The following ITM2B gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ITM2B gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 801bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||integral membrane protein 2B
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA087198.1, AK130048.1,
AF136973.1 and AF152462.1.
This sequence is a reference standard in the RefSeqGene project.
On Jan 24, 2009 this sequence version replaced gi:142388886.
Summary: Amyloid precursor proteins are processed by beta-secretase
and gamma-secretase to produce beta-amyloid peptides which form the
characteristic plaques of Alzheimer disease. This gene encodes a
transmembrane protein which is processed at the C-terminus by furin
or furin-like proteases to produce a small secreted peptide which
inhibits the deposition of beta-amyloid. Mutations which result in
extension of the C-terminal end of the encoded protein, thereby
increasing the size of the secreted peptide, are associated with
two neurogenerative diseases, familial British dementia and
familial Danish dementia. [provided by RefSeq, Oct 2009].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: AF152462.1, AF136973.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.