GIATE Common Data Elements Viewer
Guidelines and Information About Therapy Experiments (GIATE) is a data standard for recording data about therapy experiments. It is promoted by the Antibody Society, as a data standard for antibody therapy experiments. However the data standard can also equally be used to describe a wide range of therapeutics. (Read more ... )
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GIATE categorises the information about therapy experiments into three classes, that is, information about the target, therapy agent and models used to test the therapy. Nested within these classes are additional classes describing different aspects and properties of the parent class. Therefore, a logical representation of GIATE would be a tree, with three main branches, which stems into smaller branches and leaves. The first branch addresses the information about the targets of the therapeutic. The target may be a gene product, an organic chemical or a small molecule. There may be more then a single target in a course of therapy, and these targets may be a combination of any of these classes. Different pieces of information are relevant to the different target types. The second branch addresses the information about the therapeutic agents. Again, there may be different types of agents, with the appropriate properties. For example, an antibody would be a type of therapeutic agents, and there would be component types to describe the components of the antibody itself. The third branch addresses the models used to test the therapy. This consists of molecular, cellular models, animal and clinical models. There are different properties which addresses each model, from the experimental conditions of the molecular models, to the species and target homology to man of the animal, to the MABEL and NOAEL information for the patient. For each of the models, GIATE specifies a set of measurements for describing the quantities of the targets and therapeutic agents, the methods of administration, and the effects and outcomes of administering the agents. Read more ...References: |
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Unit of MeasurementDevelopment of GIATE was supported by the UCL Experimental Cancer Medicine Centre, the UCL/UCLH Comprehensive Biomedical Research Centre of the UK NIHR and the Antibody Society. We would also like to thank GenScript for hosting and developing this web interface for GIATE.