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Mouse Anti-HIV-1 gp41 Monoclonal Antibody  |
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Note: | This product has been discontinued!
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| Full Name | | | Alias | Anti HIV-I gp41; Anti HIV-1 gp41; Anti HIV1 gp41; Anti HIVI gp41 |
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| Abbreviated Name-2 | mAHIV-I gp41 |
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| Description | Human immunodeficiency virus (HIV) is a retrovirus that can lead to a condition in which the immune systembegins to fail, leading to opportunistic infections. HIV primarily infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. HIV infection leads to low levels of CD4+ T cells through three main mechanisms: firstly, direct viral killing of infected cells; secondly, increased rates of apoptosisin infected cells; and thirdly, killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunityis lost, and the body becomes progressively more susceptible to opportunistic infections. HIV was classified as a member of the genus lentivirus, part of the family of Retroviridae. Lentiviruses have many common morphologies and biological properties. Many species are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with a long incubation period. Lentiviruses are transmitted as single-stranded, positive-sense, enveloped RNA viruses. Upon entry of the target cell, the viral RNA genomeis converted to double-stranded DNA by a virally encoded reverse transcriptase that is present in the virus particle. This viral DNA is then integrated into the cellular DNA by a virally encoded integrase so that the genome can be transcribed. Once the virus has infected the cell, two pathways are possible: either the virus becomes latent and the infected cell continues to function, or the virus becomes active and replicates, and a large number of virus particles are liberated that can then infect other cells. |
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| Ig Subclass | Mouse IgG1 |
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| Storage | Lyophilized: store at 4°C. After reconstitution, if not used within a month, aliquot and store at -20°C. |
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| Stability | Two years lyophilized. Six months in solution at 4°C. |
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| Concentration | 1 mg/ml in PBS (after reconstitution) |
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| Clone | A00020.01 |
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| Immunogen | rec. gp41 |
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| Purification Method | Ion exchange column |
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| Reconstitution | Reconstitute with H2O. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. |
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| Titer | By direct ELISA (against recombinant gp41), 1:10,000 dilution will yield 0.27 OD using alkaline phosphatase conjugated rabbit anti-mouse Ig (Jackson Laboratories). |
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| Applications | ELISA |
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| Conjugation | Unconjugated |
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| Host Species | Mouse |
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| Note | Briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container's cap because small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage. |
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| * For Non-Clinical Research Use Only * If you cannot find your antibodies on our list, try our Express AntibodyTM Service, and receive high-quality, titer-guaranteed antibodies in only 5-8 weeks. Our customer service is available 24 hours, Monday through Friday. You may contact us any time for assistance. |
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