TAT

*This product has been discontinued!*

TaT is a transcriptional transactivator protein that binds to a regulatory element in the HIV-1 long terminal repeat. By recruiting P-TEFb to TAR, TaT promotes transcription of viral mRNA. This arginine-rich TAT peptide penetrates plasma membrane directly, but not through endocytosis. TaT has similar immunosuppressive effects as transforming growth factor-beta (TGF beta) and both inhibit lymphocyte proliferation.

Cat. No.	RP12784
Size	Buy in bulk

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Overview Properties

Overview

Description	TaT is a transcriptional transactivator protein that binds to a regulatory element in the HIV-1 long terminal repeat. By recruiting P-TEFb to TAR, TaT promotes transcription of viral mRNA. This arginine-rich TAT peptide penetrates plasma membrane directly, but not through endocytosis. TaT has similar immunosuppressive effects as transforming growth factor-beta (TGF beta) and both inhibit lymphocyte proliferation.
Sequence	{TYR}{GLY}{ARG}{LYS}{LYS}{ARG}{ARG}{GLN}{ARG}{ARG}{ARG}-NH₂
Sequence Shortening	YGRKKRRQRRR-NH₂
Molecular Formula	C₆₄H₁₁₉N₃₃O₁₃
C Terminal	NH₂
Molecular Weight	1558.85

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Properties

Purity	> 95%
Form	Lyophilized
Storage	Store at -20°C. Keep tightly closed. Store in a cool dry place.

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