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Immune Checkpoint Antibodies and Proteins

Immune checkpoint-blocking antibodies that activate the immune system to fight cancer are becoming an important method of cancer treatment. CTLA-4 was the first immune checkpoint target and ipilimumab, an anti CTLA-4 antibody drug, was approved in 2011 for clinical use. The PD-1 receptor and its ligand PD-L1 have shown great promise as therapeutic targets in a variety of malignancies. The combined- target immunotherapy may have a higher level of effect in the future.

To facilitate this hot immunotherapy research field, GenScript provides immune checkpoint antibodies and proteins for many kinds of applications. Products for more targets are coming in succession.


Monoclonal antibody ordering list

Cat. No.
Product Name
Size
Price
Quantity
A01852-40 MonoRab™ Anti-Pembrolizumab Antibody, mAb, Rabbit
40 μg
$198.00
A01853-40 MonoRab™ Anti-Pembrolizumab Antibody[BIOTIN], mAb, Rabbit
40 μg
$198.00
 

Polyclonal antibody ordering list

Cat. No.
Product Name
Size
Price
Quantity
A01846-40 Anti-Pembrolizumab Antibody, pAb, Rabbit
40 μg
$198.00
 

Immune checkpoint antibody application

  • Positive control for human antibody drug early development
  • Surrogate antibody (mouse anti-mouse antibody)
  • Anti-immune checkpoint antibody drug antibodies (Anti-idiotype Antibodies)

Ordering List

Application

Drug candidate antibody

  • Positive control of antibody drug development
  • For cell line development
  • For assay development

Target Cat.No. Product Name ELISA FACS Functional Assay
PD1
A01828-40
A01829-40
PDL1
A01830-40
A01831-40
CTLA-4
A01832-40
A01833-40
TIM3
A01834-40
A01835-40
LAG3
A01836-40
Human LAG3 Antibody (Clone A), mAb, Mouse
 
A01837-40
Human LAG3 Antibody (Clone B), mAb, Mouse
 

Surrogate antibody

  • For target validation
  • Combo therapy evaluation

Target Cat.No. Product Name ELISA FACS Functional Assay
PD1
A01838-40
Mouse PD1 Antibody (9D5), mAb, Mouse
A01839-40
Mouse PD1 Antibody (15A8), mAb, Mouse
PDL1
A01840-40
Mouse PDL1 Antibody (44E2), mAb, Mouse
A01841-40
Mouse PDL1 Antibody (44E9), mAb, Mouse
CTLA-4
A01842-40
A01843-40

Anti-idiotype antibody

  • Bioanalytical Method Development (PK/PD)
  • Immunogenicity study

Target: PD-1

Drug Name Cat.No. Product Name Clone ID Inhibitory,
IC50 (μg/ml)
Recommend applications
Pembrolizumab (Keytruda) A01844-40 Anti-Pembrolizumab Antibody mAb, Mouse 1D6E10 Non-inhibitory Indirect ELISA,
Capture antibody for pembrolizumab, PK/PD bridging ELISA with A01845
A01845-40 Anti-Pembrolizumab Antibody [Biotin], mAb, Mouse 10E12C6 0.37 Direct/Inhibitory ELISA,
Detection antibody for pembrolizumab, PK/PD bridging ELISA with A01844
A01852-40
MonoRab™ Anti-Pembrolizumab Antibody, mAb, Rabbit 129G11B9 Non-inhibitory Indirect ELISA,
Capture antibody for pembrolizumab, PK/PD bridging ELISA with A01853
A01853-40
MonoRab™ Anti-Pembrolizumab Antibody [BIOTIN], mAb, Rabbit 90G12F8 0.38 Direct/Inhibitory ELISA,
Detection antibody for pembrolizumab, PK/PD bridging ELISA with A01852
A01846-40 Anti-Pembrolizumab Antibody, pAb, Rabbit   N/A Direct ELISA
Immunogenicity assay
Nivolumab (Opdivo) A01847-40 Anti-Nivolumab Antibody, mAb, Mouse 8G6G3D8 Non-inhibitory Indirect ELISA,
Capture antibody for Nivolumab, PK/PD bridging ELISA with A01848-40 
A01848-40 Anti-Nivolumab Antibody [Biotin], mAb, Mouse 6G5H2E6 Non-inhibitory Direct/Indirect ELISA,
Detection antibody for Nivolumab, PK/PD bridging ELISA with A01847-40 

Target: CTLA-4

Drug Name Cat.No. Product Name Clone ID Inhibitory,
IC50 (μg/ml)
Recommend applications
Ipilimumab (Yervoy) A01859-40 Anti-Ipilimumab Antibody, mAb, Mouse 26B6H7D9 Non-inhibitory Indirect ELISA,
Capture antibody for Ipilimumab, PK/PD bridging ELISA with A01858-40 
A01858-40 Anti-Ipilimumab Antibody [Biotin], mAb, Mouse 4H6E1D4 Non-inhibitory Direct/Indirect ELISA,
Detection antibody for Ipilimumab, PK/PD bridging ELISA with A01859-40 

Immune checkpoint protein application

  • Modulate immune responses
  • Identify binding partners
  • Discover novel drugs
  • Antibody production

Upcoming proteins for the following targets

Target Cat. No.
Human PD-1 Z03370
Human PD-L1 Z03371
Human CTLA4 Z03373
Human CD40 ECD Z03398
Human OX40 Coming soon
Human TIM3 Z03392
Human CD137 Z03382
Human HVEM Z03224
Human VSIG8-Ig Z03399
Human CD40L Z02022
Human CD40L Z02727
Human VISTA Z03397
Human 4-1BB L Z03406
Human CD80 Coming soon
Human LAG3 Coming soon
Mouse OX40 Z03403
Mouse TIM3 Z03401
 
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