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custom peptide synthesis

peptide synthesis

Custom Peptide Synthesis

GenScript provides high-quality peptides with a 95% peptide synthesis success rate, well above the industry standard of 75%. We are committed to Total Quality Management (TQM) to ensure our customers' complete satisfaction. TQM includes MS and HPLC analyses performed after the completion of synthesis, purification, and QC (quality control) steps. These analyses are followed by independent QA (quality assurance) procedures, which double guarantees the highest quality possible for every delivered peptide.

Peptide Synthesis Capacity and Capability

Our custom peptides are synthesized in a 20,000 square foot state-of-the-art facility with peptide synthesizers, HPLCs, and mass spectrometers capable of producing over 6000 peptides per month. Other features of our capacity and capability include:

New! Get peptides faster with the new Express Peptide Synthesis Service

Recent advances in peptide synthesis technology have allowed us to expand our custom peptide synthesis services even further! Now, with GenScript's new Express Peptide Synthesis Service, you can receive high quality peptides from just 5 days! Choose between two service options based on your peptide needs: Rush Peptide Synthesis for quick delivery of crude peptides, and Fast Peptide Synthesis for purified peptides. To get an instant quote, use our secured online quote request system or email us at peptide@genscript.com.

Advantages

  Custom Peptide Synthesis (Cat no. SC1208) Rush Peptide Synthesis (Cat no. SC1845) New! Fast Peptide Synthesis (Cat no. SC1848) New!
Sequence Length Up to 200 AA 5-10 AA 5-20 AA
Purity All purities Crude >70% to >95%
Quantity Mg to kg <20 mg <20 mg
Modifications Comprehensive Amidation (C-terminal) Amidation (C-terminal)
Acetylation (N-terminal) Acetylation (N-terminal)
Starting Turnaround Time 2-3 weeks* 5 days** 9 days**
Free solubility testing Yes Yes Yes
TFA Removal Service Guaranteed or Standard Standard Standard


*Difficult sequences, or peptides with modifications, may require additional synthesis time. In these cases, turnaround time estimates will be provided during the quotation process.

**Includes time for synthesis and shipping from the US. In the event production time exceeds 2 days for Rush Service or 6 days for Fast Service, a refund will be provided. Turnaround times are only applicable to standard peptide sequences within the parameters described. Solubility testing and TFA removal will require additional time.

Peptide Synthesis Technology

GenScript's peptide synthesis technology, FlexPeptide™, increases chemical coupling efficiency and shortens coupling time, which allows us to offer economical peptides. The FlexPeptide™ technology platform combines the following technologies:

  1. Liquid Phase Peptide Synthesis (LPPS) for shorter peptides, or Large-Scale Solid Phase Peptide Synthesis (SPPS) suited for longer, more complex sequences.
  2. Microwave technologies that increase reaction rate and improve peptide yield.
  3. Proprietary ligation technology that allows for the joining of peptides of up to 200 amino acids.


Pricing Information for Peptides

Peptides are competitively priced, starting at $3.20/AA. Modifications, purified peptides, or difficult peptides may incur additional costs. Discounts are available for large-scale peptide synthesis orders.

An additional fee applies to Express Peptide Synthesis Services.

Delivery Specifications

Every step of peptide synthesis is subject to GenScript's stringent quality control. Typical delivery specifications include:

  • Lyophilized peptide of the required sequence, purity, and quantity aliquoted into # of vials specified by customer.
  • QC reports including MS spectra, HPLC chromatograms, and COA documents.
  • Typical turnaround time of 2-3 weeks.

How to download your reports

For all QC, COA and solubility test reports, you can view your documents by visiting your My Account page:

How to download your reports how to donload your reports

TFA Removal Service

TFA is often used in the final cleavage of custom peptides from the solid support after solid phase synthesis. Hence, TFA may be left behind in the final peptide preparation, even after purification. Trace amounts of TFA can cause cytotoxicity in cell culture assays.
More about TFA Removal for Peptides

TFA Removal Service removes the residual TFA and replaces it with your choice of acetate or hydrochloride, both of which are more amenable for cell-based assays. Additional QC reports are provided for peptides for which this service is performed.

*To get a quote for TFA removal service, type "TFA removal requested" in the Comments box when using our online quotation system or include the text in your email request. Final price and turnaround time might be modified by the addition of this test. Get a quote now >>

Solubility Testing

Hydrophobic peptides are often insoluble or have a propensity to aggregate. Using improper conditions for dissolution of these peptides can result in the loss of peptides.
More about Solubility Testing for Peptides

For solubility testing, our peptide synthesis experts perform a systematic dissolution of your peptide in various buffers at varying pH to determine the conditions under which the highest concentration of dissolved peptide can be obtained. A report is constructed detailing the optimal conditions under which your peptide can be solubilized.

*To get a quote for solubility testing, type "Solubility test requested" in the Comments box when using our online quotation system or include the text in your email request. Final price and turnaround time might be modified by the addition of this test. Get a quote now >>

Peptide Content Analysis

Custom peptides are delivered as a gross peptide preparation consisting of a mixture of the target peptide, peptidic impurities, counter ions, and water. A peptide content analysis determines the precise amount of target peptide in the gross peptide preparation. Exact quantification of your peptide can increase experimental accuracy and consistency between different batches of peptide.
More about Peptide Content Analysis

Complimentary ArgonShield™ packaging

Peptides containing Cys, Trp, or Met are susceptible to oxidation, while peptides with multiple charged residues (e.g. Asp, Glu, Lys, Arg or His) are at risk for deliquescence. To protect the activity of your custom peptides, all synthesized peptides are sealed in argon gas-filled vials to prevent oxidization and deliquescence, at no cost to you.

Complimentary aliquoting service

Repeated freeze-thaw cycles can damage your custom peptides. GenScript provides aliquoting services (free for the first 5 vials) for all customer peptide orders.

  • Monoclonal and polyclonal antibody production
  • Identification/synthesis of posttranslational modifications
  • Enzyme specificity and enzymatic mechanisms
  • Biological effects of defined peptides
  • Blocking and competition assays of proteases
  • Non-quantitative enzyme-substrate studies
  • Structure, dynamics, and folding of peptides and proteins via NMR
  • New techniques for separation by chromatography/electrophoresis
  • Antibody-antigen interactions
  • Immunization and quantitative receptor-ligand interactions
  • ELISA standards for measuring titers of antibodies
  • Non-quantitative peptide blocking studies
  • Epitope mapping

Customer Publications

Since 2004, GenScript's Peptide Synthesis Services have helped thousands of scientists publish their research in peer-reviewed journals like Science, Nature, Cell, and PNAS.

Peptides
  • - 1300+ peer-reviewed publications
  • - Thousands of scientists
  • - 150,000+ peptides

Customer Testimonials

"I have been using the peptides from your company since 2004. The high quality standard and competitive price of your company will keep us hooked, hopefully for the years to come."

— Dr. Miguel Morales, Universidad de Barcelona, Spain

"Although I order infrequently I do appreciate the customer service, approx 2-week turnaround time, and rapid delivery to my location. Price is average or slightly lower than average. I have had opportunities to order from other companies at discounts but do not due to concerns about quality. I can depend on GenScript quality."

— Dr. Steven Applequist, Karolinska University Hospital, Sweden

More publications

Quotations and Ordering

Our customer service representatives are available 24 hours, Monday through Friday to assist you.

 
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