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MAFB cDNA ORF clone, Homo sapiens (human)

Gene Symbol MAFB
Entrez Gene ID 9935
Full Name v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
Synonyms KRML, MCTO
General protein information
Preferred Names
transcription factor MafB
Names
transcription factor MafB
Kreisler maf-related leucine zipper homolog
MAFB/Kreisler basic region/leucine zipper transcription factor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

20

20q12

Summary The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

608968


mRNA and Protein(s)

mRNA Protein Name
NM_005461 NP_005452 transcription factor MafB


Homo sapiens (human) MAFB NP_005452.2
Pan troglodytes (chimpanzee) MAFB XP_525325.3
Macaca mulatta (Rhesus monkey) LOC712578 XP_001101624.2
Bos taurus (cattle) MAFB XP_002692508.1
Mus musculus (house mouse) Mafb NP_034788.1
Rattus norvegicus (Norway rat) Mafb NP_062189.1
Gallus gallus (chicken) MAFB NP_001026023.1
Xenopus (Silurana) tropicalis (western clawed frog) mafb NP_001025694.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MAFB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAFB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu25119
NM_005461 Homo sapiens v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$154.50-$216.30
$309.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
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30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu25119
Clone ID Related Accession (Same CDS sequence) NM_005461
Accession Version NM_005461.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 972bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 04-FEB-2015
Organism Homo sapiens (human)
Product transcription factor MafB
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA719830.1, BC028098.1, AF134157.1 and BQ271704.1. This sequence is a reference standard in the RefSeqGene project. On Jul 2, 2013 this sequence version replaced gi:31652256. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGCCGCGG AGCTGAGCAT GGGGCCAGAG CTGCCCACCA GCCCGCTGGC CATGGAGTAT 
GTCAACGACT TCGACCTGCT CAAGTTCGAC GTGAAGAAGG AGCCACTGGG GCGCGCGGAG
CGTCCGGGCA GGCCCTGCAC ACGCCTGCAG CCAGCCGGCT CGGTGTCCTC CACACCGCTC
AGCACTCCGT GTAGCTCCGT GCCCTCGTCG CCCAGCTTCA GCCCGACCGA ACAGAAGACA
CACCTCGAGG ATCTGTACTG GATGGCGAGC AACTACCAGC AGATGAACCC CGAGGCGCTC
AACCTGACGC CCGAGGACGC GGTGGAAGCG CTCATCGGCT CGCACCCAGT GCCACAGCCG
CTGCAAAGCT TCGACAGCTT TCGCGGCGCT CACCACCACC ACCATCACCA CCACCCTCAC
CCGCACCACG CGTACCCGGG CGCCGGCGTG GCCCACGACG AGCTGGGCCC GCACGCTCAC
CCGCACCATC ACCATCATCA CCAAGCGTCG CCGCCGCCGT CCAGCGCCGC TAGCCCGGCG
CAACAGCTGC CCACTAGCCA CCCCGGGCCC GGGCCGCACG CGACGGCCTC GGCGACGGCG
GCGGGCGGCA ACGGCAGCGT GGAGGACCGC TTCTCCGACG ACCAGCTCGT GTCCATGTCC
GTGCGCGAGC TGAACCGCCA CCTGCGGGGC TTCACCAAGG ACGAGGTGAT CCGCCTGAAG
CAGAAGCGGC GGACCCTGAA GAACCGGGGC TACGCCCAGT CTTGCAGGTA TAAACGCGTC
CAGCAGAAGC ACCACCTGGA GAATGAGAAG ACGCAGCTCA TTCAGCAGGT GGAGCAGCTT
AAGCAGGAGG TGTCCCGGCT GGCCCGCGAG AGAGACGCCT ACAAGGTCAA GTGCGAGAAA
CTCGCCAACT CCGGCTTCAG GGAGGCGGGC TCCACCAGCG ACAGCCCCTC CTCTCCCGAG
TTCTTTCTGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_005452.2
CDS391..1362
Misc Feature(1)64..66(+)
Misc Feature(2)628..732(+)
Misc Feature(3)1087..1296(+)
Misc Feature(4)1087..1296(+)
Misc Feature(5)1102..1179(+)
Misc Feature(6)1108..1167(+)
Misc Feature(7)1165..1284(+)
Misc Feature(8)1186..1251(+)
Exon (1)1..3393
Gene:MAFB
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_005461
Organism Homo sapiens (human)
Definition Homo sapiens v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005461

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGCCGCGG AGCTGAGCAT GGGGCCAGAG CTGCCCACCA GCCCGCTGGC CATGGAGTAT 
GTCAACGACT TCGACCTGCT CAAGTTCGAC GTGAAGAAGG AGCCACTGGG GCGCGCGGAG
CGTCCGGGCA GGCCCTGCAC ACGCCTGCAG CCAGCCGGCT CGGTGTCCTC CACACCGCTC
AGCACTCCGT GTAGCTCCGT GCCCTCGTCG CCCAGCTTCA GCCCGACCGA ACAGAAGACA
CACCTCGAGG ATCTGTACTG GATGGCGAGC AACTACCAGC AGATGAACCC CGAGGCGCTC
AACCTGACGC CCGAGGACGC GGTGGAAGCG CTCATCGGCT CGCACCCAGT GCCACAGCCG
CTGCAAAGCT TCGACAGCTT TCGCGGCGCT CACCACCACC ACCATCACCA CCACCCTCAC
CCGCACCACG CGTACCCGGG CGCCGGCGTG GCCCACGACG AGCTGGGCCC GCACGCTCAC
CCGCACCATC ACCATCATCA CCAAGCGTCG CCGCCGCCGT CCAGCGCCGC TAGCCCGGCG
CAACAGCTGC CCACTAGCCA CCCCGGGCCC GGGCCGCACG CGACGGCCTC GGCGACGGCG
GCGGGCGGCA ACGGCAGCGT GGAGGACCGC TTCTCCGACG ACCAGCTCGT GTCCATGTCC
GTGCGCGAGC TGAACCGCCA CCTGCGGGGC TTCACCAAGG ACGAGGTGAT CCGCCTGAAG
CAGAAGCGGC GGACCCTGAA GAACCGGGGC TACGCCCAGT CTTGCAGGTA TAAACGCGTC
CAGCAGAAGC ACCACCTGGA GAATGAGAAG ACGCAGCTCA TTCAGCAGGT GGAGCAGCTT
AAGCAGGAGG TGTCCCGGCT GGCCCGCGAG AGAGACGCCT ACAAGGTCAA GTGCGAGAAA
CTCGCCAACT CCGGCTTCAG GGAGGCGGGC TCCACCAGCG ACAGCCCCTC CTCTCCCGAG
TTCTTTCTGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

MafB is a downstream target of the IL-10/STAT3 signaling pathway, involved in the regulation of macrophage de-activation
Biochim. Biophys. Acta 1843 (5), 955-964 (2014)
Gemelli C, Zanocco Marani T, Bicciato S, Mazza EM, Boraschi D, Salsi V, Zappavigna V, Parenti S, Selmi T, Tagliafico E, Ferrari S and Grande A.


book

The identification of MAFB mutations in eight patients with multicentric carpo-tarsal osteolysis supports genetic homogeneity but clinical variability
Am. J. Med. Genet. A 161A (12), 3023-3029 (2013)
Mehawej C, Courcet JB, Baujat G, Mouy R, Gerard M, Landru I, Gosselin M, Koehrer P, Mousson C, Breton S, Quartier P, Le Merrer M, Faivre L and Cormier-Daire V.


book

Discovery and refinement of loci associated with lipid levels
Nat. Genet. 45 (11), 1274-1283 (2013)
Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A, Den Hertog HM, Do R, Donnelly LA, Ehret GB, Esko T, Feitosa MF, Ferreira T, Fischer K, Fontanillas P, Fraser RM, Freitag DF, Gurdasani D, Heikkila K, Hypponen E, Isaacs A, Jackson AU, Johansson A, Johnson T, Kaakinen M, Kettunen J, Kleber ME, Li X, Luan J, Lyytikainen LP, Magnusson PK, Mangino M, Mihailov E, Montasser ME, Muller-Nurasyid M, Nolte IM, O'Connell JR, Palmer CD, Perola M, Petersen AK, Sanna S, Saxena R, Service SK, Shah S, Shungin D, Sidore C, Song C, Strawbridge RJ, Surakka I, Tanaka T, Teslovich TM, Thorleifsson G, Van den Herik EG, Voight BF, Volcik KA, Waite LL, Wong A, Wu Y, Zhang W, Absher D, Asiki G, Barroso I, Been LF, Bolton JL, Bonnycastle LL, Brambilla P, Burnett MS, Cesana G, Dimitriou M, Doney AS, Doring A, Elliott P, Epstein SE, Eyjolfsson GI, Gigante B, Goodarzi MO, Grallert H, Gravito ML, Groves CJ, Hallmans G, Hartikainen AL, Hayward C, Hernandez D, Hicks AA, Holm H, Hung YJ, Illig T, Jones MR, Kaleebu P, Kastelein JJ, Khaw KT, Kim E, Klopp N, Komulainen P, Kumari M, Langenberg C, Lehtimaki T, Lin SY, Lindstrom J, Loos RJ, Mach F, McArdle WL, Meisinger C, Mitchell BD, Muller G, Nagaraja R, Narisu N, Nieminen TV, Nsubuga RN, Olafsson I, Ong KK, Palotie A, Papamarkou T, Pomilla C, Pouta A, Rader DJ, Reilly MP, Ridker PM, Rivadeneira F, Rudan I, Ruokonen A, Samani N, Scharnagl H, Seeley J, Silander K, Stancakova A, Stirrups K, Swift AJ, Tiret L, Uitterlinden AG, van Pelt LJ, Vedantam S, Wainwright N, Wijmenga C, Wild SH, Willemsen G, Wilsgaard T, Wilson JF, Young EH, Zhao JH, Adair LS, Arveiler D, Assimes TL, Bandinelli S, Bennett F, Bochud M, Boehm BO, Boomsma DI, Borecki IB, Bornstein SR, Bovet P, Burnier M, Campbell H, Chakravarti A, Chambers JC, Chen YD, Collins FS, Cooper RS, Danesh J, Dedoussis G, de Faire U, Feranil AB, Ferrieres J, Ferrucci L, Freimer NB, Gieger C, Groop LC, Gudnason V, Gyllensten U, Hamsten A, Harris TB, Hingorani A, Hirschhorn JN, Hofman A, Hovingh GK, Hsiung CA, Humphries SE, Hunt SC, Hveem K, Iribarren C, Jarvelin MR, Jula A, Kahonen M, Kaprio J, Kesaniemi A, Kivimaki M, Kooner JS, Koudstaal PJ, Krauss RM, Kuh D, Kuusisto J, Kyvik KO, Laakso M, Lakka TA, Lind L, Lindgren CM, Martin NG, Marz W, McCarthy MI, McKenzie CA, Meneton P, Metspalu A, Moilanen L, Morris AD, Munroe PB, Njolstad I, Pedersen NL, Power C, Pramstaller PP, Price JF, Psaty BM, Quertermous T, Rauramaa R, Saleheen D, Salomaa V, Sanghera DK, Saramies J, Schwarz PE, Sheu WH, Shuldiner AR, Siegbahn A, Spector TD, Stefansson K, Strachan DP, Tayo BO, Tremoli E, Tuomilehto J, Uusitupa M, van Duijn CM, Vollenweider P, Wallentin L, Wareham NJ, Whitfield JB, Wolffenbuttel BH, Ordovas JM, Boerwinkle E, Palmer CN, Thorsteinsdottir U, Chasman DI, Rotter JI, Franks PW, Ripatti S, Cupples LA, Sandhu MS, Rich SS, Boehnke M, Deloukas P, Kathiresan S, Mohlke KL, Ingelsson E and Abecasis GR.


book

Inactivation of specific beta cell transcription factors in type 2 diabetes
J. Clin. Invest. 123 (8), 3305-3316 (2013)
Guo,S., Dai,C., Guo,M., Taylor,B., Harmon,J.S., Sander,M., Robertson,R.P., Powers,A.C. and Stein,R.


book

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population
PLoS ONE 7 (12), E51954 (2012)
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA and Butte NF.


book

An autosomal dominant posterior polar cataract locus maps to human chromosome 20p12-q12
Eur. J. Hum. Genet. 8 (7), 535-539 (2000)
Yamada K, Tomita H, Yoshiura K, Kondo S, Wakui K, Fukushima Y, Ikegawa S, Nakamura Y, Amemiya T and Niikawa N.


book

EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes
Oncogene 19 (6), 745-753 (2000)
Li R, Pei H, Watson DK and Papas TS.


book

Human KRML (MAFB): cDNA cloning, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias
Genomics 59 (3), 275-281 (1999)
Wang PW, Eisenbart JD, Cordes SP, Barsh GS, Stoffel M and Le Beau MM.


book

A yeast artificial chromosome-based map of the region of chromosome 20 containing the diabetes-susceptibility gene, MODY1, and a myeloid leukemia related gene
Proc. Natl. Acad. Sci. U.S.A. 93 (9), 3937-3941 (1996)
Stoffel M, Le Beau MM, Espinosa R 3rd, Bohlander SF, Le Paslier D, Cohen D, Xiang KS, Cox NJ, Fajans SS and Bell GI.


book

MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation
Cell 85 (1), 49-60 (1996)
Sieweke MH, Tekotte H, Frampton J and Graf T.


 
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