Peripherin Antibody, mAb, Mouse
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Peripherin Antibody, mAb, Mouse  |
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| Full Name |
Peripherin Antibody, mAb, Mouse
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Abbreviated name-1 |
Peripherin Antibody, mAb, Mouse; |
| Documents |
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 Document-MSDS: 7045_20081020213150.PDF (PDF) |
| Figures |
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zoom |
| Reference |
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Keilhauer CN, et al. Clinical Findings in a Multigeneration Family With Autosomal Dominant Central Areolar Choroidal Dystrophy Associated With an Arg195Leu Mutation in the Peripherin/RDS Gene. Arch. Ophthalmol. Jul 2006; 124(7): 1020-1027.
Lee ES, et al. Characterization of peripherin/rds and rom-1 transport in rod photoreceptors of transgenic and knockout animals. Invest. Ophthalmol. Vis. Sci. May 2006; 47(5): 2150-2160.
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Description |
Peripherin is a 57,000 Da Class III intermediate filament subunit found initially in sensory neurons of the peripheral nervous system, which gives the protein its name. Certain sensory neurons in the brain stem express peripherin normally, as do a few cortical and hippocampal neurons. Interestingly, peripherin protein is upregulated in the lower motor neurons that degenerate in Amyotrophic Lateral Sclerosis (ALS), focusing attention on peripherin as a potential contributory factor to this serious human neurodegenerative disease. Peripherin is also expressed in certain neuroendocrine tumors and in the insulinproducing cells of the pancreas. |
Ig Subclass |
IgG |
Storage |
Stable for one year at -20ºC from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Aliquot will be stable at 4ºC for 3 months. |
Specificity |
Peripherin from human, rat, cat, mouse. The antibody recognizes only peripherin 1 or PRPH. |
Concentration |
1 mg/ml in PBS, pH 7.4 with 0.05% sodium azide, frozen liquid |
Immunogen |
Recombinant rat peripherin purified from E. coli |
Purification Method |
Immunoaffinity purification |
Applications |
ICC: 1:500
WB: 1:2,500 |
Conjugation |
Unconjugated |
Species Reactivity |
Human, rat, cat, mouse |
Host Species |
Mouse |
Antigen Species |
Rat |
Note |
Briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container's cap because small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage. |
Technical Manual |
TM0589.pdf (PDF)
TM0590.pdf (PDF)
TM0591.pdf (PDF)
TM0592.pdf (PDF)
TM0593.pdf (PDF)
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