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KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 [Homo sapiens (human)]

Gene Symbol KCNE2
Entrez Gene ID 9992
Full Name potassium channel, voltage gated subfamily E regulatory beta subunit 2
Synonyms ATFB4, LQT5, LQT6, MIRP1
General protein information
Preferred Names
potassium voltage-gated channel subfamily E member 2
Names
potassium voltage-gated channel subfamily E member 2
minK-related peptide 1
minK-related peptide-1
potassium channel subunit, MiRP1
potassium channel subunit beta MiRP1
voltage-gated K+ channel subunit MIRP1
minimum potassium ion channel-related peptide 1
cardiac voltage-gated potassium channel accessory subunit 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

21

21q22.12

Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

603796

Disorder Html: Long QT syndrome-6, 613693 (3); Atrial fibrillation, familial, 4,





The following KCNE2 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNE2 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu25916 NM_172201 Homo sapiens potassium voltage-gated channel, Isk-related family, member 2 (KCNE2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$69.3
$99

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**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu25916
Accession Version NM_172201.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 372bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product potassium voltage-gated channel subfamily E member 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF302095.1. This sequence is a reference standard in the RefSeqGene project. Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF302095.1, BC112087.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
ATGTCTACTT TATCCAATTT CACACAGACG CTGGAAGACG TCTTCCGAAG GATTTTTATT 
ACTTATATGG ACAATTGGCG CCAGAACACA ACAGCTGAGC AAGAGGCCCT CCAAGCCAAA
GTTGATGCTG AGAACTTCTA CTATGTCATC CTGTACCTCA TGGTGATGAT TGGAATGTTC
TCTTTCATCA TCGTGGCCAT CCTGGTGAGC ACTGTGAAAT CCAAGAGACG GGAACACTCC
AATGACCCCT ACCACCAGTA CATTGTAGAG GACTGGCAGG AAAAGTACAA GAGCCAAATC
TTGAATCTAG AAGAATCGAA GGCCACCATC CATGAGAACA TTGGTGCGGC TGGGTTCAAA
ATGTCCCCCT GA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_751951.1
CDS141..512
Misc Feature(1)126..128(+)
Misc Feature(2)285..347(+)
Misc Feature(3)291..464(+)
Exon (1)1..128
Gene:KCNE2
Gene Synonym:
Exon (2)129..803
Gene:KCNE2
Gene Synonym:
Translation
Position Chain Variation Link
20 20 c, t dbSNP:188625398
56 56 a, g dbSNP:41315511
61 61 c, t dbSNP:566735365
62 62 a, g dbSNP:41260744
89 89 a, g dbSNP:41314699
111 111 c, t dbSNP:72550226
122 122 a, t dbSNP:759027023
140 140 c, t dbSNP:757838648
157 157 a, g dbSNP:776661633
162 162 a, g dbSNP:2234916
163 163 c, t dbSNP:35759083
165 165 c, g dbSNP:16991652
166 166 a, g dbSNP:758038035
169 169 c, t dbSNP:199473648
170 170 a, g dbSNP:751014874
176 176 a, c dbSNP:754523450
179 179 c, t dbSNP:556106127
180 180 a, g dbSNP:142153692
184 184 c, t dbSNP:374431902
186 186 c, t dbSNP:779306606
187 187 a, g dbSNP:368865412
193 193 -, t dbSNP:762880940
199 199 a, t dbSNP:199473363
203 203 c, t dbSNP:138954752
206 206 c, t dbSNP:775857492
207 207 a, t dbSNP:747045005
215 215 c, t dbSNP:372013275
219 219 c, t dbSNP:74315449
220 220 a, g dbSNP:148968498
222 222 c, t dbSNP:369159493
229 229 a, c dbSNP:772975913
232 232 c, g, t dbSNP:757208768
249 249 c, t dbSNP:765952344
251 251 c, t dbSNP:751248501
252 252 c, g dbSNP:554011844
256 256 c, g dbSNP:767031659
259 259 a, g dbSNP:752190819
278 278 -, a dbSNP:763797654
280 280 a, c dbSNP:757779830
281 281 a, c, t dbSNP:779623946
283 283 -, t dbSNP:751276927
283 283 a, c dbSNP:758863768
284 284 g, t dbSNP:780373385
290 290 c, t dbSNP:747232176
293 293 g, t dbSNP:143767851
296 296 c, t dbSNP:776764531
300 300 -, tgg dbSNP:756730160
300 300 a, g dbSNP:371724328
301 301 c, t dbSNP:74315447
306 306 a, g dbSNP:199473649
310 310 c, t dbSNP:74315448
311 311 g, t dbSNP:146053586
315 315 a, c, g dbSNP:770739581
318 318 a, c, t dbSNP:16991654
332 332 c, t dbSNP:767142542
333 333 a, c, g dbSNP:199473364
335 335 g, t dbSNP:765797117
336 336 a, g dbSNP:745605145
337 337 c, t dbSNP:16991656
344 344 a, g dbSNP:200403369
345 345 a, g dbSNP:542835031
347 347 a, g dbSNP:780534713
349 349 a, g dbSNP:751931568
362 362 c, t dbSNP:755211128
366 366 a, c dbSNP:138831412
367 367 a, g dbSNP:748194563
368 368 a, g dbSNP:202169020
369 369 c, t dbSNP:141423405
370 370 a, g dbSNP:199473365
376 376 a, c dbSNP:770895197
386 386 c, t dbSNP:774193019
389 389 c, t dbSNP:778998757
401 401 c, t dbSNP:587781005
402 402 a, c dbSNP:771699510
404 404 c, t dbSNP:775034771
409 409 a, g dbSNP:199473366
418 418 a, g dbSNP:760181970
421 421 a, g dbSNP:74424227
436 436 -, a dbSNP:780568059
441 441 c, t dbSNP:753438833
443 443 a, g dbSNP:763545106
444 444 a, t dbSNP:767047359
448 448 c, t dbSNP:751891377
451 451 a, g dbSNP:113659353
457 457 c, t dbSNP:183427173
458 458 a, g dbSNP:781438592
472 472 a, g dbSNP:752888066
479 479 a, c dbSNP:756380802
486 486 a, g dbSNP:150790888
487 487 c, t dbSNP:199473367
488 488 a, g dbSNP:16991657
490 490 c, t dbSNP:376886316
492 492 a, g dbSNP:745612699
492 492 -, g dbSNP:750011503
494 494 a, g dbSNP:187917779
497 497 a, c dbSNP:139202426
502 502 a, t dbSNP:786205807
504 504 -, c dbSNP:756561888
507 507 c, t dbSNP:746625998
509 509 -, ct dbSNP:45610936
511 511 c, g dbSNP:786205808
523 523 a, c dbSNP:558860396
525 525 a, g dbSNP:776266940
527 527 a, g dbSNP:761420303
529 529 c, t dbSNP:374093618
534 534 -, aac dbSNP:749615979
541 541 g, t dbSNP:766924678
544 544 c, t dbSNP:72550217
545 545 a, g dbSNP:193181183
548 548 c, t dbSNP:201388192
558 558 g, t dbSNP:375557746
571 571 a, c dbSNP:751463321
573 573 c, t dbSNP:551483595
574 574 a, g dbSNP:72550218
626 626 a, g dbSNP:72550219
650 650 a, g dbSNP:537049622
666 666 a, g dbSNP:527911136
720 720 c, t dbSNP:549554314
752 752 c, g dbSNP:773295544
787 787 c, t dbSNP:140393558
795 795 a, g dbSNP:531397232

Target ORF information:

RefSeq Version NM_172201
Organism Homo sapiens (human)
Definition Homo sapiens potassium voltage-gated channel, Isk-related family, member 2 (KCNE2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_172201

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGTCTACTT TATCCAATTT CACACAGACG CTGGAAGACG TCTTCCGAAG GATTTTTATT 
ACTTATATGG ACAATTGGCG CCAGAACACA ACAGCTGAGC AAGAGGCCCT CCAAGCCAAA
GTTGATGCTG AGAACTTCTA CTATGTCATC CTGTACCTCA TGGTGATGAT TGGAATGTTC
TCTTTCATCA TCGTGGCCAT CCTGGTGAGC ACTGTGAAAT CCAAGAGACG GGAACACTCC
AATGACCCCT ACCACCAGTA CATTGTAGAG GACTGGCAGG AAAAGTACAA GAGCCAAATC
TTGAATCTAG AAGAATCGAA GGCCACCATC CATGAGAACA TTGGTGCGGC TGGGTTCAAA
ATGTCCCCCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.