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Hot Products
*For Non-Clinical Research Use Only*
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P75-TNFR  |
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| Full Name |
P75-TNFR |
| Alias |
TNFR-II |
|
Sequence
(one-letter code) |
SMAPGAVHLPQP |
Sequence
(three-letter code) |
{SER}{MET}{ALA}{PRO}{GLY}{ALA}{VAL}{HIS}{LEU}{PRO}{GLN}{PRO} |
| Description |
The P75 TNFR (TNFR-II) membrane receptor is expressed on most mammalian cells. The actions of TNF-α are mediated via a 55,000/60,000 Da receptor (TNFR-I) and a 75,000/80,000 Da receptor (TNFR-II). The cleavage site for TNFR-II is Val192âHis193, which is 14 amino acids from the cysteine-rich extracellular domain, compared with six amino acids for TNFR-I. The P75-TNFR directly mediates distinct cellular responses such as proliferation of T and B cells, activation of NF-β, and induction of cytotoxicity. A recent study has described an assay using cells expressing TNFR-II at the cell surface to partially characterize a soluble metallosecretase that is itself secreted into the media upon phorbol ester stimulation of the cells. |
| Purity |
> 95% |
| Storage |
Store at -20°C. Keep tightly closed. Store in a cool dry place. |
| Notes |
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1 |
Peptide Services: GenScript's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
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2 |
Standard Peptide Synthesis: GenScript offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. GenScript FlexPeptideTM technology can synthesize peptide as long as 200 amino acids, a world record for such technology.
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3 |
Peptide Modifications: GenScript offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
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4 |
Peptide Libraries: GenScript has developed a rapid high-throughput parallel peptide synthesis platform, providing custom libraries of unbound peptides of 5-20 mer at very competitive prices.
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Document-MSDS: 5025_20080715212049.PDF (PDF)
