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Il7r cDNA ORF clone, Mus musculus (house mouse)

Gene Symbol Il7r
Entrez Gene ID 16197
Full Name interleukin 7 receptor
Synonyms CD127, IL-7Ralpha
General protein information
Preferred Names
interleukin-7 receptor subunit alpha
Names
interleukin-7 receptor subunit alpha
IL-7RA
IL-7R-alpha
IL-7R subunit alpha
IL-7 receptor alpha chain
IL-7 receptor subunit alpha
interleukin 7 receptor alpha chain
Gene Type protein-coding
Organism Mus musculus (house mouse)
Genome

15

15 A1|15 4.16 cM

Summary Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

Disorder Html:

mRNA and Protein(s)

mRNA Protein Name
NM_008372 NP_032398 interleukin-7 receptor subunit alpha precursor

KEGG
mmu04060 Cytokine-cytokine receptor interaction
mmu04630 Jak-STAT signaling pathway
mmu04640 Hematopoietic cell lineage
mmu05340 Primary immunodeficiency
mmu04151 PI3K-Akt signaling pathway
mmu04068 FoxO signaling pathway
WikiPathways
WP297 IL-7 Signaling Pathway
WP2309 XPodNet - protein-protein interactions in the podocyte expanded by STRING


Homo sapiens (human) IL7R NP_002176.2
Pan troglodytes (chimpanzee) IL7R XP_517807.2
Macaca mulatta (Rhesus monkey) IL7R XP_001092582.1
Canis lupus familiaris (dog) IL7R XP_855408.1
Bos taurus (cattle) IL7R NP_001192816.1
Mus musculus (house mouse) Il7r NP_032398.3
Rattus norvegicus (Norway rat) Il7r NP_001099888.1
Gallus gallus (chicken) IL7R NP_001073575.1

Component

ID Name Evidence
GO:0009897 external side of plasma membrane IDA
GO:0016020 membrane IEA
GO:0016021 integral to membrane IEA

Function

ID Name Evidence
GO:0004872 receptor activity IEA
GO:0004896 cytokine receptor activity IEA

Process

ID Name Evidence
GO:0000902 cell morphogenesis IGI
GO:0001915 negative regulation of T cell mediated cytotoxicity IMP
GO:0002377 immunoglobulin production IGI
GO:0008361 regulation of cell size IDA
GO:0008361 regulation of cell size IGI
GO:0010628 positive regulation of gene expression IMP
GO:0016049 cell growth IMP
GO:0030217 T cell differentiation IMP
GO:0033089 positive regulation of T cell differentiation in thymus IMP
GO:0042100 B cell proliferation IGI
GO:0042100 B cell proliferation IMP
GO:0048535 lymph node development IMP
GO:0048872 homeostasis of number of cells IGI
GO:0048872 homeostasis of number of cells IMP

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

The following Il7r gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Il7r cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OMu22595 NM_008372 Mus musculus interleukin 7 receptor (Il7r), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $319.00

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OMu22595
Accession Version NM_008372.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1380bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-FEB-2015
Organism Mus musculus (house mouse)
Product interleukin-7 receptor subunit alpha precursor
Comment VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY776757.1, AK040364.1, AK042264.1 and BC089571.1. On Feb 22, 2008 this sequence version replaced gi:45269151. Summary: Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M29697.1, AK042264.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849383 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGATGGCTC TGGGTAGAGC TTTCGCTATA GTTTTCTGCT TAATTCAAGC TGTTTCTGGA 
GAAAGTGGAA ATGCCCAGGA TGGAGACCTA GAAGATGCAG ACGCGGACGA TCACTCCTTC
TGGTGCCACA GCCAGTTGGA AGTGGATGGA AGTCAACATT TATTGACTTG TGCTTTTAAT
GACTCAGACA TCAACACAGC TAATCTGGAA TTTCAAATAT GTGGGGCTCT TTTACGAGTG
AAATGCCTAA CTCTTAACAA GCTGCAAGAT ATATATTTTA TAAAGACATC AGAATTCTTA
CTGATTGGTA GCAGCAATAT ATGTGTGAAG CTTGGACAAA AGAATTTAAC TTGCAAAAAT
ATGGCTATAA ACACAATAGT TAAAGCCGAG GCTCCCTCTG ACCTGAAAGT CGTTTATCGC
AAAGAAGCAA ATGATTTTTT GGTGACATTT AATGCACCTC ACTTGAAAAA GAAATATTTA
AAAAAAGTAA AGCATGATGT GGCCTACCGC CCAGCAAGGG GTGAAAGCAA CTGGACGCAT
GTATCTTTAT TCCACACAAG AACAACAATC CCACAGAGAA AACTACGACC AAAAGCAATG
TATGAAATCA AAGTCCGATC CATTCCCCAT AACGATTACT TCAAAGGCTT CTGGAGCGAG
TGGAGTCCAA GTTCTACCTT CGAAACTCCA GAACCCAAGA ATCAAGGAGG ATGGGATCCT
GTCTTGCCAA GTGTCACCAT TCTGAGTTTG TTCTCTGTGT TTTTGTTGGT CATCTTAGCC
CATGTGCTAT GGAAAAAAAG GATTAAACCT GTCGTATGGC CTAGTCTCCC CGATCATAAG
AAAACTCTGG AACAACTATG TAAGAAGCCA AAAACGAGTC TGAATGTGAG TTTCAATCCC
GAAAGTTTCC TGGACTGCCA GATTCATGAG GTGAAAGGCG TTGAAGCCAG GGACGAGGTG
GAAAGTTTTC TGCCCAATGA TCTTCCTGCA CAGCCAGAGG AGTTGGAGAC ACAGGGACAC
AGAGCCGCTG TACACAGTGC AAACCGCTCG CCTGAGACTT CAGTCAGCCC ACCAGAAACA
GTTAGAAGAG AGTCACCCTT AAGATGCCTG GCTAGAAATC TGAGTACCTG CAATGCCCCT
CCACTCCTTT CCTCTAGGTC CCCTGACTAC AGAGATGGTG ACAGAAATAG GCCTCCTGTG
TATCAAGACT TGCTGCCAAA CTCTGGAAAC ACAAATGTCC CTGTCCCTGT CCCTCAACCA
TTGCCTTTCC AGTCGGGAAT CCTGATACCA GTTTCTCAGA GACAGCCCAT CTCCACTTCC
TCAGTACTGA ATCAAGAAGA AGCGTATGTC ACCATGTCTA GTTTTTACCA AAACAAATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_032398.3
CDS135..1514
Misc Feature(1)522..821(+)
Misc Feature(2)723..785(+)
Misc Feature(3)786..800(+)
Misc Feature(4)786..800(+)
Misc Feature(5)852..926(+)
Misc Feature(6)948..974(+)
Exon (1)1..216
Gene:Il7r
Gene Synonym:
Exon (2)217..355
Gene:Il7r
Gene Synonym:
Exon (3)356..513
Gene:Il7r
Gene Synonym:
Exon (4)514..671
Gene:Il7r
Gene Synonym:
Exon (5)672..840
Gene:Il7r
Gene Synonym:
Exon (6)841..934
Gene:Il7r
Gene Synonym:
Exon (7)935..1010
Gene:Il7r
Gene Synonym:
Exon (8)1011..3210
Gene:Il7r
Gene Synonym:
Translation
Position Chain Variation Link
11 11 a, t dbSNP:32718331
41 41 c, t dbSNP:243146429
59 59 a, g dbSNP:32718332
82 82 a, c dbSNP:258367543
87 87 -, ttctctctctctctctctctctctctctct dbSNP:236268799
113 113 -, c dbSNP:260672730
115 115 -, c dbSNP:251181942
131 131 -, tctc dbSNP:218836298
203 203 a, c dbSNP:32718333
236 236 c, t dbSNP:32720742
242 242 c, t dbSNP:225068548
515 515 a, t dbSNP:3667918
545 545 c, t dbSNP:52145800
569 569 c, t dbSNP:48765930
852 852 c, g dbSNP:48611234
857 857 c, t dbSNP:51419916
860 860 a, g dbSNP:255085936
1012 1012 a, g dbSNP:234128119
1013 1013 c, t dbSNP:46973526
1074 1074 a, g dbSNP:245213169
1088 1088 c, t dbSNP:227662131
1109 1109 a, c dbSNP:262396114
1112 1112 c, t dbSNP:256533143
1127 1127 a, g dbSNP:227882416
1130 1130 a, c dbSNP:264945218
1137 1137 c, t dbSNP:52062004
1161 1161 a, g dbSNP:223678740
1185 1185 c, t dbSNP:259507296
1201 1201 a, g dbSNP:241578849
1215 1215 g, t dbSNP:224822334
1327 1327 c, t dbSNP:48439207
1383 1383 -, gtccct dbSNP:252596773
1537 1537 a, g dbSNP:238879951
1592 1592 c, t dbSNP:220100142
1612 1612 c, t dbSNP:248660898
1794 1794 a, g dbSNP:234192319
1812 1812 c, t dbSNP:52311072
1882 1882 c, t dbSNP:245266406
1926 1926 a, g dbSNP:238644018
1995 1995 a, g dbSNP:214332117
2015 2015 c, t dbSNP:46532487
2121 2121 a, c dbSNP:51644553
2133 2133 a, g dbSNP:228211066
2153 2153 g, t dbSNP:262038678
2160 2160 -, ttaa dbSNP:219016334
2160 2160 a, c, t dbSNP:248148439
2261 2261 c, t dbSNP:47833073
2310 2310 a, g dbSNP:259372754
2316 2316 a, g dbSNP:241645245
2317 2317 -, a dbSNP:248472574
2318 2318 -, ag dbSNP:265803157
2347 2347 -, gtt dbSNP:237769771
2380 2380 a, g dbSNP:31767571
2415 2415 a, g dbSNP:265376237
2511 2511 a, g dbSNP:50776044
2529 2529 -, agtcctcctatgtg dbSNP:224839073
2580 2580 c, t dbSNP:219653948
2615 2615 a, g dbSNP:248713932
2616 2616 c, t dbSNP:240590152
2617 2617 a, g dbSNP:48858472
2637 2637 c, t dbSNP:251109566
2658 2658 a, g dbSNP:241087029
2720 2720 a, g dbSNP:213733047
2781 2781 a, g dbSNP:262416361
2796 2796 c, t dbSNP:234770436
2865 2865 c, t dbSNP:48351901
3023 3023 a, g dbSNP:248207850
3029 3029 g, t dbSNP:229375000
3052 3052 a, g dbSNP:215486983
3055 3055 a, c dbSNP:253424027
3143 3143 c, g dbSNP:230490994
3147 3147 a, g dbSNP:262969858
3175 3175 c, t dbSNP:244457716
3193 3193 a, g dbSNP:227312665
3196 3196 c, g dbSNP:52343824

Target ORF information:

RefSeq Version NM_008372
Organism Mus musculus (house mouse)
Definition Mus musculus interleukin 7 receptor (Il7r), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_008372

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGATGGCTC TGGGTAGAGC TTTCGCTATA GTTTTCTGCT TAATTCAAGC TGTTTCTGGA 
GAAAGTGGAA ATGCCCAGGA TGGAGACCTA GAAGATGCAG ACGCGGACGA TCACTCCTTC
TGGTGCCACA GCCAGTTGGA AGTGGATGGA AGTCAACATT TATTGACTTG TGCTTTTAAT
GACTCAGACA TCAACACAGC TAATCTGGAA TTTCAAATAT GTGGGGCTCT TTTACGAGTG
AAATGCCTAA CTCTTAACAA GCTGCAAGAT ATATATTTTA TAAAGACATC AGAATTCTTA
CTGATTGGTA GCAGCAATAT ATGTGTGAAG CTTGGACAAA AGAATTTAAC TTGCAAAAAT
ATGGCTATAA ACACAATAGT TAAAGCCGAG GCTCCCTCTG ACCTGAAAGT CGTTTATCGC
AAAGAAGCAA ATGATTTTTT GGTGACATTT AATGCACCTC ACTTGAAAAA GAAATATTTA
AAAAAAGTAA AGCATGATGT GGCCTACCGC CCAGCAAGGG GTGAAAGCAA CTGGACGCAT
GTATCTTTAT TCCACACAAG AACAACAATC CCACAGAGAA AACTACGACC AAAAGCAATG
TATGAAATCA AAGTCCGATC CATTCCCCAT AACGATTACT TCAAAGGCTT CTGGAGCGAG
TGGAGTCCAA GTTCTACCTT CGAAACTCCA GAACCCAAGA ATCAAGGAGG ATGGGATCCT
GTCTTGCCAA GTGTCACCAT TCTGAGTTTG TTCTCTGTGT TTTTGTTGGT CATCTTAGCC
CATGTGCTAT GGAAAAAAAG GATTAAACCT GTCGTATGGC CTAGTCTCCC CGATCATAAG
AAAACTCTGG AACAACTATG TAAGAAGCCA AAAACGAGTC TGAATGTGAG TTTCAATCCC
GAAAGTTTCC TGGACTGCCA GATTCATGAG GTGAAAGGCG TTGAAGCCAG GGACGAGGTG
GAAAGTTTTC TGCCCAATGA TCTTCCTGCA CAGCCAGAGG AGTTGGAGAC ACAGGGACAC
AGAGCCGCTG TACACAGTGC AAACCGCTCG CCTGAGACTT CAGTCAGCCC ACCAGAAACA
GTTAGAAGAG AGTCACCCTT AAGATGCCTG GCTAGAAATC TGAGTACCTG CAATGCCCCT
CCACTCCTTT CCTCTAGGTC CCCTGACTAC AGAGATGGTG ACAGAAATAG GCCTCCTGTG
TATCAAGACT TGCTGCCAAA CTCTGGAAAC ACAAATGTCC CTGTCCCTGT CCCTCAACCA
TTGCCTTTCC AGTCGGGAAT CCTGATACCA GTTTCTCAGA GACAGCCCAT CTCCACTTCC
TCAGTACTGA ATCAAGAAGA AGCGTATGTC ACCATGTCTA GTTTTTACCA AAACAAATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

The transcription factor GATA3 is critical for the development of all IL-7Ralpha-expressing innate lymphoid cells
Immunity 40 (3), 378-388 (2014)
Yagi R, Zhong C, Northrup DL, Yu F, Bouladoux N, Spencer S, Hu G, Barron L, Sharma S, Nakayama T, Belkaid Y, Zhao K and Zhu J.


book

In vivo leukemogenic potential of an interleukin 7 receptor alpha chain mutant in hematopoietic stem and progenitor cells
Blood 122 (26), 4259-4263 (2013)
Yokoyama K, Yokoyama N, Izawa K, Kotani A, Harashima A, Hozumi K and Tojo A.


book

Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells
Cell Stem Cell 13 (5), 535-548 (2013)
Boiers C, Carrelha J, Lutteropp M, Luc S, Green JC, Azzoni E, Woll PS, Mead AJ, Hultquist A, Swiers G, Perdiguero EG, Macaulay IC, Melchiori L, Luis TC, Kharazi S, Bouriez-Jones T, Deng Q, Ponten A, Atkinson D, Jensen CT, Sitnicka E, Geissmann F, Godin I, Sandberg R, de Bruijn MF and Jacobsen SE.


book

Type 2 innate lymphoid cells control eosinophil homeostasis
Nature 502 (7470), 245-248 (2013)
Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE and Locksley RM.


book

Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage
Blood 122 (13), 2271-2281 (2013)
Iolyeva M, Aebischer D, Proulx ST, Willrodt AH, Ecoiffier T, Haner S, Bouchaud G, Krieg C, Onder L, Ludewig B, Santambrogio L, Boyman O, Chen L, Finke D and Halin C.


book

Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor
J. Immunol. 154 (4), 1596-1605 (1995)
He YW, Adkins B, Furse RK and Malek TR.


book

Interleukin-7 induces the association of phosphatidylinositol 3-kinase with the alpha chain of the interleukin-7 receptor
Eur. J. Immunol. 24 (9), 2168-2174 (1994)
Venkitaraman AR and Cowling RJ.


book

An interspecific linkage map of mouse chromosome 15 positioned with respect to the centromere
Genomics 13 (4), 1075-1081 (1992)
Brannan CI, Gilbert DJ, Ceci JD, Matsuda Y, Chapman VM, Mercer JA, Eisen H, Johnston LA, Copeland NG and Jenkins NA.


book

Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter
Mol. Cell. Biol. 11 (6), 3052-3059 (1991)
Pleiman CM, Gimpel SD, Park LS, Harada H, Taniguchi T and Ziegler SF.


book

Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily
Cell 60 (6), 941-951 (1990)
Goodwin RG, Friend D, Ziegler SF, Jerzy R, Falk BA, Gimpel S, Cosman D, Dower SK, March CJ and Namen AE.


 
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