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ITM2B integral membrane protein 2B [Homo sapiens (human)]

Gene Symbol ITM2B
Entrez Gene ID 9445
Full Name integral membrane protein 2B
Synonyms ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, RDGCA, imBRI2
General protein information
Preferred Names
integral membrane protein 2B
Names
integral membrane protein 2B
immature BRI2
ABri/ADan amyloid peptide
transmembrane protein BRI
BRICHOS domain containing 2B
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

13

13q14.3

Summary Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]. lac of sum
Disorder MIM:

603904

Disorder Html: Dementia, familial British, 176500 (3); Dementia, familial Danish,





The following ITM2B gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ITM2B gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu27275 NM_021999 Homo sapiens integral membrane protein 2B (ITM2B), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$139.3
$199

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu27275
Accession Version NM_021999.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 801bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product integral membrane protein 2B
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA087198.1, AK130048.1, AF136973.1 and AF152462.1. This sequence is a reference standard in the RefSeqGene project. On Jan 24, 2009 this sequence version replaced gi:142388886. Summary: Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF152462.1, AF136973.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGTGAAGG TGACGTTCAA CTCCGCTCTG GCCCAGAAGG AGGCCAAGAA GGACGAGCCC 
AAGAGCGGCG AGGAGGCGCT CATCATCCCC CCCGACGCCG TCGCGGTGGA CTGCAAGGAC
CCAGATGATG TGGTACCAGT TGGCCAAAGA AGAGCCTGGT GTTGGTGCAT GTGCTTTGGA
CTAGCATTTA TGCTTGCAGG TGTTATTCTA GGAGGAGCAT ACTTGTACAA ATATTTTGCA
CTTCAACCAG ATGACGTGTA CTACTGTGGA ATAAAGTACA TCAAAGATGA TGTCATCTTA
AATGAGCCCT CTGCAGATGC CCCAGCTGCT CTCTACCAGA CAATTGAAGA AAATATTAAA
ATCTTTGAAG AAGAAGAAGT TGAATTTATC AGTGTGCCTG TCCCAGAGTT TGCAGATAGT
GATCCTGCCA ACATTGTTCA TGACTTTAAC AAGAAACTTA CAGCCTATTT AGATCTTAAC
CTGGATAAGT GCTATGTGAT CCCTCTGAAC ACTTCCATTG TTATGCCACC CAGAAACCTA
CTGGAGTTAC TTATTAACAT CAAGGCTGGA ACCTATTTGC CTCAGTCCTA TCTGATTCAT
GAGCACATGG TTATTACTGA TCGCATTGAA AACATTGATC ACCTGGGTTT CTTTATTTAT
CGACTGTGTC ATGACAAGGA AACTTACAAA CTGCAACGCA GAGAAACTAT TAAAGGTATT
CAGAAACGTG AAGCCAGCAA TTGTTTCGCA ATTCGGCATT TTGAAAACAA ATTTGCCGTG
GAAACTTTAA TTTGTTCTTG A
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_068839.1
CDS224..1024
Misc Feature(1)71..73(+)
Misc Feature(2)386..448(+)
Misc Feature(3)527..625(+)
Misc Feature(4)632..916(+)
Misc Feature(5)950..955(+)
Exon (1)1..340
Gene:ITM2B
Gene Synonym:
Exon (2)341..469
Gene:ITM2B
Gene Synonym:
Exon (3)470..676
Gene:ITM2B
Gene Synonym:
Exon (4)677..787
Gene:ITM2B
Gene Synonym:
Exon (5)788..938
Gene:ITM2B
Gene Synonym:
Exon (6)939..1896
Gene:ITM2B
Gene Synonym:
Translation
Position Chain Variation Link
58 58 a, g dbSNP:549899044
66 66 a, c dbSNP:375837803
70 70 c, g dbSNP:571519655
82 82 g, t dbSNP:539024187
84 84 c, t dbSNP:554126468
88 88 a, g dbSNP:11556902
95 95 a, t dbSNP:769217205
114 114 g, t dbSNP:572688262
119 119 a, g dbSNP:536989630
127 127 c, t dbSNP:532372951
161 161 c, g dbSNP:11556903
179 179 g, t dbSNP:765109304
187 187 -, ccg dbSNP:531403426
199 199 c, t dbSNP:752549116
209 209 a, g dbSNP:758061168
212 212 a, c dbSNP:11556904
213 213 c, t dbSNP:763943060
214 214 a, c, g dbSNP:552198156
218 218 c, t dbSNP:576743598
219 219 a, c, g dbSNP:11556906
221 221 g, t dbSNP:780316156
238 238 a, c, g dbSNP:543509091
243 243 a, g dbSNP:779234032
248 248 c, g dbSNP:748552422
258 258 -, aga dbSNP:745799929
262 262 a, g dbSNP:565013505
266 266 a, g dbSNP:11556905
278 278 a, g dbSNP:772385941
283 283 c, t dbSNP:778187781
289 289 c, t dbSNP:746714921
296 296 a, g dbSNP:770539704
304 304 c, t dbSNP:11556899
308 308 a, g dbSNP:758987944
309 309 -, c dbSNP:746700992
310 310 -, c dbSNP:779515110
311 311 a, c, t dbSNP:769773974
315 315 a, c, g dbSNP:150336652
316 316 c, t dbSNP:751333259
328 328 g, t dbSNP:761013044
329 329 a, g dbSNP:766663901
332 332 a, g dbSNP:753982738
346 346 a, g dbSNP:11556907
349 349 a, t dbSNP:762835471
351 351 a, t dbSNP:768593758
353 353 -, gtg dbSNP:748399761
354 354 g, t dbSNP:774313921
355 355 a, g dbSNP:761646574
359 359 c, g, t dbSNP:766715423
367 367 c, t dbSNP:759821284
370 370 -, aag dbSNP:770194883
370 370 a, t dbSNP:765283434
378 378 c, t dbSNP:752792298
392 392 a, c dbSNP:149490262
394 394 a, g dbSNP:765682225
403 403 a, g dbSNP:528817179
408 408 c, t dbSNP:764604146
424 424 c, t dbSNP:17849339
425 425 g, t dbSNP:751925702
427 427 c, t dbSNP:374098900
429 429 c, t dbSNP:781522686
440 440 c, g dbSNP:745566936
463 463 a, t dbSNP:755757477
470 470 a, c, t dbSNP:201982776
476 476 a, g dbSNP:143931252
478 478 c, t dbSNP:74074155
479 479 a, g dbSNP:749707917
507 507 a, c dbSNP:113956182
522 522 g, t dbSNP:755741361
533 533 c, t dbSNP:779702752
539 539 g, t dbSNP:757484295
546 546 c, t dbSNP:754586409
547 547 a, g dbSNP:9332284
548 548 g, t dbSNP:748146945
559 559 c, t dbSNP:377585277
563 563 a, g dbSNP:541331841
568 568 a, c, t dbSNP:746769961
579 579 c, t dbSNP:775848254
586 586 a, c dbSNP:763071123
588 588 c, t dbSNP:764206598
590 590 -, gaagaa dbSNP:751018650
590 590 -, gaa dbSNP:779568121
594 594 a, g dbSNP:370484810
600 600 a, t dbSNP:762336440
601 601 a, t dbSNP:767959003
608 608 g, t dbSNP:750762827
626 626 c, t dbSNP:200085682
631 631 a, g dbSNP:766650893
636 636 c, t dbSNP:753588397
640 640 c, t dbSNP:754657407
641 641 a, g dbSNP:778609115
659 659 -, t dbSNP:754668102
659 659 c, g dbSNP:771173753
675 675 a, g dbSNP:752215006
682 682 -, a dbSNP:770108628
715 715 c, t dbSNP:11556900
723 723 c, t dbSNP:141232990
728 728 c, t dbSNP:764934794
734 734 a, c dbSNP:752270142
740 740 a, c dbSNP:758048491
742 742 g, t dbSNP:777134037
743 743 a, g dbSNP:146286944
749 749 a, c, t dbSNP:757109548
755 755 a, g dbSNP:180832133
759 759 a, g dbSNP:768875245
772 772 a, g dbSNP:779036982
780 780 a, g dbSNP:748368864
801 801 c, t dbSNP:747013966
806 806 a, c dbSNP:11556901
808 808 c, g dbSNP:373587210
811 811 c, g, t dbSNP:201852577
813 813 a, g dbSNP:770332292
829 829 c, t dbSNP:775963867
845 845 c, t dbSNP:762725137
846 846 a, g dbSNP:201399334
860 860 a, g dbSNP:773922518
882 882 a, g dbSNP:761159398
884 884 c, t dbSNP:767045938
885 885 a, g dbSNP:199884227
905 905 a, g dbSNP:760214237
911 911 a, g dbSNP:763629732
920 920 c, t dbSNP:756025247
921 921 a, g dbSNP:368050477
928 928 a, g dbSNP:753591191
933 933 c, t dbSNP:371745063
937 937 a, g dbSNP:777802039
941 941 a, g dbSNP:759189041
970 970 c, g, t dbSNP:765077508
971 971 a, g, t dbSNP:578006622
974 974 a, g dbSNP:139394220
979 979 g, t dbSNP:201018568
997 997 c, t dbSNP:144217555
1000 1000 c, g, t dbSNP:146553069
1001 1001 a, g dbSNP:373968526
1005 1005 a, c dbSNP:606231283
1009 1009 a, t dbSNP:779316985
1011 1011 c, t dbSNP:747798420
1013 1013 a, g dbSNP:771676204
1018 1018 -, tttaatttgt dbSNP:606231166
1022 1022 a, t dbSNP:104894417
1027 1027 a, g dbSNP:772731795
1031 1031 a, g dbSNP:749553051
1035 1035 a, g dbSNP:760120359
1039 1039 c, t dbSNP:770862229
1042 1042 c, t dbSNP:776617945
1044 1044 c, t dbSNP:759493813
1057 1057 a, g dbSNP:368947914
1059 1059 a, g dbSNP:376535006
1060 1060 c, t dbSNP:771097385
1061 1061 c, g dbSNP:761962927
1063 1063 c, t dbSNP:15059
1133 1133 a, c dbSNP:111489798
1149 1149 g, t dbSNP:748256877
1167 1167 a, t dbSNP:9332304
1168 1168 a, g dbSNP:566768439
1188 1188 a, g dbSNP:11556898
1191 1191 c, t dbSNP:535543297
1192 1192 a, t dbSNP:1053852
1249 1249 a, g dbSNP:9332305
1259 1259 c, t dbSNP:149011622
1263 1263 g, t dbSNP:532090716
1290 1290 a, g dbSNP:555473125
1302 1302 a, c dbSNP:111774271
1309 1309 c, t dbSNP:9332306
1355 1355 a, c dbSNP:769317144
1360 1360 a, g dbSNP:770198608
1373 1373 c, t dbSNP:772558230
1379 1379 c, t dbSNP:571819815
1428 1428 a, g dbSNP:532064172
1442 1442 c, t dbSNP:143797646
1451 1451 g, t dbSNP:565672050
1499 1499 a, t dbSNP:148194760
1509 1509 g, t dbSNP:762708690
1515 1515 a, g dbSNP:775988869
1516 1516 c, t dbSNP:559696686
1533 1533 a, c dbSNP:3194840
1601 1601 a, g dbSNP:766061275
1617 1617 a, g dbSNP:187075131
1679 1679 c, t dbSNP:141149671
1680 1680 a, g dbSNP:575210968
1694 1694 a, g dbSNP:763253404
1711 1711 a, g dbSNP:764472211
1726 1726 a, c dbSNP:9534999
1727 1727 a, c dbSNP:558422474
1728 1728 a, c, g dbSNP:576992224
1785 1785 c, t dbSNP:545135253
1830 1830 c, g dbSNP:751958724
1870 1870 g, t dbSNP:538260036

Target ORF information:

RefSeq Version NM_021999
Organism Homo sapiens (human)
Definition Homo sapiens integral membrane protein 2B (ITM2B), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_021999

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGTGAAGG TGACGTTCAA CTCCGCTCTG GCCCAGAAGG AGGCCAAGAA GGACGAGCCC 
AAGAGCGGCG AGGAGGCGCT CATCATCCCC CCCGACGCCG TCGCGGTGGA CTGCAAGGAC
CCAGATGATG TGGTACCAGT TGGCCAAAGA AGAGCCTGGT GTTGGTGCAT GTGCTTTGGA
CTAGCATTTA TGCTTGCAGG TGTTATTCTA GGAGGAGCAT ACTTGTACAA ATATTTTGCA
CTTCAACCAG ATGACGTGTA CTACTGTGGA ATAAAGTACA TCAAAGATGA TGTCATCTTA
AATGAGCCCT CTGCAGATGC CCCAGCTGCT CTCTACCAGA CAATTGAAGA AAATATTAAA
ATCTTTGAAG AAGAAGAAGT TGAATTTATC AGTGTGCCTG TCCCAGAGTT TGCAGATAGT
GATCCTGCCA ACATTGTTCA TGACTTTAAC AAGAAACTTA CAGCCTATTT AGATCTTAAC
CTGGATAAGT GCTATGTGAT CCCTCTGAAC ACTTCCATTG TTATGCCACC CAGAAACCTA
CTGGAGTTAC TTATTAACAT CAAGGCTGGA ACCTATTTGC CTCAGTCCTA TCTGATTCAT
GAGCACATGG TTATTACTGA TCGCATTGAA AACATTGATC ACCTGGGTTT CTTTATTTAT
CGACTGTGTC ATGACAAGGA AACTTACAAA CTGCAACGCA GAGAAACTAT TAAAGGTATT
CAGAAACGTG AAGCCAGCAA TTGTTTCGCA ATTCGGCATT TTGAAAACAA ATTTGCCGTG
GAAACTTTAA TTTGTTCTTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.