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*This product has been discontinued! *
| Product Name |
Human D2 Receptor Membrane Preparation |
Species |
Human |
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Description |
Dopamine is the predominant catecholamine neurotransmitter found in mammalian brain, where it controls a variety of functions including locomotor activity, cognition, emotion, positive reinforcement, food intake, and endocrine regulation. It also plays multiple roles in the periphery as a modulator of cardiovascular function, catecholamine release, hormone secretion, vascular tone, renal function, and gastrointestinal motility. The dopamine receptor family consists of five members, which are classified into two groups, D1-like (D1 and D5) and D2-like (D2, D3, and D4). Dopamine receptor 2 is mainly expressed in the brain. It has splicing variants, D2L and D2S. D2R receptor is implicated in a number of neurological and psychiatric conditions. Drugs acting at dopamine D2 receptors (D2R) are commonly used to alleviate symptoms for Parkinsonâs disease, schizophrenia, and depression. |
Host Cell |
CHO-K1/D2/Gα15 (Cat. No. M00152) |
Concentration |
1 mg/ml in 50 mM HEPES, 5 mM MgCl2, 1 mM CaCl2 and 0.2% BSA, pH7.4 |
Storage |
Store at -80°C |
Application |
Binding assay for D2 receptor |
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TECHNICAL MANUAL: 11298_20091126224802.PDF (PDF)