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M0052
B16
100 ug
$71.50
        
Product Name B16 Figures
Species
Mouse References:

  • Kim KS, et al. Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression. Pigment. Cell Res. Feb 2006; 19(1): 90-98.
  • Gil-Ad I, et al. Phenothiazines induce apoptosis in a B16 mouse melanoma cell line and attenuate in vivo melanoma tumor growth. Oncol. Rep. Jan 2006; 15(1): 107-112.
  • Liu WK, et al. Apoptotic activity of betulinic acid derivatives on murine melanoma B16 cell line. Eur. J. Pharmacol. Sep 2004; 498(1-3): 71-78.

 
Tissue
Other
Description
Murine melanoma; 100 μg/100 μl.
Transplantable murine melanomas are well-established models for the study of experimental cancer therapies. Melanomas express different tumor-associated Ags, which are potential targets for novel designs of therapeutic cancer vaccines. Melanoma-associated Ags include tyrosinase and tyrosine-related protein (TRP)-1/2 or the MAGE and BAGE class of Ags. Many immunotherapeutic protocols have been tested using the murine B16 melanoma cell line (and its sublines) that originated in the syngeneic C57BL/6 (H-2b) mouse strain. B16 melanoma cells express some of these melanoma-associated Ags, and their growth can be controlled in vivo by different classes of specific or nonspecific immune effector cells. The B16 cell line contains a large amount of PDGF ß-receptor which makes it a suitable positive control for PDGF ß-receptor.
Storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Purity
Whole Cell Lysate
Application
Recommended dilutions
Extracts have been quality control tested by Western blot and the Electrophoretic Mobility Shift Assay (EMSA). Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.