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*This product is under development*
| Product Name |
Human OPRD1 Receptor Membrane Preparation |
Species |
Human |
| Documents |
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 TECHNICAL MANUAL: 12778_20100518053525.PDF (PDF) |
| Document-EXAMPLE: 12780_20100518204009.JPG (JPG) |
| Document-EXAMPLE: 12781_20100518204037.JPG (JPG) |
| Figures |
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| Reference |
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M Minami, T Nakagawa, et al. (1996) A single residue, Lys108, of the delta-opioid receptor prevents the mu-opioid-selective ligand [D-Ala2,N-MePhe4,Gly-ol5]enkephalin from binding to the delta-opioid receptor. Mol Pharmacol 50,1413-1422
Mark S. Yamamura, Robert Horvath, et al. (1992) Characterization of [3H]naltrindole binding to delta opioid receptors in rat brain. Life Sciences 50(16),119-124
L Fang, R J Knapp, et al. (1994) Characterization of [3H]naltrindole binding to delta opioid receptors in mouse brain and mouse vas deferens: evidence for delta opioid receptor heterogeneity. JPET 268(2),836-846
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Description |
The delta opioid receptor (also known as OP1, DOP, DOR) is a member of the opioid family of G protein coupled receptors that also includes mu, kappa and NOP receptors. In the CNS, delta opioid receptors are primarily distributed in the olfactory bulb, nucleus accumbens, caudate putamen and neocortex, with low-moderate levels present in the thalamus, hypothalamus and brainstem. Delta opioid receptors play a role in analgesia, motor integration, gastrointestinal motility, olfaction, respiration, cognitive function and mood driven behavior. The enkephalins are generally considered to be the preferred endogenous ligands. The human gene encoding the delta opioid receptor has been localized to chromosome 1 (1p36.1-p34.3). |
Host Cell |
CHO-K1/OPRD1/Gα15 |
Concentration |
1 mg/ml in 50 mM HEPES, 0.1 mM EDTA, 10 % glycerol |
Quality Control |
Bmax and Kd are determined using radioligand saturation binding assays (Figure 1).
Expression Level (Bmax): 3.95 pmol/mg membrane protein.
Kd for [3H]Naltrindole: 0.059 nM
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Purity |
Store at -80°C |
Application |
Binding assay for OPRD1 receptor |
 |
1 |
Gene Synthesis: GenScript's custom gene synthesis service starts as LOW as $0.39/bp, with advanced FREE codon optimization tool and seamless cloning technology. |
2 |
PCR Cloning and Subcloning: Start GenScript's flexible PCR cloning and subcloning service RIGHT NOW, getting comprehensive packages delivered in 14 business days. |
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Site-directed Mutagenesis Services: $149/mutation for special mutagenesis bundle. Site-directed Mutagenesis offers point mutations, deletions, and insertions with unparalleled accuracy, unlimited sites, and comprehensive service package. |
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Plasmid DNA Preparation: GenScript plasmid DNA preparation services offer endotoxin FREE and predominantly supercoiling plasmid DNA from 100 ug to 1000 mg start from $50. |
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Document-EXAMPLE: 12780_20100518204009.JPG (JPG)
Document-EXAMPLE: 12781_20100518204037.JPG (JPG)