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Il10 cDNA ORF clone, Mus musculus (house mouse)

Gene Symbol Il10
Entrez Gene ID 16153
Full Name interleukin 10
Synonyms CSIF, Il-10
General protein information
Preferred Names
interleukin-10
Names
interleukin-10
cytokine synthesis inhibitory factor
Gene Type protein-coding
Organism Mus musculus (house mouse)
Genome

1

1 E4|1 56.89 cM

Summary lac of sum

mRNA and Protein(s)

mRNA Protein Name
NM_010548 NP_034678 interleukin-10 precursor



Homo sapiens (human) IL10 NP_000563.1
Pan troglodytes (chimpanzee) IL10 NP_001129092.2
Macaca mulatta (Rhesus monkey) IL10 NP_001038192.1
Canis lupus familiaris (dog) IL10 NP_001003077.1
Bos taurus (cattle) IL10 NP_776513.1
Mus musculus (house mouse) Il10 NP_034678.1
Rattus norvegicus (Norway rat) Il10 NP_036986.2
Gallus gallus (chicken) IL10 NP_001004414.2
Danio rerio (zebrafish) il10 NP_001018621.2
Xenopus (Silurana) tropicalis (western clawed frog) il10 NP_001165400.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

The following Il10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Il10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OMu22605
NM_010548 Mus musculus interleukin 10 (Il10), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OMu22605
Clone ID Related Accession (Same CDS sequence) NM_010548
Accession Version NM_010548.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 537bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-FEB-2015
Organism Mus musculus (house mouse)
Product interleukin-10 precursor
Comment VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK152344.1 and M37897.1. On Mar 26, 2010 this sequence version replaced gi:6754317. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK152344.1, BC120612.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164133, SAMN01164134 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
ATGCCTGGCT CAGCACTGCT ATGCTGCCTG CTCTTACTGA CTGGCATGAG GATCAGCAGG 
GGCCAGTACA GCCGGGAAGA CAATAACTGC ACCCACTTCC CAGTCGGCCA GAGCCACATG
CTCCTAGAGC TGCGGACTGC CTTCAGCCAG GTGAAGACTT TCTTTCAAAC AAAGGACCAG
CTGGACAACA TACTGCTAAC CGACTCCTTA ATGCAGGACT TTAAGGGTTA CTTGGGTTGC
CAAGCCTTAT CGGAAATGAT CCAGTTTTAC CTGGTAGAAG TGATGCCCCA GGCAGAGAAG
CATGGCCCAG AAATCAAGGA GCATTTGAAT TCCCTGGGTG AGAAGCTGAA GACCCTCAGG
ATGCGGCTGA GGCGCTGTCA TCGATTTCTC CCCTGTGAAA ATAAGAGCAA GGCAGTGGAG
CAGGTGAAGA GTGATTTTAA TAAGCTCCAA GACCAAGGTG TCTACAAGGC CATGAATGAA
TTTGACATCT TCATCAACTG CATAGAAGCA TACATGATGA TCAAAATGAA AAGCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_034678.1
CDS68..604
Misc Feature(1)110..589(+)
Exon (1)1..232
Gene:Il10
Gene Synonym:
Exon (2)233..292
Gene:Il10
Gene Synonym:
Exon (3)293..445
Gene:Il10
Gene Synonym:
Exon (4)446..511
Gene:Il10
Gene Synonym:
Exon (5)512..1306
Gene:Il10
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_010548
Organism Mus musculus (house mouse)
Definition Mus musculus interleukin 10 (Il10), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_010548

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGCCTGGCT CAGCACTGCT ATGCTGCCTG CTCTTACTGA CTGGCATGAG GATCAGCAGG 
GGCCAGTACA GCCGGGAAGA CAATAACTGC ACCCACTTCC CAGTCGGCCA GAGCCACATG
CTCCTAGAGC TGCGGACTGC CTTCAGCCAG GTGAAGACTT TCTTTCAAAC AAAGGACCAG
CTGGACAACA TACTGCTAAC CGACTCCTTA ATGCAGGACT TTAAGGGTTA CTTGGGTTGC
CAAGCCTTAT CGGAAATGAT CCAGTTTTAC CTGGTAGAAG TGATGCCCCA GGCAGAGAAG
CATGGCCCAG AAATCAAGGA GCATTTGAAT TCCCTGGGTG AGAAGCTGAA GACCCTCAGG
ATGCGGCTGA GGCGCTGTCA TCGATTTCTC CCCTGTGAAA ATAAGAGCAA GGCAGTGGAG
CAGGTGAAGA GTGATTTTAA TAAGCTCCAA GACCAAGGTG TCTACAAGGC CATGAATGAA
TTTGACATCT TCATCAACTG CATAGAAGCA TACATGATGA TCAAAATGAA AAGCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Induction of TGF-beta and IL-10 production in dendritic cells using astilbin to inhibit dextran sulfate sodium-induced colitis
Biochem. Biophys. Res. Commun. 446 (2), 529-534 (2014)
Ding Y, Liang Y, Deng B, Qiao A, Wu K, Xiao W and Gong W.


book

Preferential production of IgG1, IL-4 and IL-10 in MuSK-immunized mice
Clin. Immunol. 151 (2), 155-163 (2014)
Ulusoy C, Kim E, Tuzun E, Huda R, Yilmaz V, Poulas K, Trakas N, Skriapa L, Niarchos A, Strait RT, Finkelman FD, Turan S, Zisimopoulou P, Tzartos S, Saruhan-Direskeneli G and Christadoss P.


book

S100A8 induces IL-10 and protects against acute lung injury
J. Immunol. 192 (6), 2800-2811 (2014)
Hiroshima Y, Hsu K, Tedla N, Chung YM, Chow S, Herbert C and Geczy CL.


book

Protection against collagen-induced arthritis in mice afforded by the parasitic worm product, ES-62, is associated with restoration of the levels of interleukin-10-producing B cells and reduced plasma cell infiltration of the joints
Immunology 141 (3), 457-466 (2014)
Rodgers DT, Pineda MA, McGrath MA, Al-Riyami L, Harnett W and Harnett MM.


book

[Pseudomonas aeruginosa recombinant proteins: effect on mice cytokine profile]
Zh. Mikrobiol. Epidemiol. Immunobiol. 6, 80-87 (2013)
Soldatenkova,A.V., Geiderova,L.A., Akhmatova,N.K. and Mikhailova,N.A.


book

IL-10 induces transcription of the gene for mouse mast cell protease-1, a serine protease preferentially expressed in mucosal mast cells of Trichinella spiralis-infected mice
J. Immunol. 149 (6), 2123-2129 (1992)
Ghildyal N, McNeil HP, Stechschulte S, Austen KF, Silberstein D, Gurish MF, Somerville LL and Stevens RL.


book

Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes
J. Immunol. 148 (11), 3618-3623 (1992)
Kim JM, Brannan CI, Copeland NG, Jenkins NA, Khan TA and Moore KW.


book

Interleukins 9, 10, 11 and 12 and kit ligand: a brief overview
Res. Immunol. 143 (4), 385-400 (1992)
Quesniaux VF.


book

Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI
Proc. Natl. Acad. Sci. U.S.A. 88 (4), 1172-1176 (1991)
Vieira P, de Waal-Malefyt R, Dang MN, Johnson KE, Kastelein R, Fiorentino DF, deVries JE, Roncarolo MG, Mosmann TR and Moore KW.


book

Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI
Science 248 (4960), 1230-1234 (1990)
Moore KW, Vieira P, Fiorentino DF, Trounstine ML, Khan TA and Mosmann TR.


 
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