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Ins2 insulin II [Mus musculus (house mouse)]

Gene Symbol Ins2
Entrez Gene ID 16334
Full Name insulin II
Synonyms AA986540, Ins-2, InsII, Mody, Mody4
General protein information
Preferred Names
insulin-2
Names
insulin-2
Gene Type protein-coding
Organism Mus musculus (house mouse)
Genome

7

7 F5|7 88.0 cM

Summary This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. The encoded precursor protein undergoes proteolytic cleavage to produce a disulfide-linked heterodimeric functional protein that is stored in secretory granules. An increase in blood glucose levels, among others, induces the release of insulin from the secretory granules. Mice deficient in the functional hormone encoded by this gene develop diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. lac of sum
Disorder MIM:

Disorder Html:





Alleles of this type are documented at Mouse Genome Informatics  (MGI)

The following Ins2 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ins2 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OMu22987 NM_008387 Mus musculus insulin II (Ins2), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $99
OMu22987 NM_001185083 Mus musculus insulin II (Ins2), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $99
OMu22987 NM_001185084 Mus musculus insulin II (Ins2), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $99

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OMu22987
Accession Version NM_008387.5 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 333bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 13-AUG-2015
Organism Mus musculus (house mouse)
Product insulin-2 preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP775562.1, AK007612.1 and BC099934.1. On Aug 13, 2015 this sequence version replaced gi:297374792. Summary: This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. The encoded precursor protein undergoes proteolytic cleavage to produce a disulfide-linked heterodimeric functional protein that is stored in secretory granules. An increase in blood glucose levels, among others, induces the release of insulin from the secretory granules. Mice deficient in the functional hormone encoded by this gene develop diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BQ127829.1, AK007612.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
ATGGCCCTGT GGATGCGCTT CCTGCCCCTG CTGGCCCTGC TCTTCCTCTG GGAGTCCCAC 
CCCACCCAGG CTTTTGTCAA GCAGCACCTT TGTGGTTCCC ACCTGGTGGA GGCTCTCTAC
CTGGTGTGTG GGGAGCGTGG CTTCTTCTAC ACACCCATGT CCCGCCGTGA AGTGGAGGAC
CCACAAGTGG CACAACTGGA GCTGGGTGGA GGCCCGGGAG CAGGTGACCT TCAGACCTTG
GCACTGGAGG TGGCCCAGCA GAAGCGTGGC ATTGTAGATC AGTGCTGCAC CAGCATCTGC
TCCCTCTACC AGCTGGAGAA CTACTGCAAC TAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_032413.1
CDS92..424
Misc Feature(1)11..13(+)
Misc Feature(2)167..421(+)
Misc Feature(3)185..415(+)
Exon (1)1..65
Gene:Ins2
Gene Synonym:
Exon (2)66..278
Gene:Ins2
Gene Synonym:
Exon (3)279..481
Gene:Ins2
Gene Synonym:
Translation
Position Chain Variation Link

Target ORF information:

RefSeq Version NM_008387
Organism Mus musculus (house mouse)
Definition Mus musculus insulin II (Ins2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_008387

ORF Insert Sequence:

1
61
121
181
241
301
ATGGCCCTGT GGATGCGCTT CCTGCCCCTG CTGGCCCTGC TCTTCCTCTG GGAGTCCCAC 
CCCACCCAGG CTTTTGTCAA GCAGCACCTT TGTGGTTCCC ACCTGGTGGA GGCTCTCTAC
CTGGTGTGTG GGGAGCGTGG CTTCTTCTAC ACACCCATGT CCCGCCGTGA AGTGGAGGAC
CCACAAGTGG CACAACTGGA GCTGGGTGGA GGCCCGGGAG CAGGTGACCT TCAGACCTTG
GCACTGGAGG TGGCCCAGCA GAAGCGTGGC ATTGTAGATC AGTGCTGCAC CAGCATCTGC
TCCCTCTACC AGCTGGAGAA CTACTGCAAC TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OMu22987
Accession Version NM_001185083.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 333bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 13-AUG-2015
Organism Mus musculus (house mouse)
Product insulin-2 preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP775562.1 and BC099934.1. On Aug 13, 2015 this sequence version replaced gi:297374793. Summary: This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. The encoded precursor protein undergoes proteolytic cleavage to produce a disulfide-linked heterodimeric functional protein that is stored in secretory granules. An increase in blood glucose levels, among others, induces the release of insulin from the secretory granules. Mice deficient in the functional hormone encoded by this gene develop diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. Transcript Variant: This variant (1) represents the shortest transcript. Variants 1-3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CF581924.1, BG310959.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
ATGGCCCTGT GGATGCGCTT CCTGCCCCTG CTGGCCCTGC TCTTCCTCTG GGAGTCCCAC 
CCCACCCAGG CTTTTGTCAA GCAGCACCTT TGTGGTTCCC ACCTGGTGGA GGCTCTCTAC
CTGGTGTGTG GGGAGCGTGG CTTCTTCTAC ACACCCATGT CCCGCCGTGA AGTGGAGGAC
CCACAAGTGG CACAACTGGA GCTGGGTGGA GGCCCGGGAG CAGGTGACCT TCAGACCTTG
GCACTGGAGG TGGCCCAGCA GAAGCGTGGC ATTGTAGATC AGTGCTGCAC CAGCATCTGC
TCCCTCTACC AGCTGGAGAA CTACTGCAAC TAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001172012.1
CDS80..412
Misc Feature(1)11..13(+)
Misc Feature(2)155..409(+)
Misc Feature(3)173..403(+)
Exon (1)1..65
Gene:Ins2
Gene Synonym:
Exon (2)66..266
Gene:Ins2
Gene Synonym:
Exon (3)267..469
Gene:Ins2
Gene Synonym:
Translation
Position Chain Variation Link

Target ORF information:

RefSeq Version NM_001185083
Organism Mus musculus (house mouse)
Definition Mus musculus insulin II (Ins2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001185083

ORF Insert Sequence:

1
61
121
181
241
301
ATGGCCCTGT GGATGCGCTT CCTGCCCCTG CTGGCCCTGC TCTTCCTCTG GGAGTCCCAC 
CCCACCCAGG CTTTTGTCAA GCAGCACCTT TGTGGTTCCC ACCTGGTGGA GGCTCTCTAC
CTGGTGTGTG GGGAGCGTGG CTTCTTCTAC ACACCCATGT CCCGCCGTGA AGTGGAGGAC
CCACAAGTGG CACAACTGGA GCTGGGTGGA GGCCCGGGAG CAGGTGACCT TCAGACCTTG
GCACTGGAGG TGGCCCAGCA GAAGCGTGGC ATTGTAGATC AGTGCTGCAC CAGCATCTGC
TCCCTCTACC AGCTGGAGAA CTACTGCAAC TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OMu22987
Accession Version NM_001185084.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 333bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 13-AUG-2015
Organism Mus musculus (house mouse)
Product insulin-2 preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP775562.1, AY899305.1 and BC099934.1. On Aug 13, 2015 this sequence version replaced gi:297374795. Summary: This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. The encoded precursor protein undergoes proteolytic cleavage to produce a disulfide-linked heterodimeric functional protein that is stored in secretory granules. An increase in blood glucose levels, among others, induces the release of insulin from the secretory granules. Mice deficient in the functional hormone encoded by this gene develop diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI900780.1, AY899305.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
ATGGCCCTGT GGATGCGCTT CCTGCCCCTG CTGGCCCTGC TCTTCCTCTG GGAGTCCCAC 
CCCACCCAGG CTTTTGTCAA GCAGCACCTT TGTGGTTCCC ACCTGGTGGA GGCTCTCTAC
CTGGTGTGTG GGGAGCGTGG CTTCTTCTAC ACACCCATGT CCCGCCGTGA AGTGGAGGAC
CCACAAGTGG CACAACTGGA GCTGGGTGGA GGCCCGGGAG CAGGTGACCT TCAGACCTTG
GCACTGGAGG TGGCCCAGCA GAAGCGTGGC ATTGTAGATC AGTGCTGCAC CAGCATCTGC
TCCCTCTACC AGCTGGAGAA CTACTGCAAC TAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001172013.1
CDS194..526
Misc Feature(1)125..127(+)
Misc Feature(2)269..523(+)
Misc Feature(3)287..517(+)
Exon (1)1..380
Gene:Ins2
Gene Synonym:
Exon (2)381..583
Gene:Ins2
Gene Synonym:
Translation
Position Chain Variation Link

Target ORF information:

RefSeq Version NM_001185084
Organism Mus musculus (house mouse)
Definition Mus musculus insulin II (Ins2), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001185084

ORF Insert Sequence:

1
61
121
181
241
301
ATGGCCCTGT GGATGCGCTT CCTGCCCCTG CTGGCCCTGC TCTTCCTCTG GGAGTCCCAC 
CCCACCCAGG CTTTTGTCAA GCAGCACCTT TGTGGTTCCC ACCTGGTGGA GGCTCTCTAC
CTGGTGTGTG GGGAGCGTGG CTTCTTCTAC ACACCCATGT CCCGCCGTGA AGTGGAGGAC
CCACAAGTGG CACAACTGGA GCTGGGTGGA GGCCCGGGAG CAGGTGACCT TCAGACCTTG
GCACTGGAGG TGGCCCAGCA GAAGCGTGGC ATTGTAGATC AGTGCTGCAC CAGCATCTGC
TCCCTCTACC AGCTGGAGAA CTACTGCAAC TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.