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Il7r cDNA ORF clone, Mus musculus (house mouse)

Gene Symbol Il7r
Entrez Gene ID 16197
Full Name interleukin 7 receptor
Synonyms CD127, IL-7Ralpha
General protein information
Preferred Names
interleukin-7 receptor subunit alpha
Names
interleukin-7 receptor subunit alpha
IL-7RA
IL-7R-alpha
IL-7R subunit alpha
IL-7 receptor alpha chain
IL-7 receptor subunit alpha
interleukin 7 receptor alpha chain
Gene Type protein-coding
Organism Mus musculus (house mouse)
Genome

15

15 A1|15 4.16 cM

Summary Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008]. lac of sum

mRNA and Protein(s)

mRNA Protein Name
NM_008372 NP_032398 interleukin-7 receptor subunit alpha precursor



Homo sapiens (human) IL7R NP_002176.2
Pan troglodytes (chimpanzee) IL7R XP_517807.2
Macaca mulatta (Rhesus monkey) IL7R XP_001092582.1
Canis lupus familiaris (dog) IL7R XP_855408.1
Bos taurus (cattle) IL7R NP_001192816.1
Mus musculus (house mouse) Il7r NP_032398.3
Rattus norvegicus (Norway rat) Il7r NP_001099888.1
Gallus gallus (chicken) IL7R NP_001073575.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

The following Il7r gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Il7r cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OMu22595 NM_008372 Mus musculus interleukin 7 receptor (Il7r), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $223.30
$319.00
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OMu22595
Clone ID Related Accession (Same CDS sequence) NM_008372
Accession Version NM_008372.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1380bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-FEB-2015
Organism Mus musculus (house mouse)
Product interleukin-7 receptor subunit alpha precursor
Comment VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY776757.1, AK040364.1, AK042264.1 and BC089571.1. On Feb 22, 2008 this sequence version replaced gi:45269151. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M29697.1, AK042264.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849383 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGATGGCTC TGGGTAGAGC TTTCGCTATA GTTTTCTGCT TAATTCAAGC TGTTTCTGGA 
GAAAGTGGAA ATGCCCAGGA TGGAGACCTA GAAGATGCAG ACGCGGACGA TCACTCCTTC
TGGTGCCACA GCCAGTTGGA AGTGGATGGA AGTCAACATT TATTGACTTG TGCTTTTAAT
GACTCAGACA TCAACACAGC TAATCTGGAA TTTCAAATAT GTGGGGCTCT TTTACGAGTG
AAATGCCTAA CTCTTAACAA GCTGCAAGAT ATATATTTTA TAAAGACATC AGAATTCTTA
CTGATTGGTA GCAGCAATAT ATGTGTGAAG CTTGGACAAA AGAATTTAAC TTGCAAAAAT
ATGGCTATAA ACACAATAGT TAAAGCCGAG GCTCCCTCTG ACCTGAAAGT CGTTTATCGC
AAAGAAGCAA ATGATTTTTT GGTGACATTT AATGCACCTC ACTTGAAAAA GAAATATTTA
AAAAAAGTAA AGCATGATGT GGCCTACCGC CCAGCAAGGG GTGAAAGCAA CTGGACGCAT
GTATCTTTAT TCCACACAAG AACAACAATC CCACAGAGAA AACTACGACC AAAAGCAATG
TATGAAATCA AAGTCCGATC CATTCCCCAT AACGATTACT TCAAAGGCTT CTGGAGCGAG
TGGAGTCCAA GTTCTACCTT CGAAACTCCA GAACCCAAGA ATCAAGGAGG ATGGGATCCT
GTCTTGCCAA GTGTCACCAT TCTGAGTTTG TTCTCTGTGT TTTTGTTGGT CATCTTAGCC
CATGTGCTAT GGAAAAAAAG GATTAAACCT GTCGTATGGC CTAGTCTCCC CGATCATAAG
AAAACTCTGG AACAACTATG TAAGAAGCCA AAAACGAGTC TGAATGTGAG TTTCAATCCC
GAAAGTTTCC TGGACTGCCA GATTCATGAG GTGAAAGGCG TTGAAGCCAG GGACGAGGTG
GAAAGTTTTC TGCCCAATGA TCTTCCTGCA CAGCCAGAGG AGTTGGAGAC ACAGGGACAC
AGAGCCGCTG TACACAGTGC AAACCGCTCG CCTGAGACTT CAGTCAGCCC ACCAGAAACA
GTTAGAAGAG AGTCACCCTT AAGATGCCTG GCTAGAAATC TGAGTACCTG CAATGCCCCT
CCACTCCTTT CCTCTAGGTC CCCTGACTAC AGAGATGGTG ACAGAAATAG GCCTCCTGTG
TATCAAGACT TGCTGCCAAA CTCTGGAAAC ACAAATGTCC CTGTCCCTGT CCCTCAACCA
TTGCCTTTCC AGTCGGGAAT CCTGATACCA GTTTCTCAGA GACAGCCCAT CTCCACTTCC
TCAGTACTGA ATCAAGAAGA AGCGTATGTC ACCATGTCTA GTTTTTACCA AAACAAATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_032398.3
CDS135..1514
Misc Feature(1)522..821(+)
Misc Feature(2)723..785(+)
Misc Feature(3)786..800(+)
Misc Feature(4)786..800(+)
Misc Feature(5)852..926(+)
Misc Feature(6)948..974(+)
Exon (1)1..216
Gene:Il7r
Gene Synonym:
Exon (2)217..355
Gene:Il7r
Gene Synonym:
Exon (3)356..513
Gene:Il7r
Gene Synonym:
Exon (4)514..671
Gene:Il7r
Gene Synonym:
Exon (5)672..840
Gene:Il7r
Gene Synonym:
Exon (6)841..934
Gene:Il7r
Gene Synonym:
Exon (7)935..1010
Gene:Il7r
Gene Synonym:
Exon (8)1011..3210
Gene:Il7r
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_008372
Organism Mus musculus (house mouse)
Definition Mus musculus interleukin 7 receptor (Il7r), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_008372

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGATGGCTC TGGGTAGAGC TTTCGCTATA GTTTTCTGCT TAATTCAAGC TGTTTCTGGA 
GAAAGTGGAA ATGCCCAGGA TGGAGACCTA GAAGATGCAG ACGCGGACGA TCACTCCTTC
TGGTGCCACA GCCAGTTGGA AGTGGATGGA AGTCAACATT TATTGACTTG TGCTTTTAAT
GACTCAGACA TCAACACAGC TAATCTGGAA TTTCAAATAT GTGGGGCTCT TTTACGAGTG
AAATGCCTAA CTCTTAACAA GCTGCAAGAT ATATATTTTA TAAAGACATC AGAATTCTTA
CTGATTGGTA GCAGCAATAT ATGTGTGAAG CTTGGACAAA AGAATTTAAC TTGCAAAAAT
ATGGCTATAA ACACAATAGT TAAAGCCGAG GCTCCCTCTG ACCTGAAAGT CGTTTATCGC
AAAGAAGCAA ATGATTTTTT GGTGACATTT AATGCACCTC ACTTGAAAAA GAAATATTTA
AAAAAAGTAA AGCATGATGT GGCCTACCGC CCAGCAAGGG GTGAAAGCAA CTGGACGCAT
GTATCTTTAT TCCACACAAG AACAACAATC CCACAGAGAA AACTACGACC AAAAGCAATG
TATGAAATCA AAGTCCGATC CATTCCCCAT AACGATTACT TCAAAGGCTT CTGGAGCGAG
TGGAGTCCAA GTTCTACCTT CGAAACTCCA GAACCCAAGA ATCAAGGAGG ATGGGATCCT
GTCTTGCCAA GTGTCACCAT TCTGAGTTTG TTCTCTGTGT TTTTGTTGGT CATCTTAGCC
CATGTGCTAT GGAAAAAAAG GATTAAACCT GTCGTATGGC CTAGTCTCCC CGATCATAAG
AAAACTCTGG AACAACTATG TAAGAAGCCA AAAACGAGTC TGAATGTGAG TTTCAATCCC
GAAAGTTTCC TGGACTGCCA GATTCATGAG GTGAAAGGCG TTGAAGCCAG GGACGAGGTG
GAAAGTTTTC TGCCCAATGA TCTTCCTGCA CAGCCAGAGG AGTTGGAGAC ACAGGGACAC
AGAGCCGCTG TACACAGTGC AAACCGCTCG CCTGAGACTT CAGTCAGCCC ACCAGAAACA
GTTAGAAGAG AGTCACCCTT AAGATGCCTG GCTAGAAATC TGAGTACCTG CAATGCCCCT
CCACTCCTTT CCTCTAGGTC CCCTGACTAC AGAGATGGTG ACAGAAATAG GCCTCCTGTG
TATCAAGACT TGCTGCCAAA CTCTGGAAAC ACAAATGTCC CTGTCCCTGT CCCTCAACCA
TTGCCTTTCC AGTCGGGAAT CCTGATACCA GTTTCTCAGA GACAGCCCAT CTCCACTTCC
TCAGTACTGA ATCAAGAAGA AGCGTATGTC ACCATGTCTA GTTTTTACCA AAACAAATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

The transcription factor GATA3 is critical for the development of all IL-7Ralpha-expressing innate lymphoid cells
Immunity 40 (3), 378-388 (2014)
Yagi R, Zhong C, Northrup DL, Yu F, Bouladoux N, Spencer S, Hu G, Barron L, Sharma S, Nakayama T, Belkaid Y, Zhao K and Zhu J.


book

In vivo leukemogenic potential of an interleukin 7 receptor alpha chain mutant in hematopoietic stem and progenitor cells
Blood 122 (26), 4259-4263 (2013)
Yokoyama K, Yokoyama N, Izawa K, Kotani A, Harashima A, Hozumi K and Tojo A.


book

Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells
Cell Stem Cell 13 (5), 535-548 (2013)
Boiers C, Carrelha J, Lutteropp M, Luc S, Green JC, Azzoni E, Woll PS, Mead AJ, Hultquist A, Swiers G, Perdiguero EG, Macaulay IC, Melchiori L, Luis TC, Kharazi S, Bouriez-Jones T, Deng Q, Ponten A, Atkinson D, Jensen CT, Sitnicka E, Geissmann F, Godin I, Sandberg R, de Bruijn MF and Jacobsen SE.


book

Type 2 innate lymphoid cells control eosinophil homeostasis
Nature 502 (7470), 245-248 (2013)
Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE and Locksley RM.


book

Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage
Blood 122 (13), 2271-2281 (2013)
Iolyeva M, Aebischer D, Proulx ST, Willrodt AH, Ecoiffier T, Haner S, Bouchaud G, Krieg C, Onder L, Ludewig B, Santambrogio L, Boyman O, Chen L, Finke D and Halin C.


book

Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor
J. Immunol. 154 (4), 1596-1605 (1995)
He YW, Adkins B, Furse RK and Malek TR.


book

Interleukin-7 induces the association of phosphatidylinositol 3-kinase with the alpha chain of the interleukin-7 receptor
Eur. J. Immunol. 24 (9), 2168-2174 (1994)
Venkitaraman AR and Cowling RJ.


book

An interspecific linkage map of mouse chromosome 15 positioned with respect to the centromere
Genomics 13 (4), 1075-1081 (1992)
Brannan CI, Gilbert DJ, Ceci JD, Matsuda Y, Chapman VM, Mercer JA, Eisen H, Johnston LA, Copeland NG and Jenkins NA.


book

Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter
Mol. Cell. Biol. 11 (6), 3052-3059 (1991)
Pleiman CM, Gimpel SD, Park LS, Harada H, Taniguchi T and Ziegler SF.


book

Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily
Cell 60 (6), 941-951 (1990)
Goodwin RG, Friend D, Ziegler SF, Jerzy R, Falk BA, Gimpel S, Cosman D, Dower SK, March CJ and Namen AE.


 
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