The altered state caused by stress, trauma, disease, aging, etc. The cumulative burden (stated in physiological, endocrinological or psychiatric terms, depending upon the context) of the shift from homeostasis to allostasis, is the allostatic load.Seeman, T.E., Singer, B.H., Rowe, J.W., Horwitz, R.I. and McEwen, B.S. (1997) Arch. Intern. Med. 157, 2259-2268

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