Human BB3 Receptor Membrane Preparation

Bombesin, a bioactive peptide first identified in amphibian skin, is related to two mammalian peptides, gastrin-releasing peptide (GRP) and neuromedin B. A family of 4 GPCRs, including GRP-R (BB1), NMB-R (BB2), BRS-3 (BB3) and BRS-4, mediates the biological effects of the peptides. The bombesin receptor subtype 3, BB3 (also known as BRS3), is a third mammalian bombesin receptor subtype and no endogenous ligand has been identified to date. BB3 expression has been reported in lung (normal and cancer), nasal mucosa, placenta, and uterus. BB3-null mice have an obese phenotype, which suggests that BB3 may be an important target for obesity research. In addition, BB3 may be involved in diabetes and hypertension.