||ORF Nucleotide Sequence (Length: 525bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||RNA-binding protein 8A
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB286556.1, AF127761.1,
AC243547.1 and AI424454.1.
On Jul 19, 2013 this sequence version replaced gi:324120942.
Summary: This gene encodes a protein with a conserved RNA-binding
motif. The protein is found predominantly in the nucleus, although
it is also present in the cytoplasm. It is preferentially
associated with mRNAs produced by splicing, including both nuclear
mRNAs and newly exported cytoplasmic mRNAs. It is thought that the
protein remains associated with spliced mRNAs as a tag to indicate
where introns had been present, thus coupling pre- and post-mRNA
splicing events. Previously, it was thought that two genes encode
this protein, RBM8A and RBM8B; it is now thought that the RBM8B
locus is a pseudogene. There are two alternate translation start
codons with this gene, which result in two forms of the protein. An
allele mutation and a low-frequency noncoding single-nucleotide
polymorphism (SNP) in this gene cause thrombocytopenia-absent
radius (TAR) syndrome. [provided by RefSeq, Jul 2013].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: BC071577.1, AK075009.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.