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*For Non-Clinical Research Use Only*
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IRL-1620  |
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| Full Name |
IRL-1620 |
| Alias |
IRL-1620; IRL1620 |
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Sequence
(one-letter code) |
Suc-[Glu9Ala11,15]-Endothelin-1(8-21)Suc-DEEAVYFAHLDIIW |
Sequence
(three-letter code) |
Suc-[Glu9Ala11,15]-Endothelin-1(8-21)Suc-Asp-Glu-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp |
| Description |
IRL-1620 significantly enhanced delivery and effectiveness of paclitaxel in an animal model of breast cancer. IRL-1620 together with IRL-1038 (Prod. No. ALX-155-007) is an indispensable pharmacological tool to assess the participation of the ETB receptor in some pathophysiological phenomena, by selectively stimulating ETB receptor-mediated responses in various pathophysiological models established in vitro and in vivo. |
| Solubility |
Insoluble in water. Dissolve the content with > pH 8.5 buffer. |
| Purity |
> 95% |
| Storage |
Store at -20°C. |
| Notes |
This peptide is most potent and specific ligand for the ETB receptor (KiETA/KiETB=120 000) as judged by the Ki values for ETA (1.9 µM) and ETB (16 pM) receptors. IRL1620 (10-9-10-7 µM) induced contraction of the guinea pig tracheal with a comparable potency to those of ET-1 or ET-3. |
Related Products
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Standard Peptide Synthesis: GenScript offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. GenScript FlexPeptideTM technology can synthesize peptide as long as 200 amino acids, a world record for such technology.
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Peptide Modifications: GenScript offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
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Peptide Libraries: GenScript has developed a rapid high-throughput parallel peptide synthesis platform, providing custom libraries of unbound peptides of 5-20 mer at very competitive prices.
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Document-MSDS: 5651_20080909223140.PDF (PDF)