Site-directed mutagenesis service

Site-directed Mutagenesis Services

  Site-directed mutagenesis quotation

Site-directed mutagenesis is central to molecular biology, facilitating research in a variety of fields, including studies of gene regulatory elements, DNA-protein interaction, protein structure/function, enzyme active sites, and novel proteins. GenScript's site-directed mutagenesis services, powered by sophisticated gene synthesis technology and high performance GS polymerase, include point mutations, deletions, and insertions. They can be customized to fit any scientific applications.


  • Unparalleled Accuracy: GenScript's high performance GS polymerase ensures accuracy of mutants, avoiding creation of unwanted mutations.
  • Unlimited Sites: Using our sophisticated mutagenesis technology, GenScript can introduce mutations at any site.
  • Mutation on Large Construct: Our technology is optimized to introduce mutations, insertions, and deletions on constructs as large as up to 12 kb (including target gene and its vector).
  • Comprehensive Service Package: We offer comprehensive upstream and downstream services, including template sequencing, expression vector construction, and protein expression and purification
  • Most Competitive Prices

Pricing Information

Bundle Surprise: With advanced technology and upgraded capacity, GenScript is excited to share the benefits with our valued customers by providing our site-directed mutagenesis services at unsurpassed accuracy and price.

Cat.No. Promotion Price per mutation Note
Gene Synthesis and Mutagenesis Bundle Service
  1. Bundle discount is provided to orders with template gene synthesized at GenScript at the same time.
  2. The list price is valid for genes less than 1 kb in length. For genes longer than 1 kb, an additional $100 per kb will be applied. One mutation is defined as any combination of mutations within a 30-base frame.
Standard Mutagenesis

Sample Submission Requirements

Please provide following:

  • The complete sequence of the template including the target gene and its vector
  • Mutation specifications
  • Maps and antibiotic resistance of the template and destination vectors
  • Recommended to send 4 μg of template DNA as the starting material. If the starting material is bacterial culture, please send the culture at sufficient amount.

Delivery Specifications

Our typical turnaround is about 10 business days. Our delivery package includes:

  • 4 μg lyophilized destination vector containing the gene
  • Sequence chromatograms covering your gene (electronic)
  • Construct map for the plasmid (electronic)
  • Quality assurance certificate

Quotations and Ordering

Our customer service representatives are available 24 hours Monday through Friday.
You may contact us anytime for assistance.