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*For Non-Clinical Research Use Only*
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Orexin B, Canine  |
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| Full Name |
Orexin B, Canine |
Sequence
(one-letter code) |
RPGPPGLQGRLQRLLQASGNHAAGILTM-NH2 |
|
Sequence
(three-letter code) |
{ARG}{PRO}{GLY}{PRO}{PRO}{GLY}{LEU}{GLN}{GLY}{ARG}{LEU}{GLN}{ARG}{LEU}{LEU}{GLN}{ALA}{SER}{GLY}{ASN}{HIS}{ALA}{ALA}{GLY}{ILE}{LEU}{THR}{MET}-NH2 |
| C-Terminal |
NH2 |
| Description |
The hypothalamic peptides hypocretin-1 (orexin A) and hypocretin-2 (Hcrt-2; orexin B) are important in modulating behaviours demanding arousal, including sleep and appetite. The wake-promoting neuropeptides orexins (hypocretins) play a crucial role in controlling neuronal excitability and synaptic transmission in the CNS. Orexin B (Orx-B) depresses the evoked glutamate-mediated synaptic currents in DRN 5-HT neurons. The Orx-B-induced depression is accompanied by an increase in the paired-pulse ratio and the coefficient of variance, suggesting a presynaptic site of action. Orx-B also reduces the frequency but not the amplitude of miniature EPSCs, indicating that depression of glutamatergic transmission is mediated by a decrease in glutamate release. |
| Purity |
> 95% |
| Storage |
Store at -20°C |
| Notes |
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Related Products
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1 |
Peptide Services: GenScript's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
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2 |
Standard Peptide Synthesis: GenScript offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. GenScript FlexPeptideTM technology can synthesize peptide as long as 200 amino acids, a world record for such technology.
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3 |
Peptide Modifications: GenScript offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
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4 |
Peptide Libraries: GenScript has developed a rapid high-throughput parallel peptide synthesis platform, providing custom libraries of unbound peptides of 5-20 mer at very competitive prices.
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Document-MSDS: 4953_20080714013853.PDF (PDF)
