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*This product has been discontinued! *
| Product Name |
Human BB3 Receptor Membrane Preparation |
Species |
Human |
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Description |
Bombesin, a bioactive peptide first identified in amphibian skin, is related to two mammalian peptides, gastrin-releasing peptide (GRP) and neuromedin B. A family of 4 GPCRs, including GRP-R (BB1), NMB-R (BB2), BRS-3 (BB3) and BRS-4, mediates the biological effects of the peptides. The bombesin receptor subtype 3, BB3 (also known as BRS3), is a third mammalian bombesin receptor subtype and no endogenous ligand has been identified to date. BB3 expression has been reported in lung (normal and cancer), nasal mucosa, placenta, and uterus. BB3-null mice have an obese phenotype, which suggests that BB3 may be an important target for obesity research. In addition, BB3 may be involved in diabetes and hypertension. |
Host Cell |
CHO-K1/M1 |
Concentration |
1 mg/ml in 50 mM HEPES, 5 mM MgCl2, 1 mM CaCl2 and 0.2% BSA, pH7.4 |
Storage |
Store at -80°C |
Application |
Binding assay for BB3 receptor |
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TECHNICAL MANUAL: 11288_20091126223114.PDF (PDF)