B16

Murine melanoma; 100 μg/100 μl. Transplantable murine melanomas are well-established models for the study of experimental cancer therapies. Melanomas express different tumor-associated Ags, which are potential targets for novel designs of therapeutic cancer vaccines. Melanoma-associated Ags include tyrosinase and tyrosine-related protein (TRP)-1/2 or the MAGE and BAGE class of Ags. Many immunotherapeutic protocols have been tested using the murine B16 melanoma cell line (and its sublines) that originated in the syngeneic C57BL/6 (H-2b) mouse strain. B16 melanoma cells express some of these melanoma-associated Ags, and their growth can be controlled in vivo by different classes of specific or nonspecific immune effector cells. The B16 cell line contains a large amount of PDGF ß-receptor which makes it a suitable positive control for PDGF ß-receptor.