Human OPRD1 Receptor Membrane Preparation

The delta opioid receptor (also known as OP1, DOP, DOR) is a member of the opioid family of G protein coupled receptors that also includes mu, kappa and NOP receptors. In the CNS, delta opioid receptors are primarily distributed in the olfactory bulb, nucleus accumbens, caudate putamen and neocortex, with low-moderate levels present in the thalamus, hypothalamus and brainstem. Delta opioid receptors play a role in analgesia, motor integration, gastrointestinal motility, olfaction, respiration, cognitive function and mood driven behavior. The enkephalins are generally considered to be the preferred endogenous ligands. The human gene encoding the delta opioid receptor has been localized to chromosome 1 (1p36.1-p34.3).