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| Full Name | |
| Alias | CD8 |
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| Abbreviated Name-2 | mAhCD8 |
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| Description | CD8 is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 acts as a co-receptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional CD8 is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.
CD8 identifies cytotoxic/suppressor t-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of t-cell mediated killing. CD8 alpha chains binds to class-I MHC molecules alpha-3 domains. |
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| Ig Subclass | Mouse IgG2a |
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| Storage | Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C. |
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| Stability | Two years lyophilized, one month in solution at 4°C |
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| Concentration | 1 mg/ml in PBS (after reconstitution) |
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| Clone | A00027.01 |
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| Immunogen | Purified human PBL CD8+ T cells |
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| Purification Method | Ion exchange column |
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| Reconstitution | Reconstitute with H2O. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. |
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| Applications | Staining antibody, weakly cytotoxic. For staining, use 10 µl/106 cells. Titer for cytotoxicity should be determined by the investigator. |
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| Conjugation | Unconjugated |
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| Host Species | Mouse |
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| Antigen Species | Human |
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| Note | Briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container's cap because small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage. |
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