Tissue Array and Tissue Block Service
I. Customized Tissue Collection and Tissue Paraffin Block Preparation
GenScript has established a sophisticated and integrated tissue collection network in compliance with FDA GLP guidelines to collect diseased and normal tissues for individual research requirements. Our one-stop service covers clinical data collection, tissue sample registration, tissue collection, transportation, storage, processing, paraffin embedding, pathological identification and validation, and tissue database management.
GenScript tissue collection strictly follows the approved ethical guidelines ensuring the confidentiality and safety of patient information. All tissues to be collected are waived of intellectual property right and ownership right by tissue donors. The tissues can be delivered in paraffin block format. Our clinical annotations for tissues collection include full clinical information including date of initial diagnosis, medical history, and therapy history. Our compliant sample logistics and management system has been audited and approved by multiple global pharmaceutical companies. Shown in Table 1 is an overview of our tissue portfolio.
Table 1. Overview of GenScript tissue portfolio |
| Adrenal |
Cervix |
Kidney |
Ovary |
Skin |
Thymus |
| Brain |
Colon |
Liver |
Pancreas |
Soft Tissues |
Thyroid |
| Bladder |
Esophagus |
Lung |
Parathyoid |
Stomach |
Ureter |
| Bone |
Fallopian tube |
Lymphoma and lymph node |
Prostate |
Spleen |
Urethra |
| Breast |
Head and neck |
Muscle |
Rectum |
Testis |
Uterus |
The collected tissues can be immediately quenched in liquid N2 then transferred to -80°C if DNA, RNA or protein preparation from the collected tissues are requested; or fixed in freshly prepared 10% formalin then processed within 24 hours for tissue paraffin block preparation and tissue array production.
Customized tissue paraffin block preparation (SC1186)
GenScript offers paraffin block preparation to the customized tissue collection. The standard procedure for clinical histological analysis is used in our paraffin block preparation, in which tissues are infused with melted paraffin and embedded in a square mold, suitable for microtome sectioning and array production. The histopathological data of each tissue specimen is independently reviewed and mapped by two certified histo-pathologists. GenScript delivers tissue paraffin blocks with full clinical information and QC reports.
Service for DNA, RNA or protein extraction from customized frozen tissues (SC1187)
GenScript offers service for DNA, RNA, and protein extraction from customized frozen tissues. Extracted DNA, RNA and proteins can be used for PCR, RT-PCR, DNA microarray hybridization, 2-D gel, and proteomics. GenScript also offers comprehensive downstream analytical services including comparative parallel DNA microarray analysis using chips from Affymatrix, GE Healthcare, Illumina, and Agilent.
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II. Customized Tissue Array Production
Tissue Array Production Using Tissue Blocks from Clients (SC1188)
GenScript recommends that its clients collect tissue specimens from the designed experiments and fix these tissue specimens in freshly prepared 10% formallin in phosphate buffer. GenScript provides downstream services that cover entire tissue array production process, including paraffin embedding, sectioning, staining, histopathological evaluation, array design, and diagnosis.
The tissue array formats or panels will be designed by certified histo-pathologists and processed by experienced professionals according to customers' requirements. Every 10th array will be H&E stained and evaluated by histo-pathologists.
Tissue Array Production Using Tissue Blocks from GenScript (SC1189)
GenScript also provides customized tissue array services using its pre-made tissue blocks following the same processing and QC procedures as described above.
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III. Tissue Array Analysis and Data Processing (SC1190) GenScript offers array analysis and data processing services for both tissue arrays produced at GenScript and those provided by clients. Our tissue array analysis services include the following:
- H&E staining
- Immunohistochemistry (IHC) staining
- In situ hybridization (ISH)
- Fluorescent in situ hybridization (FISH)
- In situ PCR
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- In situ RT-PCR
- Primed in situ labeling (PRINS)
- Spot-to-spot data analysis
- Data and image processing
- Typical image processing
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Sample Submission Requirements:
GenScript accepts only tissue paraffin blocks from clients. Please download and complete GenScript Tissue Submission Form, send it to order@genscript.de with the detailed contact information requested in the form. Tissue blocks should be submitted along with a hard copy of the Tissue Submission Form to Tissue Array Services, GenScript, 120 Centennial Ave., Suite 105, Piscataway, NJ 08854, US.
Quotations and Ordering Information:
 For quotation requests, consultations, estimates, and questions. Please contact us by email, phone, or fax. Please also download and complete our Tissue Array Quotation/Order Form, and send it to us by email or via secure web server.
Orders may be placed by email, phone, fax with either a formal PO (Purchase Order) or credit card. Our customer service representatives are available 24 hours, Monday through Friday to assist you.
If submitting tissue paraffin blocks, please include hard copies of completed Tissue Submission Form and completed Quotation/Order Form, send in one package to Tissue Array Service, GenScript, 120 Centennial Ave., Suite 105, Piscataway, NJ 08854, US.
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Email for Quotation and Ordering: order@genscript.de |
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Ordering by Telephone: 001-732-885-9188 (USA)
Toll Free Tel. No.: 0-800-0006-320 (Germany) 0800-369-254 (Switzerland) |
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Fax: 001-732-210-0262 001-732-885-5878 |
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