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RBM8A RNA binding motif protein 8A [Homo sapiens (human)]

Gene Symbol RBM8A
Entrez Gene ID 9939
Full Name RNA binding motif protein 8A
Synonyms BOV-1A, BOV-1B, BOV-1C, C1DELq21.1, DEL1q21.1, MDS014, RBM8, RBM8B, TAR, Y14, ZNRP, ZRNP1
General protein information
Preferred Names
RNA-binding protein 8A
Names
RNA-binding protein 8A
BOV-1
binder of OVCA1-1
ribonucleoprotein RBM8
RNA-binding protein Y14
ribonucleoprotein RBM8A
RNA binding motif protein 8B
RNA-binding motif protein 8A
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q21.1

Summary This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. There are two alternate translation start codons with this gene, which result in two forms of the protein. An allele mutation and a low-frequency noncoding single-nucleotide polymorphism (SNP) in this gene cause thrombocytopenia-absent radius (TAR) syndrome. [provided by RefSeq, Jul 2013]. lac of sum
Disorder MIM:

605313

Disorder Html:
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu20462 NM_005105 Homo sapiens RNA binding motif protein 8A (RBM8A), mRNA. pcDNA3.1-C-(k)DYK In stock 5-7 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu20462D
Sequence Information ORF Nucleotide Sequence (Length: 525bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product RNA-binding protein 8A
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB286556.1, AF127761.1, AC243547.1 and AI424454.1. On Jul 19, 2013 this sequence version replaced gi:324120942. Summary: This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. There are two alternate translation start codons with this gene, which result in two forms of the protein. An allele mutation and a low-frequency noncoding single-nucleotide polymorphism (SNP) in this gene cause thrombocytopenia-absent radius (TAR) syndrome. [provided by RefSeq, Jul 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC071577.1, AK075009.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA962337, SAMEA962343 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

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ATGGCGGACG TGCTAGATCT TCACGAGGCT GGGGGCGAAG ATTTCGCCAT GGATGAGGAT 
GGGGACGAGA GCATTCACAA ACTGAAAGAA AAAGCGAAGA AACGGAAGGG TCGCGGCTTT
GGCTCCGAAG AGGGGTCCCG AGCGCGGATG CGTGAGGATT ATGACAGCGT GGAGCAGGAT
GGCGATGAAC CCGGACCACA ACGCTCTGTT GAAGGCTGGA TTCTCTTTGT AACTGGAGTC
CATGAGGAAG CCACCGAAGA AGACATACAC GACAAATTCG CAGAATATGG GGAAATTAAA
AACATTCATC TCAACCTCGA CAGGCGAACA GGATATCTGA AGGGGTATAC TCTAGTTGAA
TATGAAACAT ACAAGGAAGC CCAGGCTGCT ATGGAGGGAC TCAATGGCCA GGATTTGATG
GGACAGCCCA TCAGCGTTGA CTGGTGTTTT GTTCGGGGTC CACCAAAAGG CAAGAGGAGA
GGTGGCCGAA GACGCAGCAG AAGTCCAGAC CGGAGACGTC GCTGA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_005096.1
CDS111..635
Misc Feature(1)69..71(+)
Misc Feature(2)114..116(+)
Misc Feature(3)180..182(+)
Misc Feature(4)234..236(+)
Misc Feature(5)234..236(+)
Misc Feature(6)246..248(+)
Misc Feature(7)276..278(+)
Misc Feature(8)309..563(+)
Misc Feature(9)309..563(+)
Misc Feature(10)333..548(+)
Misc Feature(11)606..608(+)
Misc Feature(12)612..614(+)
Misc Feature(13)159..161(+)
Exon (1)1..177
Gene:RBM8A
Gene Synonym:
Exon (2)178..237
Gene:RBM8A
Gene Synonym:
Exon (3)238..315
Gene:RBM8A
Gene Synonym:
Exon (4)316..452
Gene:RBM8A
Gene Synonym:
Exon (5)453..589
Gene:RBM8A
Gene Synonym:
Exon (6)590..4961
Gene:RBM8A
Gene Synonym:
Translation
Position Chain Variation Link
20 20 c, t dbSNP:780557935
32 32 a, g dbSNP:749627834
50 50 a, g dbSNP:58332842
74 74 a, t dbSNP:768998134
90 90 a, g, t dbSNP:139428292
92 92 a, g, t dbSNP:760383043
176 176 c, t dbSNP:770606575
317 317 -, agcg dbSNP:397515388
597 597 c, t dbSNP:397515389
641 641 c, g, t dbSNP:12079762
736 736 c, t dbSNP:1048870
743 743 c, t dbSNP:55781003
744 744 a, c, g dbSNP:113989026
827 827 a, t dbSNP:55897390
888 888 -, t dbSNP:376280551
1487 1487 a, c dbSNP:3768298
1800 1800 a, g dbSNP:1058534
2186 2186 a, g dbSNP:757436429
2324 2324 g, t dbSNP:199817292
2415 2415 c, t dbSNP:750487684
2959 2959 c, g dbSNP:117371762
3220 3220 g, t dbSNP:72701871
3222 3222 g, t dbSNP:199958689
3223 3223 g, t dbSNP:201225488
3227 3227 g, t dbSNP:202122090
3299 3299 a, g dbSNP:780428911
3341 3341 c, t dbSNP:749795633
3373 3373 a, g dbSNP:768957907
3588 3588 a, t dbSNP:80094349
3755 3755 a, g dbSNP:76363180
3756 3756 g, t dbSNP:74959119
3868 3868 a, g dbSNP:779392048
4032 4032 c, t dbSNP:748486064
4138 4138 c, t dbSNP:112979084
4277 4277 c, t dbSNP:776365815
4826 4826 -, c dbSNP:769345991
4907 4907 c, t dbSNP:77198650

Target ORF information:

RefSeq Version NM_005105
Organism Homo sapiens (human)
Definition Homo sapiens RNA binding motif protein 8A (RBM8A), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_005105

ORF Insert Sequence:

1
61
121
181
241
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361
421
481
ATGGCGGACG TGCTAGATCT TCACGAGGCT GGGGGCGAAG ATTTCGCCAT GGATGAGGAT 
GGGGACGAGA GCATTCACAA ACTGAAAGAA AAAGCGAAGA AACGGAAGGG TCGCGGCTTT
GGCTCCGAAG AGGGGTCCCG AGCGCGGATG CGTGAGGATT ATGACAGCGT GGAGCAGGAT
GGCGATGAAC CCGGACCACA ACGCTCTGTT GAAGGCTGGA TTCTCTTTGT AACTGGAGTC
CATGAGGAAG CCACCGAAGA AGACATACAC GACAAATTCG CAGAATATGG GGAAATTAAA
AACATTCATC TCAACCTCGA CAGGCGAACA GGATATCTGA AGGGGTATAC TCTAGTTGAA
TATGAAACAT ACAAGGAAGC CCAGGCTGCT ATGGAGGGAC TCAATGGCCA GGATTTGATG
GGACAGCCCA TCAGCGTTGA CTGGTGTTTT GTTCGGGGTC CACCAAAAGG CAAGAGGAGA
GGTGGCCGAA GACGCAGCAG AAGTCCAGAC CGGAGACGTC GCTGA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.