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*For Non-Clinical Research Use Only*
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Prepro Thyrotropin-Releasing Hormone (TRH) (160-169)  |
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| Full Name |
Prepro Thyrotropin-Releasing Hormone (TRH) (160-169) |
| Alias |
Ps4 |
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Sequence
(one-letter code) |
SFPWMESDVT |
Sequence
(three-letter code) |
{SER}{PHE}{PRO}{TRP}{MET}{GLU}{SER}{ASP}{VAL}{THR} |
| Description |
The precursor peptide of TRH (prepro-TRH) contains five copes of pro-TRH linked by other peptide sequences. In a heterologous TSH expression assay, we found that prepro-TRH- (160-169) stimulated TSH beta gene promoter activity in a time- and dose-dependent manner; moreover, the effect of prepro-TRH-(160-169) was more rapid and of greater magnitude than that of TRH on TSH beta- directed chloramphenicol acetyltransferase synthesis. In the same cells, we found that prepro-TRH-(160-169) stimulated PRL synthesis and secretion, but the effect was similar in magnitude and duration to that of TRH. The effect of prepro-TRH-(160-169) appears to be additive to that of TRH, suggesting that prepro-TRH-(160-169) may act through a mechanism separate from that of TRH. Thus, prepro-TRH-(160-169) has potent endocritic effects at the level of the genome. |
| Solubility |
Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents. |
| Purity |
> 95% |
| Storage |
Before using, store the peptide in the DRY form at 0 - 5°C. For best and repeatable results, rehydrate the peptide immediately before using. Do not re-freeze any unused portions. |
| Notes |
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Related Products
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1 |
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Standard Peptide Synthesis: GenScript offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. GenScript FlexPeptideTM technology can synthesize peptide as long as 200 amino acids, a world record for such technology.
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3 |
Peptide Modifications: GenScript offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
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Peptide Libraries: GenScript has developed a rapid high-throughput parallel peptide synthesis platform, providing custom libraries of unbound peptides of 5-20 mer at very competitive prices.
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Document-HPLC: 1953_20060721145613.PDF (PDF)