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*For Non-Clinical Research Use Only*
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Interleukin (IL)-6 Receptor  |
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| Full Name |
Interleukin (IL)-6 Receptor |
| Alias |
IL-6 RIL6R peptide |
|
Sequence
(one-letter code) |
TSLPVQDSSSVP |
Sequence
(three-letter code) |
{THR}{SER}{LEU}{PRO}{VAL}{GLN}{ASP}{SER}{SER}{SER}{VAL}{PRO} |
| Description |
A soluble form of the Interleukin-6 receptor (IL-6R) was initially identified in the urine of healthy adult humans, in culture supernatants from HTLV-I positive T cell lines and in the serum of HIV-seropositive blood donors. These soluble receptors (Interleukin-6 receptor) may develop as a result of alternate splicing of the mRNA or as a result of proteolytic cleavage and release of the membrane-bound form of the receptor. Recombinant, Human IL-6 Soluble Receptor was produced by cloning the cDNA of the IL-6R and introducing a stop codon into the cDNA sequence immediately preceding the transmembrane domain. This was followed by infection of Sf 21 insect cells with recombinant baculovirus encoding the sequence for the truncated receptor. The IL-6 soluble receptor is 339 amino acid residues in length. IL-6 soluble receptor may serve to transport IL-6, protecting IL-6 from proteolysis. Alternatively, the IL-6 soluble receptor may act as an inhibitory agent to localize the activity of IL-6 or to bind IL-6 that is not bound to cell surface receptors. The bioactivity of IL-6 increases after binding to the soluble IL-6 receptor. |
| Purity |
> 95% |
| Storage |
Stored at -20°C. |
| Notes |
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Related Products
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1 |
Peptide Services: GenScript's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
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2 |
Standard Peptide Synthesis: GenScript offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. GenScript FlexPeptideTM technology can synthesize peptide as long as 200 amino acids, a world record for such technology.
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3 |
Peptide Modifications: GenScript offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
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4 |
Peptide Libraries: GenScript has developed a rapid high-throughput parallel peptide synthesis platform, providing custom libraries of unbound peptides of 5-20 mer at very competitive prices.
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Document-HPLC: 2149_20060721145623.PDF (PDF)
