||ORF Nucleotide Sequence (Length: 801bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||integral membrane protein 2B
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA087198.1, AK130048.1,
AF136973.1 and AF152462.1.
This sequence is a reference standard in the RefSeqGene project.
On Jan 24, 2009 this sequence version replaced gi:142388886.
Summary: Amyloid precursor proteins are processed by beta-secretase
and gamma-secretase to produce beta-amyloid peptides which form the
characteristic plaques of Alzheimer disease. This gene encodes a
transmembrane protein which is processed at the C-terminus by furin
or furin-like proteases to produce a small secreted peptide which
inhibits the deposition of beta-amyloid. Mutations which result in
extension of the C-terminal end of the encoded protein, thereby
increasing the size of the secreted peptide, are associated with
two neurogenerative diseases, familial British dementia and
familial Danish dementia. [provided by RefSeq, Oct 2009].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: AF152462.1, AF136973.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.