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Hot Products
*For Non-Clinical Research Use Only*
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Enfuvirtide (T-20)  |
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| Full Name |
Enfuvirtide (T-20) |
| Alias |
ENF |
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Sequence
(one-letter code) |
Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2 |
Sequence
(three-letter code) |
Ac-{TYR}{THR}{SER}{LEU}{ILE}{HIS}{SER}{LEU}{ILE}{GLU}{GLU}{SER}{GLN}{ASN}{GLN}{GLN}{GLU}{LYS}{ASN}{GLU}{GLN}{GLU}{LEU}{LEU}{GLU}{LEU}{ASP}{LYS}{TRP}{ALA}{SER}{LEU}{TRP}{ASN}{TRP}{PHE}-NH2 |
| C-Terminal |
NH2 |
| Description |
36 residue synthetic peptide that inhibits HIV-1 fusion with CD4 cells. N-terminal acetylated, C-terminal amide. Enfuvirtide is the first in this class to reach market approval. Fusion inhibitors block the last step in the three-step viral entry process consisting of attachment, co-receptor binding and fusion, thereby preventing viral capsid entry into the host cell. Enfuvirtide has a unique mechanism of action and high viral target specificity, and in clinical trials has been shown to exhibit both high efficacy and low toxicity. Enfuvirtide is a peptide mimetic of an essential region within viral envelope glycoprotein gp41 that functions by blocking gp41 structural rearrangements at a transitional pre-fusion conformation. |
| Purity |
> 95% |
| Storage |
Store at -20°C. Keep tightly closed. Store in a cool dry place. |
| N-Terminal |
Ac |
| Notes |
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1 |
Peptide Services: GenScript's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
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2 |
Standard Peptide Synthesis: GenScript offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. GenScript FlexPeptideTM technology can synthesize peptide as long as 200 amino acids, a world record for such technology.
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3 |
Peptide Modifications: GenScript offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
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4 |
Peptide Libraries: GenScript has developed a rapid high-throughput parallel peptide synthesis platform, providing custom libraries of unbound peptides of 5-20 mer at very competitive prices.
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Document-MSDS: 5725_20080915212928.PDF (PDF)
