Vanilloid Receptor Subtype 1 (VR1)
*This product has been discontinued!*
VR1 is widely distributed in the skin, e.g. in nociception and neurogenic inflammation. VR1 is a capsaicin-receptor homologue with a high threshold for noxious heat. As revealed by ELISA, capsaicin induced IL-6 expression in PF-10 cells, and the VR1 antagonist capsazepine dose-dependently inhibited capsaicin-induced IL-6 production, indicating that capsaicin-induced IL-6 expression is related to VR1 activation.
| RP11755 | |
|
|
|
|
|
|
| Ask us a question | |
