The following MMP20 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MMP20 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 1452bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||matrix metalloproteinase-20 preproprotein
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from Y12779.1 and AJ296177.1.
This sequence is a reference standard in the RefSeqGene project.
On Mar 11, 2004 this sequence version replaced gi:13027805.
Summary: Proteins of the matrix metalloproteinase (MMP) family are
involved in the breakdown of extracellular matrix in normal
physiological processes, such as embryonic development,
reproduction, and tissue remodeling, as well as in disease
processes, such as arthritis and metastasis. Most MMP's are
secreted as inactive proproteins which are activated when cleaved
by extracellular proteinases. The protein encoded by this gene
degrades amelogenin, the major protein component of dental enamel
matrix, and thus thought to play a role in tooth enamel formation.
A mutation in this gene, which alters the normal splice pattern and
results in premature termination of the encoded protein, has been
associated with amelogenesis imperfecta. This gene is part of a
cluster of MMP genes located on chromosome 11q22.3. [provided by
RefSeq, Aug 2011].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: Y12779.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
COMPLETENESS: complete on the 3' end.