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Hot Products
*For Non-Clinical Research Use Only*
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Hemopressin, Human  |
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| Full Name |
Hemopressin, Human |
Sequence
(one-letter code) |
PVNFKLLSH |
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Sequence
(three-letter code) |
{Pro}{Val}{Asn}{Phe}{Lys}{Leu}{Leu}{Ser}{His} |
| Description |
As a novel nonapeptide, hemopressin is vasoactive. It is derived from hemoglobinâs alpha-chain. Acting as endogenous peptide ligand for CB1 receptors, the hemoglobin fragment hemopressin dilates the rat systemic vascular bed by releasing nitric oxide. Current studies are focused on the effects of intravenous (i.v.) administration of rat hemopressin (rHP), 30-1000 microg/kg, on systemic arterial pressure (SAP), cardiac output (CO), and systemic vascular resistance (SVR) in the anesthetized rat. Bolus i.v. injections of rHP result in dose-dependent mild decreases in SAP. With an unaltered level of CO, the decreases in SAP show a relationship with SVR reduction. Unaffected by tachyphylaxis, the systemic vasodilator response to rHP is abolished by L-nitro-arginine methyl ester (L-NAME) but is not altered by meclofenamate. In addition, rHP does not have direct contractile or relaxant activity on either isolated rat aortic rings (AA) or pulmonary arterial rings (PA). Current data suggest that the mechanism of rHP dilation of the rat systemic vascular bed is through the endogenous release of nitric oxide (NO) independent of the formation of cyclooxygenase products such as prostacyclin. It is possible for rHP to act as an endogenous vasodilator substance regulating the local blood flow during clinical states of altered red cell turnover, microvascular disease and hemolysis. |
| Purity |
> 95% |
| Storage |
Store at -20°C. Keep tightly closed. Store in a cool dry place. |
| Notes |
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1 |
Peptide Services: GenScript's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
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2 |
Standard Peptide Synthesis: GenScript offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. GenScript FlexPeptideTM technology can synthesize peptide as long as 200 amino acids, a world record for such technology.
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Peptide Modifications: GenScript offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
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Peptide Libraries: GenScript has developed a rapid high-throughput parallel peptide synthesis platform, providing custom libraries of unbound peptides of 5-20 mer at very competitive prices.
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Document-MSDS: 8920_20081208220707.PDF (PDF)