+)
Misc Feature(15)1018..1020(+)
Exon (1)1..137
Gene:MS4A1
Gene Synonym:
Exon (2)138..312
Gene:MS4A1
Gene Synonym:
Exon (3)313..432
Gene:MS4A1
Gene Synonym:
Exon (4)433..489
Gene:MS4A1
Gene Synonym:
Exon (5)490..726
Gene:MS4A1
Gene Synonym:
Exon (6)727..828
Gene:MS4A1
Gene Synonym:
Exon (7)829..3331
Gene:MS4A1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_021950
Organism Homo sapiens (human)
Definition Homo sapiens membrane-spanning 4-domains, subfamily A, member 1 (MS4A1), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_021950

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGACAACAC CCAGAAATTC AGTAAATGGG ACTTTCCCGG CAGAGCCAAT GAAAGGCCCT 
ATTGCTATGC AATCTGGTCC AAAACCACTC TTCAGGAGGA TGTCTTCACT GGTGGGCCCC
ACGCAAAGCT TCTTCATGAG GGAATCTAAG ACTTTGGGGG CTGTCCAGAT TATGAATGGG
CTCTTCCACA TTGCCCTGGG GGGTCTTCTG ATGATCCCAG CAGGGATCTA TGCACCCATC
TGTGTGACTG TGTGGTACCC TCTCTGGGGA GGCATTATGT ATATTATTTC CGGATCACTC
CTGGCAGCAA CGGAGAAAAA CTCCAGGAAG TGTTTGGTCA AAGGAAAAAT GATAATGAAT
TCATTGAGCC TCTTTGCTGC CATTTCTGGA ATGATTCTTT CAATCATGGA CATACTTAAT
ATTAAAATTT CCCATTTTTT AAAAATGGAG AGTCTGAATT TTATTAGAGC TCACACACCA
TATATTAACA TATACAACTG TGAACCAGCT AATCCCTCTG AGAAAAACTC CCCATCTACC
CAATACTGTT ACAGCATACA ATCTCTGTTC TTGGGCATTT TGTCAGTGAT GCTGATCTTT
GCCTTCTTCC AGGAACTTGT AATAGCTGGC ATCGTTGAGA ATGAATGGAA AAGAACGTGC
TCCAGACCCA AATCTAACAT AGTTCTCCTG TCAGCAGAAG AAAAAAAAGA ACAGACTATT
GAAATAAAAG AAGAAGTGGT TGGGCTAACT GAAACATCTT CCCAACCAAA GAATGAAGAA
GACATTGAAA TTATTCCAAT CCAAGAAGAG GAAGAAGAAG AAACAGAGAC GAACTTTCCA
GAACCTCCCC AAGATCAGGA ATCCTCACCA ATAGAAAATG ACAGCTCTCC TTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

CD20 antigen may be expressed by reactive or lymphomatous cells of transformed mycosis fungoides: diagnostic and prognostic impact
Am. J. Surg. Pathol. 37 (12), 1845-1854 (2013)
Jullie ML, Carlotti M, Vivot A Jr, Beylot-Barry M, Ortonne N, Frouin E, Carlotti A, de Muret A, Balme B, Franck F, Merlio JP and Vergier B.


book

High levels of CD20 expression predict good prognosis in chronic lymphocytic leukemia
Cancer Sci. 104 (8), 996-1001 (2013)
Fang C, Zhuang Y, Wang L, Fan L, Wu YJ, Zhang R, Zou ZJ, Zhang LN, Yang S, Xu W and Li JY.


book

Development of an ELISA based bridging assay as a surrogate measure of ADCC
J. Immunol. Methods 385 (1-2), 45-50 (2012)
Miller AS, Tejada ML and Gazzano-Santoro H.


book

Prenyltransferases regulate CD20 protein levels and influence anti-CD20 monoclonal antibody-mediated activation of complement-dependent cytotoxicity
J. Biol. Chem. 287 (38), 31983-31993 (2012)
Winiarska M, Nowis D, Bil J, Glodkowska-Mrowka E, Muchowicz A, Wanczyk M, Bojarczuk K, Dwojak M, Firczuk M, Wilczek E, Wachowska M, Roszczenko K, Miaczynska M, Chlebowska J, Basak GW and Golab J.


book

CD20-positive NK/T-cell lymphoma with indolent clinical course: report of case and review of literature
Diagn Pathol 7, 133 (2012)
Jiang QP, Liu SY, Yang YX, Tan XX, Peng J, Xiong ZT and Li Z.


book

The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor
J. Biol. Chem. 267 (18), 12782-12787 (1992)
Kuster H, Zhang L, Brini AT, MacGlashan DW and Kinet JP.


book

Structure of the gene encoding the human B lymphocyte differentiation antigen CD20 (B1)
J. Immunol. 142 (7), 2560-2568 (1989)
Tedder TF, Klejman G, Schlossman SF and Saito H.


book

The gene that encodes the human CD20 (B1) differentiation antigen is located on chromosome 11 near the t(11;14)(q13;q32) translocation site
J. Immunol. 142 (7), 2555-2559 (1989)
Tedder TF, Disteche CM, Louie E, Adler DA, Croce CM, Schlossman SF and Saito H.


book

Molecular cloning of the human B cell CD20 receptor predicts a hydrophobic protein with multiple transmembrane domains
EMBO J. 7 (3), 711-717 (1988)
Einfeld DA, Brown JP, Valentine MA, Clark EA and Ledbetter JA.


book

Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes
Proc. Natl. Acad. Sci. U.S.A. 85 (1), 208-212 (1988)
Tedder TF, Streuli M, Schlossman SF and Saito H.


 
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