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Neurokinin A (4-10)

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A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) was performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK2 receptor in human colon circular muscle. Two series of NKA(4-10) analogues were produced with either L-alanine or the D-enantiomer substituted. Their activities were determined in vitro by means of radioligand binding and isolated smooth muscle pharmacology.
RP10516
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Description

A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) was performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK2 receptor in human colon circular muscle. Two series of NKA(4-10) analogues were produced with either L-alanine or the D-enantiomer substituted. Their activities were determined in vitro by means of radioligand binding and isolated smooth muscle pharmacology.

Synonyms

NKA (4-10)

Cas No 97559-35-8
Sequence
{ASP}{SER}{PHE}{VAL}{GLY}{LEU}{MET}-NH2
Sequence Shortening DSFVGLM-NH2
Molecular Formula C34H54N8O10S
C Terminal NH2
Molecular Weight 766.9
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Purity > 95%
Storage Store at -20°C.
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