CHO-K1/ADRB2/Gα15 Stable Cell Line
*This product has been discontinued! *
|Description||β-Adrenergic receptors (β-ARs) are members of the superfamily G-protein-coupled receptors that are stimulated by naturally occurring catecholamines, epinephrine, and norepinephrine. As part of the sympathetic nervous system, β-ARs have been shown to have important roles in cardiovascular, respiratory, metabolic, central nervous system, and reproductive functions. Three distinct β-AR subtypes have been identified (β1-AR, β2-AR, and β3-AR). All three of these β-AR subtypes are believed to signal by coupling to the stimulatory G-protein Gsα which leads to the activation of adenylyl cyclase and accumulation of the second messenger cAMP. β1-ARs mediate cardiac stimulation, β2-ARs mediate smooth muscle relaxation in the peripheral vasculature and respiratory system, and β3-AR has been shown to have important roles in adipose tissue and gastrointestinal tract. In studies using subtype-selective agonists and antagonists in the human heart, β2-AR stimulation leads to the activation of adenylyl cyclase and contributes to both inotropic and chronotropic responses.|
|Application||Functional assay for ADRB2 receptor|
|Storage||Liquid nitrogen immediately upon delivery|
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