Immuno-oncology (cancer immunotherapy), describes the process of utilizing the patient’s own immune system to fight cancer. In the last decade, immuno-oncology has emerged as an exciting new approach to cancer treatment because of its specificity, adaptability and durability. One of the key areas within this field is a new class of proteins called immune checkpoints, such as PD-1 and CTLA-4 among others, which could enable cancer cells to hide from the immune system by modulating T cell signaling. Immune-checkpoints are being studied extensively as a new type of targets for cancer immunotherapy.
GenScript provides the One-Stop Platform to accelerate your immuno-oncology research, including numerous neutralizing immune checkpoint antibodies and anti-idiotypes (IDs), stable cell lines expressing immuno-oncology proteins at high levels, a wide range of purified recombinant proteins involved in immuno-signaling pathways, together with assay platforms for drug discovery and development.
|Immune Checkpoint Antibodies
GenScript provides multifunctional immune checkpoint antibody products to facilitate your immunotherapy research.
Several cell-based immune-checkpoint functional assays are available to determine immuno-modulatory profiles of antibody leads.
|Immuno-Oncology Recombination Proteins
The high-quality Immune Checkpoint Proteins in GenScript can support many kinds of researches in immune-oncology field
|ADCC & CDC assays
By implementing strict QC standards, GenScript provides the assurance of the efficacy and potency profiles of your therapeutic antibodies.
|Stable Cell Lines for Immuno-Oncology Research (CellPowerTM)
Both immune checkpoints and oncogene expressed stable cell lines are supplied;
|Tumor Cell Line Profiling
OncoProfiler and XenoProfiler not only provide efficacy data in human tumor cell lines, but also ensure translation of efficacy from in vitro to in vivo models.
|Animal Tumor Models
GenScript provides syngeneic tumor models, huPBMC engrafted tumor models and immune checkpoint humanized models for drug efficacy or proof-of-concept studies.