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Custom Peptide Synthesis Services


peptide synthesis

Custom Peptide Synthesis

GenScript provides high-quality peptide synthesis service with a 95% peptide synthesis success rate, which is well above the industry standard of 75%. We are committed to Total Quality Management (TQM) to ensure our customers' complete satisfaction. TQM includes MS and HPLC analyses performed after the completion of peptide synthesis, purification, and QC (quality control) steps. These analyses are followed by independent QA (quality assurance) procedures, which double guarantee the highest quality possible for every delivered peptide.

Peptide Synthesis Capacity and Capability

Our custom peptides are synthesized in a 20,000 square foot state-of-the-art facility with peptide synthesizers, HPLCs, and mass spectrometers capable of producing over 6000 peptides per month. Other features of our capacity and capability include:

  • Capacity: 10,000 peptides / month.
  • Flexible quantities: From mg to kg.
  • Flexible purities: Crude, desalt, and from 70% to 98% purity.
  • Synthesis technologies: Combination of solid phase and liquid phase synthesis, and microwave and ligation technologies via
    our Flexpeptide™ technology platform.
  • Modifications: Include phosphorylation, methylation, acetylation, amidation, stable isotope labeling, and many more. View our modifications webpage.
  • Quality control: MS and HPLC analyses after each synthesis step, plus additional QA procedures for every peptide. View our
    TQM quality platform.

Upgraded! Easy Online Quotations - Get a quote in minutes

For an instant peptide synthesis quote use our online quotation system. Unlike online quotation systems other companies, our system will return a quotation price instantly for 95% of the peptide sequences entered. For sequences requiring additional review, a quote price will be e-mailed to you within 24 hours. Special discounts are offered for online quotes. Or you can email us with your peptide quote request at peptide@genscript.com.

peptide synthesis

  • Service Features
  • Additional Services
  • Applications
  • Publications and Testimonials

Advantages

Advantage GenScript Competitors
High synthesis success rate
≥ 95%
≤ 75%
Economical Prices
From $3.2/AA
20% higher
Fast, Secure instant online Quotations
Get a quote online in minutes
Wait day(s) for a quote
Free solubility testing and aliquoting
Yes
No
Guaranteed TFA Removal Service
Yes
No
Advanced synthesis platform
Yes, 5 technologies
No, 1 or 2 technologies

Our Technology

GenScript's FlexPeptide™ technology increases chemical coupling efficiency and shortens coupling time, which allows us to offer economical peptide synthesis services to you. The FlexPeptide™ technology platform combines the following technologies:

  1. Liquid Phase Peptide Synthesis (LPPS) for shorter peptides, or Large-Scale Solid Phase Peptide Synthesis (SPPS) suited for longer, more complex sequences.
  2. Microwave technologies that increase reaction rate and improve peptide yield.
  3. Proprietary ligation technology that allows for the joining of peptides of up to 200 amino acids.

Pricing Information

GenScript's peptide synthesis is competitively priced, starting at $3.2/AA. Customers retain all rights to the sequence data and related intellectual property.

List Price* per amino acid for Peptide of 1-30 amino acids (4 mg)
Purity Crude Desalt >75% >85% >98%
GenScript $3.20 $4.80 $8.80 $10.90 $19.90
Vendor 1 $5.60 $7.20 $14.08 $20.96 $37.12
Vendor 2 $8.32 $10.08 $20.96 $26.08 $55.80
* Additional discounts will be applied for large-scale peptide synthesis orders.

Delivery Specifications

Every step of peptide synthesis is subject to GenScript's stringent quality control. Typical delivery specifications include:

  • Lyophilized peptide of the required sequence, purity, and quantity aliquoted into # of vials specified by customer.
  • QC reports including MS spectra, HPLC chromatograms, and COA documents.
  • Typical turnaround time of 3-4 weeks.

TFA Removal Service

TFA is often used in the final cleavage of custom peptides from the solid support after solid phase synthesis. Hence, TFA may be left behind in the final peptide preparation, even after purification. Trace amounts of TFA can cause cytotoxicity in cell culture assays.
More

TFA Removal Service removes the residual TFA and replaces it with your choice of acetate or hydrochloride, both of which are more amenable for cell-based assays. Additional QC reports are provided for peptides for which this service is performed.

*To get a quote for TFA removal service, type "TFA removal requested" in the Comments box when using our online quotation system or include the text in your email request. Final price and turnaround time might be modified by the addition of this test. Get a quote now >>

Solubility Testing

Hydrophobic peptides are often insoluble or have a propensity to aggregate. Using improper conditions for dissolution of these peptides can result in the loss of peptides.
More

For solubility testing, our peptide synthesis experts perform a systematic dissolution of your peptide in various buffers at varying pH to determine the conditions under which the highest concentration of dissolved peptide can be obtained. A report is constructed detailing the optimal conditions under which your peptide can be solubilized.

*To get a quote for solubility testing, type "Solubility test requested" in the Comments box when using our online quotation system or include the text in your email request. Final price and turnaround time might be modified by the addition of this test. Get a quote now >>

Peptide Content Analysis

Custom peptides are delivered as a gross peptide preparation consisting of a mixture of the target peptide, peptidic impurities, counter ions, and water. A peptide content analysis determines the precise amount of target peptide in the gross peptide preparation. Exact quantification of your peptide can increase experimental accuracy and consistency between different batches of peptide.
More

Complimentary ArgonShield™ packaging

Peptides containing Cys, Trp, or Met are susceptible to oxidation, while peptides with multiple charged residues (e.g. Asp, Glu, Lys, Arg or His) are at risk for deliquescence. To protect the activity of your custom peptides, all synthesized peptides are sealed in argon gas-filled vials to prevent oxidization and deliquescence, at no cost to you.

Complimentary aliquoting service

Repeated freeze-thaw cycles can damage your custom peptides. GenScript provides aliquoting services (free for the first 5 vials) for all customer peptide orders.

Applications

  • Monoclonal and polyclonal antibody production
  • Identification/synthesis of posttranslational modifications
  • Enzyme specificity and enzymatic mechanisms
  • Biological effects of defined peptides
  • Blocking and competition assays of proteases
  • Non-quantitative enzyme-substrate studies
  • Structure, dynamics, and folding of peptides and proteins via NMR
  • New techniques for separation by chromatography/electrophoresis
  • Antibody-antigen interactions
  • Immunization and quantitative receptor-ligand interactions
  • ELISA standards for measuring titers of antibodies
  • Non-quantitative peptide blocking studies
  • Epitope mapping

Customer Publications

Since 2004, GenScript's Peptide Synthesis Services have helped thousands of scientists publish their research in peer-reviewed journals like Science, Nature, Cell, and PNAS.

  • - 1300+ peer-reviewed publications
  • - Thousands of scientists
  • - 150,000+ peptides

Customer Testimonials

"I have been using the peptides from your company since 2004. The high quality standard and competitive price of your company will keep us hooked, hopefully for the years to come."

— Dr. Miguel Morales, Universidad de Barcelona, Spain

"Although I order infrequently I do appreciate the customer service, approx 2-week turnaround time, and rapid delivery to my location. Price is average or slightly lower than average. I have had opportunities to order from other companies at discounts but do not due to concerns about quality. I can depend on GenScript quality."

— Dr. Steven Applequist, Karolinska University Hospital, Sweden

More publications

Quotations and Ordering

  • For quotations, please use our Secure Instant Online Quotation/Order system. However, you may also contact us by email, phone (1-732-885-9188), fax (1-732-210-0262), or via our Secure Messaging System.
  • peptide synthesis Please use our online peptide synthesis ordering system and either a PO (Purchase Order) or credit card to receive GenScript's fastest service. For batch order, please download and complete Peptide Batch Order Form and email it to peptide@genscript.com.
  • We accept POs and major credit cards (credit card order). A 7% New Jersey sales tax will be applied to orders shipped to New Jersey. Your credit card will be billed under "GenScript USA Inc." Click here to download our credit reference form. For international orders, we must apply the full charge at the time the order is placed. In the unlikely event that any given order cannot be filled, our guarantee will take the form of a full refund.

Our customer service representatives are available 24 hours, Monday through Friday to assist you.