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*For Non-Clinical Research Use Only*
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Kyotorphin  |
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| Full Name |
Kyotorphin |
| Alias |
KyoTyrosine-Arginine |
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Sequence
(one-letter code) |
YR |
Sequence
(three-letter code) |
{TYR}{ARG} |
| Description |
Kyotorphin (Kyo), an endogenous neuropeptide (tyrosine-arginine), plays a role in pain regulation in the brain. This peptide administered centrally produced analgesic effects in mice, possibly through a Met-enkephalin release. The neurochemical basis of mechanisms suggests that Kyo stimulates its specific receptor, followed by Gi and phospholipase C (PLC) activations. Recently, we observed that this PLC mechanism leads to a Ca2+ influx in nerve ending particles or synaptosomes. In this report, we propose the hypothesis that inositol 1,4,5-trisphosphate (InsP3) elicits Ca2+ transport through plasmalemmal InsP3 receptor but not through intrasynaptosomal Ca2+ stores. Because neurochemically dissociated synaptosomes may not be exclusively pure but may contain various other subfractions, however, this hypothesis is required to be further confirmed through more physiological approaches. |
| Solubility |
Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents. |
| Purity |
> 95% |
| Storage |
Storage at -20°C. Keep tightly closed. |
| Notes |
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1 |
Peptide Services: GenScript's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
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2 |
Standard Peptide Synthesis: GenScript offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. GenScript FlexPeptideTM technology can synthesize peptide as long as 200 amino acids, a world record for such technology.
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3 |
Peptide Modifications: GenScript offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
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4 |
Peptide Libraries: GenScript has developed a rapid high-throughput parallel peptide synthesis platform, providing custom libraries of unbound peptides of 5-20 mer at very competitive prices.
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Document-HPLC: 2001_20060721145615.PDF (PDF)