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Immune Checkpoint Antibodies and Proteins

Immune checkpoint-blocking antibodies that activate the immune system to fight cancer are becoming an important method of cancer treatment. CTLA-4 was the first immune checkpoint target and ipilimumab, an anti CTLA-4 antibody drug, was approved in 2011 for clinical use. The PD-1 receptor and its ligand PD-L1 have shown great promise as therapeutic targets in a variety of malignancies. The combined- target immunotherapy may have a higher level of effect in the future.

To facilitate this hot immunotherapy research field, GenScript provides immune checkpoint antibodies and proteins for many kinds of applications. Products for more targets are coming in succession.


Monoclonal antibody ordering list

Cat. No.
Product Name
Size
Price
Quantity
A01852-40 MonoRab™ Anti-Pembrolizumab Antibody (129G11B9), mAb, Rabbit
40 μg
$198.00
A01853-40 MonoRab™ Anti-Pembrolizumab Antibody (90G12F8)[BIOTIN], mAb, Rabbit
40 μg
$198.00
 

Polyclonal antibody ordering list

Cat. No.
Product Name
Size
Price
Quantity
A01846-40 Anti-Pembrolizumab Antibody, pAb, Rabbit
40 μg
$198.00
 

Immune checkpoint antibody application

  • Positive control for human antibody drug early development
  • Surrogate antibody (mouse anti-mouse antibody)
  • Anti-immune checkpoint antibody drug antibodies (Anti-idiotype Antibodies)

Ordering List

Application

Drug candidate antibody

  • Positive control of antibody drug development
  • For cell line development
  • For assay development

Target Cat.No. Product Name ELISA FACS Functional Assay
PD1
A01828-40
Anti-Human PD-1 Antibody (PD1.H5), mAb, Mouse
A01829-40
Anti-Human PD-1 Antibody (PD1.D3), mAb, Mouse
PDL1
A01830-40
Anti-Human PD-L1 Antibody (PDL1.D1), mAb, Mouse
A01831-40
Anti-Human PD-L1 Antibody (PDL1.A6), mAb, Mouse
CTLA-4
A01832-40
Anti-Human CTLA-4 Antibody (CT.F3), mAb, Mouse
A01833-40
Anti-Human CTLA-4 Antibody (CT.E8), mAb, Mouse
TIM3
A01834-40
Anti-Human TIM3 Antibody (TI.B2), mAb, Mouse
A01835-40
Anti-Human TIM3 Antibody (TI.H3), mAb, Mouse
LAG3
A01836-40
Human LAG3 Antibody (Clone A), mAb, Mouse
 
A01837-40
Human LAG3 Antibody (Clone B), mAb, Mouse
 

Surrogate antibody

  • For target validation
  • Combo therapy evaluation

Target Cat.No. Product Name ELISA FACS Functional Assay
PD1
A01838-40
Mouse PD1 Antibody (9D5), mAb, Mouse
A01839-40
Mouse PD1 Antibody (15A8), mAb, Mouse
PDL1
A01840-40
Mouse PDL1 Antibody (44E2), mAb, Mouse
A01841-40
Mouse PDL1 Antibody (44E9), mAb, Mouse
CTLA-4
A01842-40
Anti-Mouse CTLA-4 Antibody (MCT.F6), mAb, Mouse
A01843-40
Anti-Mouse CTLA-4 Antibody (MCT.E9), mAb, Mouse

Anti-idiotype antibody

  • Bioanalytical Method Development (PK/PD)
  • Immunogenicity study

Target Cat.No. Product Name ELISA FACS Functional Assay
Pembrolizumab
A01844-40
Anti-Pembrolizumab Antibody (1D6E10) mAb, Mouse
A01845-40
Anti-Pembrolizumab Antibody (10E12C6)[Biotin], mAb, Mouse
A01846-40
Anti-Pembrolizumab Antibody, pAb, Rabbit
Nivolumab
A01847-40
Anti-Nivolumab/ (Opdivo), mAb clone A
A01848-40
Anti-Nivolumab/ (Opdivo), mAb clone B

Immune checkpoint protein application

  • Modulate immune responses
  • Identify binding partners
  • Discover novel drugs
  • Antibody production

Upcoming proteins for the following targets

Target Cat. No.
Human PD-1 Z03370
Human PD-L1 Z03371
Human CTLA4 Z03373
Human CD40 ECD Z03398
Human OX40 Coming soon
Human TIM3 Z03392
Human CD137 Z03382
Human HVEM Z03224
Human VSIG8-Ig Z03399
Human CD40L Z02022
Human CD40L Z02727
Human VISTA Z03397
Human 4-1BB L Z03406
Human CD80 Coming soon
Human LAG3 Coming soon
Mouse OX40 Z03403
Mouse TIM3 Z03401
 
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