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*This product has been discontinued! *
| Product Name |
CHO-K1/EDNRA Cells Ready-To-UseTM |
Full Name |
Endothelin receptor type A, in CHO-K1 cells Ready-to-UseTM |
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Description |
In mammals, the endothelin (ET) family comprises three endogenous isoforms: ET-1, ET-2, and ET-3. These endothelium-derived peptides perform their functions via two endothelin receptors, classified as EDNRA and EDNRB. EDNRA receptors are mainly localized in the vascular smooth muscle cells, where they are the predominant sub-type, and mediate vasoconstriction and proliferation. Selective EDNRA antagonists are effective in the treatment of heart failure, essential hypertension, pulmonary hypertension, and atherosclerosis. |
Storage |
Liquid nitrogen |
Application Examples |
This diagram depicts the calcium dose-response of ET-1 stimulation of CHO-K1/EDNRA Cells Ready-to-UseTM (●) and non-treated cells (○). The resulting increase in intracellular calcium was measured on a FlexStation fluorescent plate reader. Data points represent the average +/- standard deviation of triplicate determinations. |
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TECHNICAL MANUAL: 20090106040829 (PDF)
