Peripherin Antibody, pAb, Rabbit
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Peripherin Antibody, pAb, Rabbit  |
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| Full Name |
Peripherin Antibody, pAb, Rabbit
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Abbreviated name-1 |
Rabbit Anti-Peripherin pAb; Anti Peripherin |
| Documents |
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 Document-MSDS: 7039_20081020212020.PDF (PDF) |
| Figures |
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| Reference |
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Wildner H, et al. dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development. Development. Jun 2006; 133(11): 2105-2113.
Chang L, et al. Assembling an intermediate filament network by dynamic cotranslation. J. Cell Biol. Feb 2006; 172(5): 747-758.
Anitha M, et al. GDNF rescues hyperglycemia-induced diabetic enteric neuropathy through activation of the PI3K/Akt pathway. J. Clin. Invest. Feb 2006; 116(2): 344-356.
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Description |
Peripherin is a Class III intermediate filament subunit found in both the peripheral and central nervous systems, though it is concentrated, as its name suggests, in the neurons of peripheral ganglia and their processes. Antibodies to peripherin can be used in identifying, classifying, and studying neurons in the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrigs disease and some neuronally derived tumors. Peripherin is also a major component of the cytoskeleton of PC12 cells, a widely used model system for studies of neuronal differentiation. Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes. Peripherin is not related to peripherin RDS, a photoreceptor protein associated with retinal degeneration and blindness. |
Ig Subclass |
Rabbit IgG |
Storage |
Stable for one year at -20ºC from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Aliquot will be stable at 4ºC for 3 months. |
Specificity |
Peripherin from human, rat, rabbit, cat, mouse |
Concentration |
1 mg/ml in PBS, pH 7.4 with 0.05% sodium azide, frozen liquid |
Immunogen |
Recombinant full length peripherin purified from E. coli |
Purification Method |
Immunoaffinity purification |
Applications |
Immunocytochemistry on cells in tissue culture or in tissue sections: 1:500 using fluorescent secondary antibodies or 1:2,500 using peroxidase or other enzyme linked methods.
Western blot: 1:10,000 |
Conjugation |
Unconjugated |
Species Reactivity |
Human, rat, rabbit, cat, mouse |
Host Species |
Rabbit |
Antigen Species |
Human |
Note |
Briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container's cap because small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage. |
Technical Manual |
TM0589.pdf (PDF)
TM0590.pdf (PDF)
TM0591.pdf (PDF)
TM0592.pdf (PDF)
TM0593.pdf (PDF)
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