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β-Melanocyte Stimulating Hormone (MSH), human

Alias beta melanocyte stimulating hormoneβ-MSH, human
Description Alpha-MSH (melanocyte stimulating hormone) has generally been assumed to be the endogenous ligand acting at the melanocortin-4 receptor (MC4-R), activation of which in the hypothalamus leads to reduced feeding. However, beta-MSH is also capable of activating MC4-R and inhibiting feeding. The researchers found that obese children are more likely to carry a rare variant of so-called beta-melanocyte-stimulating hormone (beta-MSH) than children of normal weight.
Formula C118H174N34O35S1
Molecular Weight 2661.000
Sequence (one-letter code) AEKKDEGPYRMEHFRWGSPPKD
Sequence (three-letter code) {ALA}{GLU}{LYS}{LYS}{ASP}{GLU}{GLY}{PRO}{TYR}{ARG}{MET}{GLU}{HIS}{PHE}{ARG}{TRP}{GLY}{SER}{PRO}{PRO}{LYS}{ASP}

Storage Store the peptide at -20°C. Keep container tightly closed. Store in a cool dry place.
Purity > 95%

Cat. No.
Product Name
RP10644-5 α-Melanocyte-Stimulating Hormone (MSH), amide
5 mg
RP10644-1 α-Melanocyte-Stimulating Hormone (MSH), amide
1 mg
RP10650 γ-1-Melanocyte Stimulating Hormone (MSH), amide
1 mg
RP10658-1 [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone (MSH), amide
1 mg
RP17323 Melanotan (MT)-II
5 mg
Spencer JD, et al. A novel mechanism in control of human pigmentation by {beta}-melanocyte-stimulating hormone and 7-tetrahydrobiopterin. J.Endocrinol. Nov 2005; 187(2): 293-302.

You can visit "Citations Database" for more citations. Leder EH, Silverstein JT. The pro-opiomelanocortin genes in rainbow trout (Oncorhynchus mykiss): duplications, splice variants, and differential expression. J.Endocrinol. Feb 2006; 188(2): 355-363.

You can visit "Citations Database" for more citations. Hinney A, et al. Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from Germany. J.Clin.Endocrinol.Metab. May 2006; 91(5): 1761-1769.

You can visit "Citations Database" for more citations.

For more documents, please visit "Technical Support".
Cat. No. RP10648
1 mg $90.00