|
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Hot Products
*For Non-Clinical Research Use Only*
|
β-Amyloid (22-35)  |
|
|
| Full Name |
β-Amyloid (22-35) |
| Alias |
Beta-Amyloid (22-35) |
|
Sequence
(one-letter code) |
EDVGSNKGAIIGLM |
Sequence
(three-letter code) |
{Glu}{Asp}{Val}{Gly}{Ser}{Asn}{Lys}{Gly}{Ala}{Ile}{Ile}{Gly}{Leu}{Met} |
| Description |
Beta amyloid (22-35) is a synthetic truncated fragment of beta-amyloid peptide. It has been demonstrated that beta amyloid (22-35) possesses a cytotoxic effect on cultured rat hippocampus neurons in serum-free medium. Aggregates and typical amyloid fibrils resembling those of the beta amyloid protein (AP) are formed in neutral buffer solution from beta amyloid (22-35). These fibrils show characteristic staining with Congo red and thioflavin-S. The neurotoxicity of beta amyloid (22-35) can be suppressed by addition of calf serum, dibutyryl cAMP, or insulin to the culture medium. However, the addition of NGF or substance P will not suppress the neurotoxicity. Beta amyloid (22-35) does not act on glial cells. These results suggest that AP can induce neurotoxicity in hippocampal cells in vitro and may result in a disorder involving intracellular signal transduction. |
| Solubility |
Soluble in water. |
| Purity |
> 95% |
| Storage |
Store at -20°C. Keep tightly closed. Store in a cool dry place. |
| Notes |
|
 |
1 |
Peptide Services: GenScript's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
|
2 |
Standard Peptide Synthesis: GenScript offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. GenScript FlexPeptideTM technology can synthesize peptide as long as 200 amino acids, a world record for such technology.
|
3 |
Peptide Modifications: GenScript offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
|
4 |
Peptide Libraries: GenScript has developed a rapid high-throughput parallel peptide synthesis platform, providing custom libraries of unbound peptides of 5-20 mer at very competitive prices.
|
|
Document-MSDS: 8245_20081117004630.PDF (PDF)